Exhaled VOC Biomarkers from Rats Injected with PMs from Thirty-One Major Cities in China

Xing, Qisong; Zhang, Lu; Liu, Huaying; Zhu, Chenyu; Yao, Maosheng

doi:10.1021/acs.est.3c06074

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Overall, exposure to DCM extracts of PM 2.5 from Guangzhou revealed a higher potential for inducing lipid accumulation in HepG2 cells. Toxicology experiments demonstrated correlations between the effects of PM 2.5 and its contributing sources or composition. − Additionally, the impact of inhaling concentrated ambient particles on experimental animals varies with the daily PM 2.5 composition. , Given the equivalent exposure concentrations and time in this study, the observed differences could be because of variations in the toxic components of PM 2.5 . Therefore, it is necessary to comprehensively evaluate the dominant toxic components of PM 2.5 involved in hepatocyte lipid accumulation.…”

Section: Resultsmentioning

confidence: 76%

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis

Yan,

Qin,

Shi

et al. 2024

Environ. Sci. Technol.

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Hepatic steatosis is the first step in a series of events that drives hepatic disease and has been considerably associated with exposure to fine particulate matter (PM 2.5 ). Although the chemical constituents of particles matter in the negative health effects, the specific components of PM 2.5 that trigger hepatic steatosis remain unclear. New strategies prioritizing the identification of the key components with the highest potential to cause adverse effects among the numerous components of PM 2.5 are needed. Herein, we established a high-resolution mass spectrometry (MS) data set comprising the hydrophobic organic components corresponding to 67 PM 2.5 samples in total from Taiyuan and Guangzhou, two representative cities in North and South China, respectively. The lipid accumulation bioeffect profiles of the above samples were also obtained. Considerable hepatocyte lipid accumulation was observed in most PM 2.5 extracts. Subsequently, 40 of 695 components were initially screened through machine learning-assisted data filtering based on an integrated bioassay with MS data. Next, nine compounds were further selected as candidates contributing to hepatocellular steatosis based on absorption, distribution, metabolism, and excretion evaluation and molecular dockingin silico. Finally, seven components were confirmed in vitro. This study provided a multilevel screening strategy for key active components in PM 2.5 and provided insight into the hydrophobic PM 2.5 components that induce hepatocellular steatosis.

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Section: Resultsmentioning

confidence: 76%

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis

Yan,

Qin,

Shi

et al. 2024

Environ. Sci. Technol.

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Exhalation metabolomics: A new force in revealing the impact of ozone pollution on respiratory health

Tao,

Mettke,

Wang

et al. 2024

Eco-Environment & Health

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A review of disrupted biological response associated with volatile organic compound exposure: Insight into identification of biomarkers

Shen,

Liu,

et al. 2024

Science of The Total Environment

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Exhaled VOC Biomarkers from Rats Injected with PMs from Thirty-One Major Cities in China

Cited by 3 publications

References 46 publications

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis

Exhalation metabolomics: A new force in revealing the impact of ozone pollution on respiratory health

A review of disrupted biological response associated with volatile organic compound exposure: Insight into identification of biomarkers

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Exhaled VOC Biomarkers from Rats Injected with PMs from Thirty-One Major Cities in China

Cited by 3 publications

References 46 publications

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM2.5 Associated with Hepatocellular Steatosis

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM2.5 Associated with Hepatocellular Steatosis

Exhalation metabolomics: A new force in revealing the impact of ozone pollution on respiratory health

A review of disrupted biological response associated with volatile organic compound exposure: Insight into identification of biomarkers

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Product

Resources

About

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis

Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM_2.5 Associated with Hepatocellular Steatosis