Exhaled breath analysis: physical methods, instruments, and medical diagnostics

Вакс, В. Л.; Домрачева, Е. Г.; Sobakinskaya, E. A.; Chernyaeva, M. B.

doi:10.3367/ufne.0184.201407d.0739

Cited by 44 publications

(17 citation statements)

References 97 publications

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“…The AuNPs@deSG‐SS embedded membrane paper sensor is further tested as a flexible device for detecting human breathing and sweating. Such tests are significant considering the facts that human breathing relates the physical conditions or performances, and that the human breath exhale contain various volatiles (e.g., under normal conditions, 5% H 2 O vapor, a few ppm (V) of H 2 , CO 2 , and NH 3 , and ≈1 ppm (V) of acetone, methanol, ethanol, and other VOCs) which can be used to diagnose some conditions related to human health, such as lung cancer and diabetes . The pattern of exhale breath is either a strong predictor of diseases such as colorectal cancer and gastric cancer, or used as a unique breath print for illnesses such as chronic obstructive pulmonary disease, pneumonia, and asthma .…”

Section: Resultsmentioning

confidence: 99%

Decoration of Nanofibrous Paper Chemiresistors with Dendronized Nanoparticles toward Structurally Tunable Negative‐Going Response Characteristics to Human Breathing and Sweating

Yan

Liu

Skeete

et al. 2017

Adv Materials Inter

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The development of wearable breath or sweat sensor arrays for human performance monitoring is increasingly important for providing personalized health information under various environmental conditions. A major challenge is the lack of sensing elements responsive uniquely to moisture‐dominated breathing and sweating processes, which is critical for differentiating other chemical or biological species from the moisture‐dominated environment. Here a novel class of nanofibrous paper chemiresistors decorated with dendronized nanoparticles that exhibit structurally tunable and negative‐going responses to human breathing and sweating is reported. The nanocomposite device features flexible membrane‐type scaffold derived from multilayered nanofibrous paper as a biocompatible matrix and dendronized gold nanoparticles with tunable sizes and shapes to enable structural diversity and molecular sensitivity. Key elements of novelty include the immobilization of poly(ether‐ester) dendrons with oligoethylene glycol spacers on gold nanoparticles and the combination of hydrogen bonding and van der Waals interactions between partially interpenetrating dendrons, leading to tunable and unique response characteristics to breathing and sweating processes. The results demonstrate the first example of nanofibrous paper chemiresistors decorated with dendronized nanoparticles as a promising new strategy toward constructing sensing interfaces for wearable breath and sweat sensors.

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Section: Resultsmentioning

confidence: 99%

Decoration of Nanofibrous Paper Chemiresistors with Dendronized Nanoparticles toward Structurally Tunable Negative‐Going Response Characteristics to Human Breathing and Sweating

Yan

Liu

Skeete

et al. 2017

Adv Materials Inter

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“…Furthermore, light molecules with molecular masses below 35 g/mol, such as methanol, are challenging or not even possible to detect. Extensive overviews about breath analysis techniques are given elsewhere [11,22].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy

Rothbart

Holz

Koczulla

et al. 2019

Sensors

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Breath gas analysis is a promising tool for medical research and diagnosis. A particularly powerful technological approach is millimeter-wave/terahertz (mmW/THz) spectroscopy, because it is a very sensitive and highly selective technique. In addition, it offers the potential for compact and affordable sensing systems for wide use. In this work, we demonstrate the capability of a mmW/THz spectrometer for breath analysis. Samples from three volunteers and a sample from ambient air were analyzed with respect to 31 different molecular species. High-resolution absorption spectra were measured by scanning two absorption lines from each species. Out of the 31, a total of 21 species were detected. The results demonstrate the potential of mmW/THz spectroscopy for breath analysis.

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“…The PhS mode allows measurements at a certain frequency, which is necessary for observing behavior of the selected substances (increase or decrease of gas concentration) [11].…”

Section: Two-frequency Thz Spectroscopymentioning

confidence: 99%

“…The frequency scanning mode can be used to study the composition of a mixture or to simultaneously measure the concentrations of several gases. Wide-range measurements in the scanning mode allow simultaneous recording of the absorption lines of several gases for a few fractions of a second [11], [20].…”

Section: Two-frequency Thz Spectroscopymentioning

confidence: 99%

Two-Frequency THz Spectroscopy for Analytical and Dynamical Research

Yablokov

Anfertev

Revin

et al. 2015

IEEE Trans. THz Sci. Technol.

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Development of high-sensitivity and high resolution analytical spectroscopy is an area of active research interest currently. In the paper a method of two-frequency THz spectroscopy is presented. A laboratory model of spectrometer using two independent radiation sources of 118-178 GHz and 330-390 GHz ranges and a single detector with 500-2500 V/W sensitivity is presented. Test measurements allowed detecting two gases simultaneously with the minimal registration period of 4 s and the hardware resolution of 1 kHz. These experiments proved this new trend in analytical spectroscopy to have wide application prospects for a variety of fundamental and applied scientific problems. In the first place, it is laboratory modeling of the processes of atmospheric and space chemistry, studying of their dynamics as well as transformations and changes of mixture composition. Besides, the proposed method can be applied to investigations of fast processes, detection of intermediate and short-lived products of chemical reactions.Index Terms-High resolution transient spectroscopy, phase switching, terahertz (THz) frequency range, two-frequency spectrometer.

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Exhaled breath analysis: physical methods, instruments, and medical diagnostics

Cited by 44 publications

References 97 publications

Decoration of Nanofibrous Paper Chemiresistors with Dendronized Nanoparticles toward Structurally Tunable Negative‐Going Response Characteristics to Human Breathing and Sweating

Decoration of Nanofibrous Paper Chemiresistors with Dendronized Nanoparticles toward Structurally Tunable Negative‐Going Response Characteristics to Human Breathing and Sweating

Analysis of Human Breath by Millimeter-Wave/Terahertz Spectroscopy

Two-Frequency THz Spectroscopy for Analytical and Dynamical Research

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