Exhaled Ethane

Kanoh, Soichiro; Kobayashi, Hideo; Motoyoshi, Kazuo

doi:10.1378/chest.128.4.2387

Cited by 89 publications

(42 citation statements)

References 18 publications

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“…The concentrations of SP-A and SP-D are reported to be correlated with the extent of alveolitis (denoted by ground glass opacities on HRCT), but not with the progression of fibrosis (26). Consistent with this observation, we found that the CO-Hb concentration was correlated with the serum levels of SP-A and SP-D and with the PaO 2 , LDH, and CRP values, which are markers of cellular damage and inflammation (18,27). The inflammation index, which was calculated by an HRCT scoring system, has also been reported to be a robust indicator of alveolitis (14).…”

Section: Discussionsupporting

confidence: 85%

“…Oxidative stress has been implicated in the pathogenesis and progression of ILD (16,17) and is reported to be correlated with poor clinical outcomes in subjects with ILD (18). Oxidative stress increases the release of HO-1 from alveolar macrophages, bronchial epithelial cells and inflammatory cells, leading to increased CO-Hb concentrations (4,5,19).…”

Section: Discussionmentioning

confidence: 99%

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Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease

et al. 2017

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Objective The arterial concentration of carboxyhemoglobin (CO-Hb) in subjects with inflammatory pulmonary disease is higher than that in healthy individuals. We retrospectively analyzed the relationship between the CO-Hb concentration and established markers of disease severity in subjects with interstitial lung disease (ILD). Methods The CO-Hb concentration was measured in subjects with newly diagnosed or untreated ILD and the relationships between the CO-Hb concentration and the serum biomarker levels, lung function, highresolution CT (HRCT) findings, and the uptake in gallium-67 ( 67 Ga) scintigraphy were evaluated. Results Eighty-one non-smoking subjects were studied (mean age, 67 years). Among these subjects, (A) 17 had stable idiopathic pulmonary fibrosis (IPF), (B) 9 had an acute exacerbation of IPF, (C) 44 had stable non-IPF, and (D) 11 had an exacerbation of non-IPF. The CO-Hb concentrations of these subjects were (A) 1.5±0.5%, (B) 2.1±0.5%, (C) 1.2±0.4%, and (D) 1.7±0.5%. The CO-Hb concentration was positively correlated with the serum levels of surfactant protein (SP)-A (r=0.38), SP-D (r=0.39), and the inflammation index (calculated from HRCT; r=0.57) and was negatively correlated with the partial pressure of oxygen in the arterial blood (r=-0.56) and the predicted diffusion capacity of carbon monoxide (r=-0.61). The CO-Hb concentrations in subjects with a negative heart sign on 67 Ga scintigraphy were higher than those in subjects without a negative heart sign (1.4±0.5% vs. 1.1±0.3%, p=0.018). Conclusion The CO-Hb levels of subjects with ILD were increased, particularly during an exacerbation, and were correlated with the parameters that reflect pulmonary inflammation.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease

et al. 2017

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“…With regard to human studies, increase of 8-isoprostane, a product of lipid peroxidation induced by free radicals, has been demonstrated in bronchoalveolar lavage fluid of patients with IPF [60], and in exhaled breath condensate [61]. Increase of other markers of oxidative stress, such as NO [62], hydrogen peroxide [61] and ethane [63], was shown in the exhale of IPF patients, and inversely correlated with glutathione levels in alveolar epithelial lining fluid [64] and with extracellular superoxide dismutase [65]. Daniil et al reported that total hydroperoxides, a marker of oxidative burden, were higher in serum of IPF patients than in controls, and negatively correlated with lung function parameters [66].…”

Section: Oxidative Stress and Fibrosis Of The Lung Liver And Kidneymentioning

confidence: 99%

New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis

Gabrielli

Svegliati²,

Moroncini³

et al. 2012

TORJ

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Systemic sclerosis (Scleroderma – SSc) is a connective tissue disorder of unknown aetiology characterized by extensive fibrosis of the skin and visceral organs, by vascular abnormalities and immunological manifestations.Recent evidence suggest that the cellular redox state may play a significant role in the progression of scleroderma fibrosis. Mechanisms involved include an autoamplification circuit linking ROS, Ras and ERK 1-2 which in turn amplifies and maintains the autocrine loop made up by cytokines, growth factors and their cognate receptors.This review summarizes the recent progress on the role of oxidative stress in the pathophysiology of scleroderma and disorders characterised by organ fibrosis

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“…Breath analysis holds a distinguished status in this context as it is non-invasive and breath biomarkers can provide valuable information on disease processes, or metabolic disorders occurring even in distant parts of the body. For instance, volatile compound profiles were shown to be different in lung cancer patients as compared to healthy controls [6-9] and proved to be useful in the quantification of oxidative stress [10,11]. Unfortunately, the origin and metabolic fate of numerous breath VOCs have not been elucidated in sufficient depth, thereby limiting the clinical application of breath tests.…”

Section: Introductionmentioning

confidence: 99%

Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro

et al. 2013

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BackgroundVolatile organic compounds (VOCs) emitted by human body offer a unique insight into biochemical processes ongoing in healthy and diseased human organisms. Unfortunately, in many cases their origin and metabolic fate have not been yet elucidated in sufficient depth, thus limiting their clinical application. The primary goal of this work was to identify and quantify volatile organic compounds being released or metabolized by HepG2 hepatocellular carcinoma cells.MethodsThe hepatocellular carcinoma cells were incubated in specially designed head-space 1-L glass bottles sealed for 24 hours prior to measurements. Identification and quantification of volatiles released and consumed by cells under study were performed by gas chromatography with mass spectrometric detection (GC-MS) coupled with head-space needle trap device extraction (HS-NTD) as the pre-concentration technique. Most of the compounds were identified both by spectral library match as well as retention time comparison based on standards.ResultsA total of nine compounds were found to be metabolised and further twelve released by the cells under study (Wilcoxon signed-rank test, p<0.05). The former group comprised 6 aldehydes (2-methyl 2-propenal, 2-methyl propanal, 2-ethylacrolein, 3-methyl butanal, n-hexanal and benzaldehyde), n-propyl propionate, n-butyl acetate, and isoprene. Amongst the released species there were five ketones (2-pentanone, 3-heptanone, 2-heptanone, 3-octanone, 2-nonanone), five volatile sulphur compounds (dimethyl sulfide, ethyl methyl sulfide, 3-methyl thiophene, 2-methyl-1-(methylthio)- propane and 2-methyl-5-(methylthio) furan), n-propyl acetate, and 2-heptene.ConclusionsThe emission and uptake of the aforementioned VOCs may reflect the activity of abundant liver enzymes and support the potential of VOC analysis for the assessment of enzymes function.

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Exhaled Ethane

Cited by 89 publications

References 18 publications

Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease

Arterial Carboxyhemoglobin Measurement Is Useful for Evaluating Pulmonary Inflammation in Subjects with Interstitial Lung Disease

New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis

Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro

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