Existe alguma associação entre gravidade de degeneração discal e dor lombar?

Foizer, Guilherme Augusto; Paiva, Vagner Cleyton de; Nascimento, Rodrigo Domingues do; Gorios, Carlos; Júnior, Alberto Cliquet; Miranda, João Batista de

doi:10.1055/s-0041-1735831

Cited by 6 publications

(2 citation statements)

References 30 publications

(94 reference statements)

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“…Low back pain (LBP) is the most prevalent musculoskeletal disease, affecting between 20% and 50% of the adult population, and it is the leading diagnosis of years lived with disability (YLD) in the general population [ 3 , 4 , 5 ]. Degenerative processes in the spine, mainly in the intervertebral discs [ 6 ], and of the facet joint (i.e., facet arthrosis) are frequently found in LBP [ 7 , 8 , 9 ]. However, therapies that restore degenerated structures are not available in current clinical practice [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

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Background: Low back pain (LBP) has a high economic burden and is strongly related to the degenerative process of the spine, especially in the intervertebral disc and of the facet joints. Numerous treatment modalities have been proposed for the management of LBP, and the use of platelet-rich plasma (PRP) has emerged as an innovative therapeutic option for degenerative disease of the spine. The present study aims to evaluate the efficacy of PRP injections in managing low back pain. Methods: We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, a registered at PROSPERO Systematic Reviews Platform, under number CRD42021268491. The PubMed, Web of Science, and Scopus databases were searched to identify relevant articles, along with hand searching to identify gray literature articles, with no language restrictions. Randomized clinical trials (RCTs), nonrandomized trials (NRTs), and case series (CSs) with more than 10 patients were considered eligible. The quality assessment and the risk of bias of the randomized clinical trials were evaluated using the RoB II tool. An evaluation of the description of the preparation methods was performed using an adapted version of the MIBO checklist. Results: An electronic database search resulted in 2324 articles, and after the exclusion of noneligible articles, 13 RCTs and 27 NRTs or CSs were analyzed. Of the 13 RCTs, 11 found favorable results in comparison to the control group in pain and disability, one showed no superiority to the control group, and one was discontinued because of the lack of therapeutic effect at eight-week evaluation. Description of the PRP preparation techniques were found in almost all papers. The overall risk of bias was considered high in 2 papers and low in 11. An adapted MIBO checklist showed a 72.7% compliance rate in the selected areas. Conclusions: In this systematic review, we analyzed articles from English, Spanish and Russian language, from large databases and grey literature. PRP was in general an effective and safe treatment for degenerative LPB. Positive results were found in almost studies, a small number of adverse events were related, the risk of bias of the RCTs was low. Based on the evaluation of the included studies, we graded as level II the quality of the evidence supporting the use of PRP in LBP. Large-scale, multicenter RCTs are still needed to confirm these findings.

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Section: Introductionmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Machado,

Soares,

Vianna de Abreu

et al. 2023

Biomedicines

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“…Degenerative processes of the spine not only include OA of the facet joints but also alterations of the intervertebral discs [10][11][12]. In the early phases of disc degeneration a balance shift of anabolic and catabolic activity of extracellular matrix molecules and chondrocytes occurs, which also involves the presence of pro-inflammatory cytokines, including IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-17, interferon-γ and TNFα [13,14].…”

Section: Introductionmentioning

confidence: 99%

Histopathology of the Intervertebral Disc of Nothobranchius furzeri, a Fish Model of Accelerated Aging

Butylina,

Wahl-Figlash,

Kothmayer

et al. 2023

Biology

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Introduction: Osteoarthritis is a classical age-related disease, which affects millions of patients worldwide. To further understand the pathophysiology and to develop therapeutic strategies for this disease, animal models play a significant role. Nothobranchius furzeri is an established model for accelerated aging that spontaneously develops spinal deformities. Although the bone properties of N. furzeri are well described, characteristics of the intervertebral discs are still unknown. The aim of this study was to investigate the characteristics of the intervertebral discs of healthy and deformed N. furzeri. Material and Methods: Intervertebral properties of healthy and deformed N. furzeri were investigated in 8-, 12-, 18- and 21.5-week-old male fish of the GRZ strain. For histological evaluations the fish were decalcified, paraffin-embedded and stained with (1) hematoxylin and eosin, (2) toluidine blue and (3) alcian blue/picrosirius red. Results: 8-week-old and deformed N. furzeri showed spongy-like tissue containing vacuolated notochord cells and a beginning formation of fibrous tissue in the central area. Older healthy fish showed fibrous tissue in the central region and a spongy-like tissue in the peripheral region. Conclusion: Our study revealed age- and disease-related alterations of the vertebral discs in N. furzeri. Further studies should investigate the utility of N. furzeri as a model for degenerative spine diseases.

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Loss of lumbar disc height with age and its impact on pain and sensitivity associated behaviors in mice

et al. 2023

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Purpose Aging is a risk factor for several debilitating conditions including those related to chronic back pain and intervertebral disc degeneration, both of which have no cure. Mouse models are useful tools for studying disc degeneration and chronic back pain in a tightly controlled and clinically relevant aging environment. Moreover, mice offer the advantage of carrying out longitudinal studies to understand the etiology and progression of disc pathology induced by genetic or surgical strategies. Previously, age-related behavioral trends of discomfort and enhanced nociception in mice were reported; however, whether these measures are mediated by structural and pathological changes in the disc is unknown. Methods The goal of the present observational study was to identify behavioral correlates of age-related degenerative changes in the disc. Towards this, we collected radiographs from 150 mice (77 females) between three and 23 months of age and measured the disc height index for each level of lumbar disc. Behavioral measures were collected on several of these mice which included rearing and distance travelled in an open field test; time spent in rearing, reaching, immobile, and self-suspended in the tail suspension test; bilateral hind paw licking in response to cold allodynia using acetone; and unilateral hind paw licking in response to heat hyperalgesia using capsaicin. Results Results show that the lower lumbar discs lose height with age and these changes are independent of body composition measures including body weight, bone mineral density, fat mass, lean weight mass, percent fat mass, and percent lean mass. Disc height positively correlates with rearing and mobility in the open field test, immobility in the tail suspension test, and thermal hyperalgesia. Disc height negatively correlates with cold allodynia and rearing in the tail suspension test. Furthermore, mediation analysis shows that the lumbosacral disc significantly mediates the effect of age on rearing in the open field test, but not cold allodynia, suggesting this behavior is a useful measure of age-related axial discomfort due to disc degeneration. Conclusion In summary, the findings from the current study show that disc height are associated with measures of axial discomfort and nociception in mice.

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Existe alguma associação entre gravidade de degeneração discal e dor lombar?

Cited by 6 publications

References 30 publications

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Systematic Review of Platelet-Rich Plasma for Low Back Pain

Histopathology of the Intervertebral Disc of Nothobranchius furzeri, a Fish Model of Accelerated Aging

Loss of lumbar disc height with age and its impact on pain and sensitivity associated behaviors in mice

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