Exhaled Nitric Oxide in Acute Respiratory Syncytial Virus Bronchiolitis

Abstract

To investigate fractional exhaled nitric oxide (FeNO) levels in infants during acute respiratory syncytial virus (RSV) bronchiolitis and during convalescence.Design: Prospective cohort study. Comparison of FeNO levels between infants with laboratory-confirmed acute RSV bronchiolitis and 2 control groups: healthy infants and infants with recurrent wheezing.

Feasibility of multiple breath washout measurements in infants with bronchiolitis: A pilot study

“…Exhaled NO is raised in asthma, but findings are controversial regarding acute bronchiolitis. Levels were unchanged in one study, but were decreased in another compared to healthy controls or infants with recurrent wheezing, normalizing during convalescence . Our findings support the latter study.…”

Viral etiology and atopic characteristics in high-risk asthmatic children hospitalized for lower respiratory tract infection

“…Notably, Konradsen et al (7) found that when the interference of allergic factors was excluded, the FeNO of children with viral LRTI, increased after the viral infection was controlled, regardless of whether it was accompanied by wheezing or not. This is like the "rebound phenomenon" observed by Gadish et al (26). In the present study, the observed low FeNO level after viral infection may be due to the restriction imposed by bronchial spasms in the acute stage of wheezing.…”

A possible way to assess tidal exhaled nitric oxide in neonates and infants treated with nasal continuous positive airway pressure

“…The low exhaled NO values in the bronchiolitis group (mean 1.8 ppb) were in concordance with those reported by Gadish et al. . This strengthens our procedure of exhaled NO measurements in connection with nasal CPAP treatment.…”