Exhaled nitric oxide levels correlate with measures of disease control in asthma

Comparison of Orally Exhaled Nitric Oxide in Allergic versus Nonallergic Rhinitis

“…30 However, in difficult-to-treat asthma, use of eNO measurement to guide asthma management, and maintenance would be beneficial in increasing asthma control and would result in reduced cost as well. 31 In an adult study, FeNO could be decreased in a dosedependent manner by inhaled corticoidsteroids, 32 but nasal corticosteroid treatment was not found to lower airway inflammation in a pediatric population. 7 The short duration of pharmacotherapy may have explained such conflicting effects.…”

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease

“…3 FeNO has been correlated with indicators of asthma control, such as asthma symptoms, dyspnea score, the use of rescue medications, and the reversibility of airflow obstruction. 47 Some reports suggest that FeNO predicts the likelihood of ICS responsiveness more consistently than spirometry, bronchodilator response or methacholine bronchial challenge tests. 8 In the ATS/ERS guidelines, FeNO <25 ppb in children is suggested as a strong indicator of unlikely ICS responsiveness, whereas FeNO >35 ppb in children as a strong indicator of likely ICS responsiveness.…”

Relationship between Exhaled Nitric Oxide and Levels of Asthma Control in Asthma Patients Treated with Inhaled Corticosteroid

“…That implies that indexes reflecting airway inflammation such as FeNO should be considered along with the current markers of the asthma control to assess the control including various aspects of asthma and to decide a phase of therapy. Although some studies investigated the correlation of FeNO with the overall asthma control, the correlation has not been determined [9][10][11][12][13][14][15] . Sippel et al 9 insisted that FeNO was related with asthma symptoms, the frequency of use of short acting bronchodilators and the response to bronchodilator in 100 children and adults with asthma, to reflect the asthma control but they did not confirm its correlation with the overall level of asthma control.…”

“…Although some studies investigated the correlation of FeNO with the overall asthma control, the correlation has not been determined [9][10][11][12][13][14][15] . Sippel et al 9 insisted that FeNO was related with asthma symptoms, the frequency of use of short acting bronchodilators and the response to bronchodilator in 100 children and adults with asthma, to reflect the asthma control but they did not confirm its correlation with the overall level of asthma control. Senna et al 10 analyzed the correlation of FeNO with FEV 1 , severity and ACT score in 27 patients aged 16∼57 years newly diagnosed as asthma and found a significant correlation of FeNO with ACT and severity (r=0.69, p=0.001).…”

“…However, guidelines for asthma management including GINA consider pulmonary function or an index of airway obstruction importantly but do not reflect FeNO or an index of airway inflammation, in the assessment of the asthma control which is critical to its management. It is still controversial whether FeNO is significantly related with the asthma control as a concept for comprehensive assessment of asthma [9][10][11][12][13][14][15] . This study aims to investigate the correlation between FeNO and the level of asthma control in patients treated for asthma.…”