Exhaled nitrite/nitrate levels as a marker of respiratory complications after heart valve surgery

Early Effect of Tidal Volume on Lung Injury Biomarkers in Surgical Patients With Healthy Lungs

“…EBC nitrate reflects the severity of asthma better than nitrite or exhaled nitric oxide 56 . Our observed nitrite and nitrate concentrations in EBC were comparable to those found in healthy humans 23,54,57 , suggesting healthy lung conditions during our study period. An insufficient time or intensity of the mechanical insult may explain the absence of significant changes in EBC nitrite or nitrate in our study patients.…”

“…The nitrite and nitrate levels in exhaled breath condensate (EBC), representing the metabolism of nitric oxide in the lung, have been measured frequently for assessing lung injury in patients breathing spontaneously or ventilated in the ICU 2,6,21,22 and after cardiothoracic surgery [23][24][25] . Nitrite concentration in the EBC showed a positive correlation with V T in ICU patients with or without ARDS 6 , and with the degree of lung overdistention in chronic obstructive pulmonary disease (COPD) patients 26 .…”

Exhaled Breath Condensate Nitrate Levels are Inversely Associated with the Body Mass Index of Patients without Respiratory Disease

“…Nitrate constitutes the most oxidized NO metabolite ( Figure 1) and while nitrite can be reduced to NO by different cell types, human cells cannot reduce nitrate to nitrite [31]. Both nitrite and nitrate have been measured before in EBC samples from spontaneously breathing patients, and our results are similar to reported levels from healthy adults [35][36][37]. The decreased NO production and nitrosative stress in EBC of obese patients without respiratory disease has not been previously reported.…”

EXHALED AND PLASMA NITRITE: a comparative study among healthy, cirrhotic and liver transplant patients

“…Nitric oxide, diagnostic use. worth mentioning that exhaled NO expresses microcirculatory phenomena better than the measurement of NO 2 -levels in plasma samples collected from the pulmonary artery. Hence, assessment of exhaled NO may be more representative of vasoreactvity in the case of pulmonary hypertension.…”

“…The plasma was deproteinated and stored at -70ºC for later NO 2 -level measurement. The plasma and EBC concentrations of NO 2 -were performed by chemiluminescence (Nitric Oxide Analyzer, 280i, brand-SIEVERS-Sievers NOA) (2,3,13) .The data were presented as mean ± standard deviation. To compare groups of data dosages of plasma and EBC NO 2 -, one-way analysis of variance (one-way ANOVA) with Games-Howell post-test were used.…”