Exhaled Biomarkers and Gene Expression at Preschool Age Improve Asthma Prediction at 6 Years of Age

Klaassen, Ester M.M.; Kant, Kim D. G. van de; Jöbsis, Quirijn; Schayck, Onno C. P. van; Smolinska, Agnieszka; Dallinga, Jan W.; Schooten, Frederik J. van; Hartog, G.J.M. den; Jongste, Johan C. de; Rijkers, Ger T.; Dompeling, Edward

doi:10.1164/rccm.201408-1537oc

Cited by 74 publications

(94 citation statements)

References 44 publications

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“…The ucAPI also included a medical diagnosis of eczema and physician-diagnosed allergic rhinitis as a major and a minor criterion, respectively 9. Medical diagnosis of eczema as a major and allergic rhinitis as a minor criterion were used in the ADEM API 23. Caudri et al followed 3963 children for 8 years in the PIAMA birth cohort in order to develop a score for predicting the risk of asthma at 7–8 years of age.…”

Section: Resultsmentioning

confidence: 99%

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Rodríguez‐Martínez¹,

Sossa-Briceño²,

Castro-Rodriguez³

2017

JAA

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BackgroundFor the early identification of persistent asthma symptoms among young children with recurrent wheezing, it would be helpful to identify all available studies that have identified at least one factor for predicting the persistence of early wheezing. The objective of the present study was to perform a systematic review of all studies that have identified factors that predict the persistence of symptoms among young patients with recurring wheezing.MethodsA systematic review of relevant studies was conducted through searching in MEDLINE, EMBASE, CINHAL, and SCOPUS databases up to June 2016. Studies that identified predictors of persistence of wheezing illness among young children with recurrent wheezing were retrieved. Two independent reviewers screened the literature and extracted relevant data.ResultsThe literature search returned 649 references, 619 of which were excluded due to their irrelevance. Five additional studies were identified from reference lists, and 35 studies were finally included in the review. Among all the identified predictors, the most frequently identified ones were the following: family asthma or atopy; personal history of atopic diseases; allergic sensitization early in life; and frequency, clinical pattern, or severity of wheezing/symptoms.ConclusionParental asthma (especially maternal), parental allergy, eczema, allergic rhinitis, persistent wheezing, wheeze without colds, exercise-induced wheeze, severe wheezing episodes, allergic sensitization (especially polysensitization), eosinophils (blood or eosinophil cationic protein in nasal sample), and fraction of exhaled nitric oxide were risk factors predicting persistence of early wheezing through school age. All of them are included in conventional algorithms, for example, Asthma Predictive Index and its modifications, for predicting future asthma.

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Section: Resultsmentioning

confidence: 99%

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Rodríguez‐Martínez¹,

Sossa-Briceño²,

Castro-Rodriguez³

2017

JAA

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“…In previous studies, these markers have been separately associated with childhood asthma [26,27]. In order to assess whether exhaled biomarkers, expression of inflammatory genes and early lung function measurements can improve a reliable asthma prediction in preschool wheezy children, KLAASSEN et al [28] evaluated 202 children, aged 2-4 years, from the Asthma Detection and Monitoring (ADEM) cohort, and prospectively followed them yearly until 6 years of age. At the time of recruitment, clinical patient characteristics, airway resistance, EBC, VOC and RNA from peripheral blood mononuclear cells were obtained.…”

Section: Viral Wheeze Exhaled Biomarker Profiles and Prediction Of Amentioning

confidence: 99%

“…Although the results of this study require further validation by studies involving other populations of children and adolescents with asthma and a longer follow-up, information on individual patients might be beneficial in strategies to prevent seasonal events and might help to achieve a more complete, systematic and personalised approach to asthma management. Reproduced from [28] with permission from the publisher.…”

Section: Asthmatic Exacerbationsmentioning

confidence: 99%

Asthma in childhood

Benedictis

Attanasi

2016

Eur Respir Rev

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Several topics on childhood asthma were addressed in the Paediatric Clinical Year in Review session at the 2015 European Respiratory Society International Congress. With regard to the relationship between lower respiratory tract infections and asthma, it emerges that is the number of respiratory episodes in the first years of life, but not the particular viral trigger, to be associated with later asthma development. Understanding which characteristics of individual patients are associated with an increased risk for asthma exacerbation is a critical step to implement strategies preventing these seasonal events. Recent data suggest the possibility that exhaled volatile organic compounds may qualify as biomarkers in detecting early signs of asthma. Adding information of exhaled volatile organic compounds and expression of inflammation genes to a clinical tool significantly improves asthma prediction in preschool wheezy children. Personal communication with children and adolescents is likely more important than the tools actually used for monitoring asthma. Systemic corticosteroids do not affect the long-term prognosis in children with first viral-induced wheezing episode and should be used cautiously during acute episodes. Finally, stress and a polymorphism upstream of a specific gene are both associated with reduced bronchodilator response in children with asthma. @ERSpublications New research reports must be integrated into medical communication to assist clinicians to improve asthma management http://ow.ly/XACHS

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“…Early-life production of LPS-stimulated tumor necrosis factor-α (TNF) but not IL-6, IL-10 or IL-12 by PBMCs from infants was associated with a higher risk for developing asthma 97 . Combined exhaled volatile organic compounds, PBMC inflammatory gene expression (TLR4, catalase and TNF), and clinical information (asthma predictive index) in preschool age children could predict asthma at 6 years of age 98 .…”

Section: Allergymentioning

confidence: 99%

Immune biomarkers in the spectrum of childhood noncommunicable diseases

Skevaki

Berg

Jones

et al. 2016

Journal of Allergy and Clinical Immunology

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A biomarker is an accurately and reproducibly quantifiable biological characteristic that provides an objective measure of health status or disease. Benefits of biomarkers include identification of therapeutic targets, monitoring of clinical interventions, and development of personalized (or precision) medicine. Challenges to the use of biomarkers include optimizing sample collection, processing and storage, validation, and often the need for sophisticated laboratory and bioinformatics approaches. Biomarkers offer better understanding of disease processes and should benefit the early detection, treatment and management of multiple non-communicable diseases (NCDs). This review will consider the utility of biomarkers in allergic and other immune mediated diseases in childhood. Typically, biomarkers are used currently to provide mechanistic insight or an objective measure of disease severity with their future role in risk stratification/disease prediction speculative at best. There are many lessons to be learned from the biomarker strategies used for cancer where biomarkers are in routine clinical use and industry wide standardized approaches have been developed. Biomarker discovery and validation in childhood disease lags behind that for adults; given the early onset and therefore potential lifelong impact of many NCDs there should be more studies incorporating cohorts of children. Many pediatric biomarkers are at the discovery stage with a long path to evaluation and clinical implementation. The ultimate challenge will be optimisation of prevention strategies that can be implemented in children identified as being at risk of an NCD through the use of biomarkers.3

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Exhaled Biomarkers and Gene Expression at Preschool Age Improve Asthma Prediction at 6 Years of Age

Abstract: Adding information on exhaled VOCs and possibly expression of inflammation genes to the API significantly improves an accurate asthma diagnosis in preschool children. Clinical trial registered with www.clinicaltrial.gov (NCT 00422747).

Cited by 74 publications

References 44 publications

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

Asthma in childhood

Immune biomarkers in the spectrum of childhood noncommunicable diseases

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