Exhaled Nitric Oxide in Acute Respiratory Syncytial Virus Bronchiolitis

Gadish, Tal; Soferman, Ruth; Merimovitch, Tamar; Fireman, Elizabeth; Sivan, Yakov

doi:10.1001/archpediatrics.2010.128

Cited by 28 publications

(32 citation statements)

References 52 publications

(114 reference statements)

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“…He found lower FENO values in the acute phase of bronchiolitis with respect to the other groups. 16 Gadish et al 17 obtained the same results. They measured fractional FENO levels in infants during acute respiratory syncytial virus (RSV) bronchiolitis and during convalescence, and their study shows that FENO levels during acute RSV bronchiolitis are significantly decreased and levels increase back to normal levels and beyond during convalescence.…”

Section: Discussionmentioning

confidence: 54%

“…25 The consistency of these data is limited by the absence of statistical significance that we mainly attribute to the lack of sample. This sample based on previous similar studies 3,17 was insufficient to determine significant differences but it does show a clear trend in the FENO values. After analyzing the results, we calculated the sample size that would be necessary to determine statistical significance with this study design, and we would need 42 patients in each group (alpha error level 5%, beta error level 20%).…”

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confidence: 99%

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Exhaled Nitric Oxide in Acute Phase of Bronchiolitis and Its Relation with Episodes of Subsequent Wheezing in Children of Preschool Age

Zarza

Osona

Gil-Sanchez

et al. 2012

Pediatric Allergy, Immunology, and Pulmonology

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Background: Fractional exhaled nitric oxide (FENO) levels are increased in children with asthma and in infants with recurrent wheezing, but the role of FENO in the acute phase of bronchiolitis is still not defined. Objective: The aim of this study is to evaluate FENO values in the acute phase of bronchiolitis, compare them with healthy infants, and relate those values with the appearance of other wheezing episodes. Methods: FENO values were determined in infants between 2 months and 2 years affected with RVS bronchiolitis by offline method. The FENO values collected in the acute phase were related with the respiratory clinical symptoms presented in the 2 years following the episode. Results: A total of 30 patients were recruited: 15 in the bronchiolitis group and 15 in the control group. The average of the FENO values in the acute phase was 18.74 ppb (range 2-88) in the bronchiolitis group, and 8.75 ppb (range 2-24) in the control group. However, these results showed no significant statistical differences ( p = 0.176). Nevertheless, we found a positive correlation between the FENO values and the clinical score (Downes) of the bronchiolitis episode ( p = 0.023). In infants that presented other wheezing episodes in the 2 years after, the average of FENO in the acute phase of the first episode was 23.1 ppb (average of 10.25 ppb) versus 8.4 ppb (average 5.4 ppb) in the group of patients with no other episodes. The comparison of averages has no statistical significance. Conclusion: We found no differences in FENO between infants with bronchiolitis and healthy ones. The FENO values in the acute phase seems to be related to the severity of the disease but do not predict the appearance of wheezing episodes in the following 2 years.

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Section: Discussionmentioning

confidence: 54%

mentioning

confidence: 99%

Exhaled Nitric Oxide in Acute Phase of Bronchiolitis and Its Relation with Episodes of Subsequent Wheezing in Children of Preschool Age

Zarza

Osona

Gil-Sanchez

et al. 2012

Pediatric Allergy, Immunology, and Pulmonology

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“…11 Caution should be used when assessing FeNO levels in children with respiratory tract infections because FeNO levels have been shown to vary by phase of the infection and to be different between studies. 15,16 Medications, including inhaled or systemic corticosteroids or leukotriene receptor antagonists, need to be considered as they significantly reduce FeNO levels. 17,18 Serial measurements should be performed at approximately the same time of the day since circadian rhythms may affect FeNO levels.…”

Section: Subject-related Factorsmentioning

confidence: 99%

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease

Kim

Eckel

Kim

et al. 2016

Allergy Asthma Immunol Res

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“…The study of Tsutsumi et al (1999) revealed that in spite the up-regulation of the Inducible Nitric Oxide Synthase (iNOS) in RSV-infected respiratory epithelial cells, NO production specific for RSV infection itself could not be detected by nitrite assay. Moreover, Gadish et al (2010) investigated the Fractional exhaled Nitric Oxide (FeNO) levels in infants during acute RSV bronchiolitis and during convalescence. They found that the FeNO levels were temporarily reduced during acute RSV bronchiolitis and increased during convalescence to normal levels and higher.…”

Section: Discussionmentioning

confidence: 99%

“…Left ventricular diastolic function was assessed by measuring mitral E/A ratio where E and A denote early and late mitral flow, respectively. Systolic left ventricular function was assessed by determining the Fractional Shortening (FS) and Ejection Fraction (EF) (Gadish et al, 2010). Interpretations of these studies were performed an attending cardiologist blinded as to the cTp I and miRNAs results.…”

Section: Echocardiographic Studiesmentioning

confidence: 99%

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

Mohamed¹,

Zayed²

2016

American Journal of Infectious Diseases

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Abstract:Bronchiolitis is an acute inflammatory injury of the bronchioles that is usually caused by a viral infection, most commonly Respiratory Syncytial Virus (RSV). This study aimed to verify the direct injurious effect of acute bronchiolitis on the myocardium and serum level of microRNA-122 and 499 (miR-122 and miR-499) of infected infants. Serum lactate dehydrogenase (LDH), creatine phosphokinase-isoenzyme MB (CK-MB) and cardiac troponin I (cTp I) were significantly elevated in mild to moderate group as well as severe group except cTp I which showed nonsignificant elevation in mild to moderate group, compared to control group. Quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR) was carried out to evaluate the serum level of miR-122 and miR-499. Sharp elevation in serum miR-122 was observed in severe cases, while miR-499 was statistically non-significant as compared to both normal and mild to moderate groups. The flow velocities across the pulmonary, tricuspid and mitral valves were recorded using standard echocardiographic techniques. Echocardiographic data showed significant reduction in pulmonary At/Et ratio in severe bronchiolitis group, compared to both normal and mild to moderate groups, respectively. Parallel reduction was also observed in tricuspid and mitral E/A ratios, compared to both normal and mild to moderate groups, respectively. Severe bronchiolitis causes cardiac dysfunction due to hypoxia, cardiac strain and pulmonary hypertension in addition to up-regulation of serum miRNA-122.

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Exhaled Nitric Oxide in Acute Respiratory Syncytial Virus Bronchiolitis

Cited by 28 publications

References 52 publications

Exhaled Nitric Oxide in Acute Phase of Bronchiolitis and Its Relation with Episodes of Subsequent Wheezing in Children of Preschool Age

Exhaled Nitric Oxide in Acute Phase of Bronchiolitis and Its Relation with Episodes of Subsequent Wheezing in Children of Preschool Age

Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease

Impact of Acute Bronchiolitis on Cardiac Functions and Serum microRNA-122 and 499

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