Exhaled nitric oxide: Interactions between asthma, hayfever, and atopic dermatitis in school children

Abstract

FeNO is not a valuable tool for the detection of asthma in the community as it is confounded by other atopic conditions.

Association between the Results of the Childhood Asthma Control Test and Objective Parameters in Asthmatic Children

“…However, it is well known that the FeNO levels of asthmatic children are associated with comorbid conditions such as allergic rhinitis and atopic dermatitis (17). It is also known that there is a wide interindividual variability in FeNO values (18). These facts might explain why several studies using non-individual FeNO cutoff values to determine optimal ICS doses for the long-term asthma management resulted in even higher maintenance doses in the FeNO-guided group compared with those in the conventional treatment group (19,20).…”

Swimming pool attendance and risk of asthma and allergic symptoms in children

“…It should be noted that in the two studies where pool attendance was positively associated with increased asthma risk [11,12], the asthma definition was partly based on the level of fractional exhaled nitric oxide (FeNO), a marker of allergic airway inflammation. However, FeNO is not specific for asthma and it may be an indicator of atopic diseases including atopic dermatitis or eczema [31].…”

Fractional Exhaled Nitric Oxide in Relation to Asthma, Allergic Rhinitis, and Atopic Dermatitis in Chinese Children

“…Moreover, there were studies stating that the asthma and AD group recorded significantly higher FeNO levels than the asthma-only group (13). High FeNO levels in the AD subjects indicated the presence of potential airway inflammation, which could be a risk factor for developing AR and asthma later in life based on the concept of atopic march (15).…”

“…In the case of equal levels of positive skin prick tests, asthmatic children had higher FeNO than non-asthmatic ones (7). Atopy or allergic diseases [such as allergic rhinitis (AR) or atopic dermatitis (AD)] have been reported as potential factors confounding the relationship between FeNO and asthma (7,12,13). Atopic asthmatics had higher FeNO levels than non-atopic asthmatics, and no difference was detected between non-atopic asthmatics and non-asthmatics, whether atopic or not (5).…”