Exhaustive Variant Interaction Analysis using Multifactor Dimensionality Reduction
Gonzalo Gómez-Sánchez,
Lorena Alonso,
Miguel Ángel Pérez
et al.
Abstract:One of the main goals of human genetics is to understand the connections between genomic variation and the predisposition to develop a complex disorder. These disease-variant associations are usually studied in a single independent manner, disregarding the possible effect derived from the interaction between genomic variants. In particular, in a background of complex diseases, these interactions can be directly linked to the disorder and may play an important role in disease development. Although their study h… Show more
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