Exhaled carbon monoxide is not elevated in patients with asthma or cystic fibrosis

Zetterquist, Wilhelm; Lundberg, Jon O.; Alving, Kjell

doi:10.1183/09031936.02.00078702a

Cited by 5 publications

(7 citation statements)

References 3 publications

(3 reference statements)

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“…CO in air. To standardize the micro CO analysis, each student was asked to exhale completely, inhale fully and then hold the breath for 20 seconds before exhaling rapidly into the disposable mouthpiece [14,20].…”

Section: Methodsmentioning

confidence: 99%

“…Recent data show smoking prevalence in Spain to be one of the highest in the European Union for ages [16][17][18][19][20][21][22][23][24] years and, at 25% for men and 28.8% for women, well above the world-wide average of 22% for this age group [4]. In 2008, 6.1% of boys and 4.5% of girls in the 8th year, 15.8% and 20.4% of those in the 10th year, respectively, and 26.1% and 33.1% of those in the 12th year, respectively, were regular smokers [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of a smoking prevention programme in Catalan secondary schools: a cluster‐randomized controlled trial in Spain

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of a smoking prevention programme in Catalan secondary schools: a cluster‐randomized controlled trial in Spain

et al. 2015

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“…It was found that exhaled CO levels were not affected by different exhalation flow rates. As the central airway is an important factor determining flow dependency [14], this strongly indicates that there is no contribution of CO from airway epithelium, so the origin of CO is from the alveoli. Support for this is also given by the increase in eCO concentrations after breath-holding; with 10-s breath hold, an eCO increase of up to 20 % is observed, while collecting the breath in bags.…”

Section: −1mentioning

confidence: 99%

“…In 1972, Nikberg et al [5] were the first to describe exhaled CO (eCO) as a marker to assess different diseases such as cardiovascular diseases, diabetes, and nephritis. Moreover, high levels of eCO have been observed for many diseases [6,7], such as asthma [8][9][10][11] and cystic fibrosis [12,13], but these findings are still subject of controversy [14].…”

Section: Introductionmentioning

confidence: 99%

Quantum cascade laser-based sensors for the detection of exhaled carbon monoxide

et al. 2016

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“…21,22 Furthermore, Silkoff et al reported a well-documented flow dependency of NO concentrations in exhaled air. 23 By contrast, other reports described that the concentration of CO in expired gas was unaffected by alterations in flow rate in adult asthmatic patients 24 and children with asthma. 25 Pulmonary function tests were not performed in the present study, but we performed expiratory peak flow measurement during asthma attacks in 4 of 22 patients, and found a negative correlation between peak flow rate and exhaled CO concentrations.…”

Section: Discussionmentioning

confidence: 89%

Exhaled carbon monoxide levels in school‐age children with episodic asthma

Ohara

Ohrui

Morikawa

et al. 2006

Pediatric Pulmonology

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Carbon monoxide (CO) can be detected in exhaled air and is increased in adult and childhood persistent asthmatic patients. However, little is known about the exhaled CO concentration in episodic childhood asthma. This study aimed to clarify whether measurement of exhaled CO is useful in monitoring disease activity in children with episodic asthma. We measured exhaled CO concentration by modified Micro-Smokerlyzer in 217 elementary school children (132 boys; mean age, 10 +/- 1 (SE) years; range, 9-12 years), in whom 29 had infrequent episodic asthma without current exacerbations. We also measured exhaled CO concentrations in 22 children with episodic asthma (13 boys; mean age, 10 +/- 3 years; range, 8-12 years), who had acute mild asthmatic attacks during examination. In these patients with mild asthmatic attacks, exhaled CO was measured both before and after combination therapy with salbutamol and sodium cromoglycate (SCG) by powered nebulizer. Among 217 schoolchildren, exhaled CO levels in infrequent episodic asthmatic children (1.1 +/- 0.1 parts per million (ppm), n = 29) were not significantly different from those in healthy schoolchildren (1.0 +/- 0.1 ppm, n = 188, P > 0.68). The exhaled CO concentrations during asthma attacks in children with episodic asthma were significantly higher (5.1 +/- 0.4 ppm, n = 22) compared with those in healthy children (P < 0.001) or those in asymptomatic asthmatic children (P < 0.001). The elevated exhaled CO levels were significantly decreased after inhalation therapy of a combination of salbutamol and SCG (3.2 +/- 0.5 ppm, n = 22, P < 0.02). In conclusion, exhaled CO levels were significantly elevated during acute asthma exacerbations, and partially recovered after treatment with beta(2)-agonist and SCG in children with mild episodic asthma. These findings indicate that measurement of exhaled CO might provide another noninvasive measurement of asthma exacerbations that would be suitable for use in children with acute mild episodic asthma.

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Exhaled carbon monoxide is not elevated in patients with asthma or cystic fibrosis

Cited by 5 publications

References 3 publications

Efficacy of a smoking prevention programme in Catalan secondary schools: a cluster‐randomized controlled trial in Spain

Efficacy of a smoking prevention programme in Catalan secondary schools: a cluster‐randomized controlled trial in Spain

Quantum cascade laser-based sensors for the detection of exhaled carbon monoxide

Exhaled carbon monoxide levels in school‐age children with episodic asthma

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