Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

Wang, Tianming; Cao, Zheng; Shen, Zhangfei; Yang, Jingwen; Chen, Xu; Yang, Zhen; Xu, Ke; Xiang, Xiaowei; Yu, Qiuhan; Song, Yimin; Wang, Weiwei; Yan, Tian; Sun, Lina; Zhang, Libin; Guo, Su; Zhou, Naiming

doi:10.7554/elife.53370

Cited by 14 publications

(15 citation statements)

References 67 publications

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“…A total of 26 KiSS1 precursor sequences were identified from S. mekongi adult worms using the transcriptome mining approach. In the sea cucumber Apostichopus japonicas , KiSS1 neuropeptides play roles in triggering rapid intracellular mobilization of Ca 2 + and are closely related to seasonal reproduction and metabolism [ 37 ]. KiSS1 has been described in teleosts such as the sea bass.…”

Section: Discussionmentioning

confidence: 99%

Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera

et al. 2021

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Schistosoma mekongi is found in the lower Mekong river region and causes schistosomiasis. Low sensitivity of diagnosis and development of drug resistance are problems to eliminate this disease. To develop novel therapies and diagnostics for S. mekongi, the basic molecular biology of this pathogen needs to be explored. Bioactive peptides have been reported in several worms and play important roles in biological functions. Limited information is available on the S. mekongi peptidome. Therefore, this study aimed to identify S. mekongi peptides using in silico transcriptome mining and mass spectrometry approaches. Schistosoma peptide components were identified in adult worms, eggs, and infected mouse sera. Thirteen neuropeptide families were identified using in silico predictions from in-house transcriptomic databases of adult S. mekongi worms. Using mass spectrometry approaches, 118 peptides (from 54 precursor proteins) and 194 peptides (from 86 precursor proteins) were identified from adult worms and eggs, respectively. Importantly, eight unique peptides of the S. mekongi ubiquitin thioesterase, trabid, were identified in infected mouse sera 14, 28, and 56 days after infection. This protein may be a potential target for diagnosis of schistosomiasis. The S. mekongi peptide profiles determined in this study could be used for further drug and diagnostic development.

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Section: Discussionmentioning

confidence: 99%

Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera

et al. 2021

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“…J Physiol 600.5 atrophy of the intestinal tract and weight loss in male and female sea cucumbers (Wang et al 2020).…”

Section: Kisspeptin and Body Weightmentioning

confidence: 99%

“…Chicks respond differently to appetite-regulating peptides from mammals (e.g. ghrelin is anorexigenic in chicks (Saito et al 2002), but is potently orexigenic in rodents and humans (Nakazato et al 2001;Wren et al 2001)). These different appetite circuits may explain the contrasting effects observed when kisspeptin is administered to rodents and chicks.…”

Section: Kisspeptin and Appetite/food Intake Regulationmentioning

confidence: 99%

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Emerging roles for kisspeptin in metabolism

Izzi‐Engbeaya

Dhillo

2021

The Journal of Physiology

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Kisspeptin, a neuropeptide hormone, has been firmly established as a key regulator of the hypothalamic-pituitary-gonadal axis and mammalian reproductive behaviour. In recent years, a growing body of evidence has emerged suggesting a role for kisspeptin in regulating metabolic processes. This data suggest that kisspeptin exerts its metabolic effects indirectly via Chioma Izzi-Engbeaya (MBBS PhD MRCP) is an Imperial-BRC Research Fellow at Imperial College London and a Consultant Endocrinologist at Imperial College Healthcare NHS Trust. Her research focuses on the hormonal control of metabolism and reproduction. Her work demonstrated for the first time in humans that kisspeptin enhances insulin secretion. Additionally, she is pioneering the use of novel techniques such as thermal imaging to study brown adipose tissue activation and the use of aptamer-based hormone measurement. Waljit Dhillo (MBBS PhD FRCP) is a Professor of Endocrinology and Metabolism at Imperial College London and a Consultant Endocrinologist at Imperial College Healthcare NHS Trust. His research has focused on understanding the neuroendocrine mechanisms which are important in the regulation of food intake. Furthermore, his recent pioneering translational research has identified kisspeptin as a novel therapeutic target for patients with infertility and NK3 receptor antagonists as a new treatment for post-menopausal flushing.

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“…However, a precursor of two kisspeptin-like peptides has been identified in the starfish Asterias rubens [31], and orthologs of this precursor have been identified in other echinoderms, including brittle stars, sea urchins, and sea cucumbers [32]. Furthermore, kisspeptin-like peptides act as ligands for two kisspeptin-type receptors in the sea cucumber Apostichopus japonicus [33].…”

Section: Introductionmentioning

confidence: 99%

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

et al. 2022

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Background Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus. Phylogenetic analysis of kisspeptin-type receptors indicates that this neuropeptide signaling system originated in a common ancestor of the Bilateria, but little is known about kisspeptin signaling in invertebrates. Results Contrasting with the occurrence of a single kisspeptin receptor in mammalian species, here, we report the discovery of an expanded family of eleven kisspeptin-type receptors in a deuterostome invertebrate — the starfish Asterias rubens (phylum Echinodermata). Furthermore, neuropeptides derived from four precursor proteins were identified as ligands for six of these receptors. One or more kisspeptin-like neuropeptides derived from two precursor proteins (ArKPP1, ArKPP2) act as ligands for four A. rubens kisspeptin-type receptors (ArKPR1,3,8,9). Furthermore, a family of neuropeptides that act as muscle relaxants in echinoderms (SALMFamides) are ligands for two A. rubens kisspeptin-type receptors (ArKPR6,7). The SALMFamide neuropeptide S1 (or ArS1.4) and a ‘cocktail’ of the seven neuropeptides derived from the S1 precursor protein (ArS1.1-ArS1.7) act as ligands for ArKPR7. The SALMFamide neuropeptide S2 (or ArS2.3) and a ‘cocktail’ of the eight neuropeptides derived from the S2 precursor protein (ArS2.1-ArS2.8) act as ligands for ArKPR6. Conclusions Our findings reveal a remarkable diversity of neuropeptides that act as ligands for kisspeptin-type receptors in starfish and provide important new insights into the evolution of kisspeptin signaling. Furthermore, the discovery of the hitherto unknown relationship of kisspeptins with SALMFamides, neuropeptides that were discovered in starfish prior to the identification of kisspeptins in mammals, presents a radical change in perspective for research on kisspeptin signaling.

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Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

Cited by 14 publications

References 67 publications

Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera

Identification of Low Molecular Weight Proteins and Peptides from Schistosoma mekongi Worm, Egg and Infected Mouse Sera

Emerging roles for kisspeptin in metabolism

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

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