Exhaled Nitric Oxide

Hoyte, Flavia; Gross, Lara; Katial, Rohit

doi:10.1016/j.iac.2018.06.001

Cited by 42 publications

(42 citation statements)

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“…Animal studies have shown that at lower concentrations, NO has a bronchodilator effect, but at higher levels NO has a pro‐inflammatory action. The increased levels of NO observed in disease states caused by airway inflammation are thought to be the result of increased induction of nitric oxide synthease and of increased reactive nitrosylation pathways …”

Section: Introductionmentioning

confidence: 99%

“…Fractional exhaled nitic oxide (FeNO) has been demonstrated to be a useful biomarker of eosinophilic airway inflammation. FeNO levels can be easily measured non‐invasively by a single‐breath exhalation technique and, through utilizing mathematical airway modelling, is thought to provide a representation of distal airway inflammation . Although commonly thought of as an eosinophilic disease, airway inflammation in asthma can also be neutrophilic in origin .…”

Section: Introductionmentioning

confidence: 99%

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Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

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Background Decreased lung function is common in preterm‐born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm‐born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term‐born controls. Methods We searched eight databases up to February 2018. Studies comparing FeNO levels in preterm‐born subjects (<37 weeks’ gestation) in childhood and adulthood with and without (CLD) with term‐born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3. Results From 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in preterm‐ and term‐born children and adults; 11 studies (preterm n = 640 and term n = 4005) were included in a meta‐analysis. The mean FeNO concentration difference between the preterm‐born and term‐born group was −0.74 (95% CI −1.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm n = 204 and term n = 211) the mean difference for FeNO levels was −2.82 (95% CI −5.87 to 0.22) ppb between the preterm‐born CLD and term‐born groups. Conclusions Our data suggest that preterm born children with and without CLD have similar FeNO levels to term‐born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm‐born subjects.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

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“…Fractional exhaled nitric oxide (FENO) is a non-invasive and reproducible biomarker in the diagnostic algorithm of lung diseases. The asthma guideline has suggested FENO as a marker of airway inflammation to determine the optimal dosage of inhaled corticosteroid [10][11]. Only several studies of FENO in ILDs are available.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Lin¹,

Guo²,

Song³

et al. 2020

Preprint

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Background No established biomarkers are available to guide the treatment of chronic interstitial lung diseases (ILDs). Nitric oxide reflects the inflammation in the airway, and fractional exhaled nitric oxide (FeNO) is a non-invasive and reproducible biomarker in lung-disease diagnosis and treatment. Whether FeNO can help manage ILDs remains uncertain. This study aimed to determine the role of FeNO in ILDs and the association between FeNO and ILD subtype. Methods 53 patients with ILDs were retrospectively recruited. Patient characteristics, FeNO values, blood tests for inflammatory markers, and pulmonary function test data were obtained. ResultsThis group of patients with ILDs had decreased vital capacity(VC)and total lung capacity(TLC) of 71.75 ± 17.58% and 75.27 ± 14.07%, respectively. The diffusion capacity of the lung for carbon monoxide(DLCO) also declined, with an average level of 38.15 ± 11.10%. The average FeNO value was 20.34 ± 9.97 ppb. According to the characteristics of chest computed tomography, patients were divided into usual interstitial pneumonia (UIP)-ILD (n = 24) and non-UIP-ILD (n = 29). The FeNO value in the UIP-ILD group was 12.58 ± 3.63 ppb. This value was significantly lower than that of the non-UIP-ILD group (26.62 ± 8.61 ppb, P<0.0001).According to the etiology, all patients with ILDs were divided into connective tissue diseases associated with interstitial lung disease (CTD-ILD) (n = 30) and non-CTD-ILD (n = 23). There were more female patients in CTD-ILD group compared to non-CTD ILD group and patients in CTD-ILD group were younger. With regard to the FeNO, PFT values, and systemic inﬂammatory markers, no signiﬁcant differences were observed between groups. In the overall ILD population, FeNO level correlated with blood eosinophil (r = 0.3066, P=0.0333), but no statistical significant correlations were observed between the FeNO and blood eosinophil percentage, IgE or systemic inﬂammatory markers. The FeNO cut-off value of 18.5 ppb showed a sensibility of 83.3% and a speciﬁcity of 95.8% in discriminating non-UIP-ILDs from UIP ILDs. Conclusions Our study suggested the importance of FeNO test in patients with ILDs. High FeNO levels may indicate the need of systemic treatment, and FeNO can be a helpful biomarker for ILD management.

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“…The increased levels of NO observed in disease states caused by airway inflammation are thought to be the result of increased induction of nitric oxide synthease and of increased reactive nitrosylation pathways. 6 Fractional exhaled nitic oxide (FeNO) has been demonstrated to be a useful biomarker of eosinophilic airway inflammation. FeNO levels can be easily measured non-invasively by a single-breath exhalation technique and, through utilizing mathematical airway modelling, is thought to provide a representation of distal airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…FeNO levels can be easily measured non-invasively by a single-breath exhalation technique and, through utilizing mathematical airway modelling, is thought to provide a representation of distal airway inflammation. 6 Although commonly thought of as an eosinophilic disease, airway inflammation in asthma can also be neutrophilic in origin. 7 FeNO levels have been shown to be higher in children with asthma and during asthma exacerbations, being associated with increased airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis

Course¹,

Kotecha²

2019

Neonatology and Paediatric Intensive Care

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Background: Decreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term-born controls. Methods: We searched eight databases up to February 2018. Studies comparing FeNO levels in preterm-born subjects (<37 weeks' gestation) in childhood and adulthood with and without (CLD) with term-born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3. Results: From 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in pretermand term-born children and adults; 11 studies (preterm n = 640 and term n = 4005) were included in a meta-analysis. The mean FeNO concentration difference between the preterm-born and term-born group was −0.74 (95% CI −1.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm n = 204 and term n = 211) the mean difference for FeNO levels was −2.82 (95% CI −5.87 to 0.22) ppb between the pretermborn CLD and term-born groups. Conclusions: Our data suggest that preterm born children with and without CLD have similar FeNO levels to term-born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm-born subjects. K E Y W O R D S asthma, bronchopulmonary dysplasia, chronic lung disease of prematurity, FeNO, fractional exhaled nitric oxide, prematurity This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Exhaled Nitric Oxide

Cited by 42 publications

References 86 publications

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis

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