Exhaled Nitric Oxide in Pulmonary Diseases

Barnes, Peter J.; Dweik, Raed A.; Gelb, Arthur F.; Gibson, Peter G.; George, Steven C.; Grasemann, Hartmut; Pavord, Ian D.; Ratjen, Félix; Silkoff, Philip E.; Taylor, D. Robin; Zamel, Noé

doi:10.1378/chest.09-2090

Cited by 349 publications

(302 citation statements)

References 110 publications

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“…This inflammation could be associated with environmental exposure from the snow crab processing. Previous studies showed that FeNO did not have any diagnostic value in non-eosinophilic asthma (30)(31)(32) ; therefore, when a subject had a FeNO value smaller than 25 ppb, we were unable to exclude the presence of asthma.…”

Section: Discussionmentioning

confidence: 91%

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

et al. 2016

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: Objectives : Few reports are available concerning the prevalence of asthma among snow crab workers in Japan. The object of this study was to estimate the prevalence of asthma and wheezes among Japanese snow crab workers and their associations with exhaled nitric oxide (FeNO) and YKL-40. Methods : Forty-nine snow crab workers enrolled in this study, which was cross -sectional by design and was conducted using a translated version of the European Community Respiratory Health Survey questionnaire. The levels of FeNO and serum YKL-40 were measured between September and October 2014. Results : The prevalences of current asthma and wheezes were 10.2% % (95% % CI, 3.4 to 22.2) and 12.2% % (95% % CI, 4.6 to 24.8), respectively. There was no association between these prevalences and the duration of snow crab employment. Six subjects' FeNO levels exceeded 50 ppb, and nine subjects' levels exceeded 25 ppb. Twelve subjects' (25.5% %) serum YKL-40 levels exceeded 77.2 ng/mL, which was 2 standard deviations above the mean for healthy subjects. However, there were no significant relationships among the prevalences for asthma and wheezes, FeNO, and serum YKL-40. Conclusions : This study provides information concerning the prevalences of asthma and wheezes among Japanese snow crab processing workers.

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Section: Discussionmentioning

confidence: 91%

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

et al. 2016

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“…By monitoring the expiratory flow, it is possible to differentiate selectively between NO from the conducting airways and that coming from the respiratory zone (alveolar NO). The detection of alveolar NO is associated with nocturnal asthma, symptomatic asthmatics and asthmatics with more severe disease [8,52]. Moreover, alveolar NO is more sensitive to oral than to inhaled corticosteroids, suggesting that it may represent true abnormalities of peripheral airways, which are better reached by systemic drugs than by conventional inhaled formulations [20].…”

Section: Biological Assessment Of Peripheral Airwaysmentioning

confidence: 99%

Assessing and accessing the small airways; implications for asthma management

Scichilone

Contoli

Paleari

et al. 2013

Pulmonary Pharmacology & Therapeutics

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a b s t r a c tDespite the wealth of experience in the management of asthma, the disease remains inadequately controlled in some patients, who face long-term respiratory impairment and disability. The disease has been characterised as an inflammatory condition affecting first the larger airways and eventually the smaller airways, but there is evidence that peripheral airway involvement defines a particular and more severe phenotype of asthma. For this reason, assessing functional and biological parameters reflective of small airways involvement is important prognostically. No assessment method is universally and directly representative of peripheral airway function, but the traditional spirometric tests, including vital capacity, residual volume and forced vital capacity, are somewhat correlated with this function; useful methods for further assessment include the single-breath nitrogen wash-out test, impulse oscillometry, nitrous oxide and exhaled breath concentrate measurements, as well as computed tomography to reflect air trapping and response to treatment. Formulation advancements have made for easier treatment access to the smaller airways, with the new extrafine formulations resulting in better asthma control compared with non-extrafine formulations.

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“…Nitric oxide is generated by epithelial cells and is increased in the presence of airway inflammation. 17 A number of studies have used exhaled nitric oxide to detect underlying airway inflammation. The test is noninvasive, reproducible, and standardized.…”

Section: What Other Indicators or Biomarkers Exist To Indicate Airwaymentioning

confidence: 99%

What Is the Best Pulmonary Diagnostic Approach for Wheezing Patients With Normal Spirometry?

Busse

2012

Respir Care

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Asthma is characterized by airway inflammation, airway hyper-responsiveness (AHR) and variable air flow obstruction. The diagnosis of asthma, however, is often based upon nonspecific clinical symptoms of cough, wheeze, and shortness of breath. Furthermore, the physical examination and measurements of pulmonary function are often unremarkable in patients with asthma, thereby complicating the diagnosis of the disease. The following discussion will review approaches to the diagnosis of asthma when lung functions are normal, and will largely focus on the use of bronchial provocation tests to detect underlying AHR.

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Exhaled Nitric Oxide in Pulmonary Diseases

Cited by 349 publications

References 110 publications

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

Assessing and accessing the small airways; implications for asthma management

What Is the Best Pulmonary Diagnostic Approach for Wheezing Patients With Normal Spirometry?

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