Exhaustive Exercise Does Not Affect Humoral Immunity and Protection after Rabies Vaccination in a Mouse Model

Abstract

Rabies is one of the most dangerous and widespread zoonosis and is characterized by severe neurological signs and a high case-mortality rate of nearly 100%. Vaccination is the most effective way to prevent rabies in humans and animals. In this study, the relationship between exhaustive exercise and the humoral immune response after immunization with inactivated rabies vaccine was investigated in a mouse model with one-time exhaustive exercise. It was found that compared with the mice with no exercise after vaccination, no significant differences were found in those with exhaustive exercise after vaccination on body-weight changes, virus-neutralizing antibody (VNA) titers, antibody subtypes and survivor ratio after lethal rabies virus (RABV) challenge. This study indicated that exhaustive exercise does not reduce the effects of the rabies inactivated vaccine.

Mapeamento Potencial de Superfície Corporal durante a Despolarização Ventricular em Ratos Após Exercício Exaustivo Agudo

“…6,7 Nesse sentido, a vantagem dos modelos animais (por exemplo, ratos, camundongos) na avaliação de respostas fisiológicas a exercícios exaustivos é que existem critérios objetivos para a definição de exaustão, como a incapacidade de um animal continuar correndo apesar dos estímulos externos durante um teste de corrida em esteira 8,9 ou afundar em uma piscina durante um teste de natação forçada. 10 Numerosos estudos em animais de laboratório mostraram danos ao tecido miocárdico e comprometimento da função cardíaca associados à apoptose de cardiomiócitos, estresse oxidativo e respostas inflamatórias após episódios agudos de exercício exaustivo. [11][12][13] É relatado que o exercício exaustivo agudo causa alterações nos padrões eletrocardiográficos em ratos, sugerindo alterações na despolarização ventricular.…”

Repetitive Bouts of Exhaustive Exercise Induces a Systemic Inflammatory Response and Multi-Organ Damage in Rats

“…In animal models, exhaustive exercise has typically been evaluated by treadmill running or forced swimming exercises. In these paradigms, animals are said to be exhausted when they refuse to continue running, lack coordinated movements, or sink to the bottom of the pool (Huang et al, 2013;Yan and Hao, 2016;Xia et al, 2018). The harmful effects of exhaustive exercise are pervasive across a variety of body systems, including musculoskeletal, cardiovascular, pulmonary, hematologic, metabolic, and gastrointestinal.…”