Exfoliatio areata linguae et mucosae oris: Eine Schleimhautmanifestation der Psoriasis pustulosa?

Casper, Ulrike; Seiffert, Kristina; Dippel, Edgar; Zouboulis, Christos C.

doi:10.1007/s001050050837

Cited by 21 publications

(15 citation statements)

References 6 publications

(4 reference statements)

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“…Two patients presented with concurrent pustular psoriasis and mucosal lesions with the characteristic picture of geographic tongue. There was parallel improvement of the skin and the mucosal lesions with systemic retinoid treatment [177].…”

Section: Geographic Tonguementioning

confidence: 88%

Off-label uses of retinoids in dermatology

Li¹,

Liu²,

Luo³

et al. 2012

Our Dermatol Online

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Section: Geographic Tonguementioning

confidence: 88%

Off-label uses of retinoids in dermatology

Li¹,

Liu²,

Luo³

et al. 2012

Our Dermatol Online

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“…Les autres traitements utilisés et proposés dans la littéra-ture dans l'indication des langues géographiques algiques sont les corticoïdes locaux [9,1], les rétinoïdes locaux [10,1], les rétinoïdes par voie orale [11,1] et la ciclosporine per os [12,1]. Ces deux derniers traitements, bien qu'efficaces, sont disproportionnés en raison des effets indésirables potentiels.…”

Section: Discussionunclassified

Étude rétrospective de l’efficacité du Protopic® (tacrolimus) dans le traitement de la langue géographique algique

Haddad¹,

Boralévi

Catros³

et al. 2015

Med Buccale Chir Buccale

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Résumé -Introduction :La langue géographique (LG) est le plus souvent asymptomatique. Quand elle est douloureuse, le traitement est mal codifié. L'objectif de cette étude est d'évaluer l'efficacité du tacrolimus topique appliqué sur les LG algiques. Matériels et méthodes : Il s'agit d'une étude de cohorte descriptive, rétrospective, menée dans le service d'odontologie du CHU de Bordeaux de janvier 2012 à novembre 2013. Les patients sont traités par tacrolimus 0,1 % en application locale 2 fois par jour pendant 1 mois. Le critère de jugement principal est une évaluation de la douleur avec une échelle numérique verbale (ENV) de 0 à 10 à J0 et à 1 mois. Résultats : Trente et un patients ont consulté pour une langue géographique (LG). Sur ces 31 patients, 17 avaient des brûlures de la langue. Sur ces 17, 12 avaient une douleur imputable à la LG. Sur ces 12, 10 ont été traités par tacrolimus. Lors de la consultation initiale, l'ENV était de 5,9 +/-1,87. L'évaluation à un mois a montré une amélioration significative de l'ENV, 1,6 +/-1,5 (p < 0,001). Aucun événement indésirable grave n'est rapporté, seule une douleur oesophagienne est mentionnée chez trois patients. Conclusion : L'utilisation du tacrolimus topique semble efficace et bien tolérée dans l'indication d'une LG algique. Cependant, un essai randomisé versus placebo serait nécessaire afin de pouvoir conclure avec certitude. Abstract -Introduction:Geographic tongue is usually an asymptomatic disorder. There is no symptomatic treatment evaluated with clinical trials. Our objective was to evaluate the efficiency of tacrolimus in painful Geographic Tongue (GT). Methods: A retrospective descriptive cohort study was performed in the Department of Odontology PQR at the CHU in Bordeaux from January 2012 to November 2013. Patients with painful GT were treated with 0.1% tacrolimus (Protopic) topically twice a day for one month. The primary endpoint was the evaluation of pain with a numerical pain scale (NPS) from 0 to 10 the first day and one month later. The secondary endpoints were the improvement of the quality of life and of eating . Results: Thirty-one patients with GT consulted during the period studied. Seventeen had a burned tongue sensation, five patients presented primitive glossodynia and twelve had painful GT. Ten patients were treated with tacrolimus topically. The average value of the NPS was 5,9 (+/-1.87) at the first consultation. The GT lesions were present in all cases. Eating difficulties or a burned tongue sensation were described by patients. The evaluation one month after the prescription of Protopic showed a significant improvement of the NPS, with an average of 1,6 (+/-1.5) (t-test, p<0.001%). An improvement of the quality of life was noted for all patients. No serious adverse events were reported except esophagus pain for three patients. Conclusions: The utilization of topical tacrolimus seems to be efficient and well-tolerated in painful GT. However, randomized trials versus placebo are necessary to conclude with certitude.

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“…The first one includes authentic psoriatic lesions confirmed by biopsy and with a parallel clinical course with skin lesions. The second group comprises a majority of oral findings in psoriasis and includes nonspecific lesions such as fissured tongue (FT) or geographic tongue (GT) .…”

Section: Introductionmentioning

confidence: 95%

“…In fact, oral lesions are more often detected in patients affected by psoriasis in comparison with control groups . Psoriatic oral lesions can be divided into two groups.…”

Section: Introductionmentioning

confidence: 99%

Fissured tongue responding to biologics during the treatment of psoriasis: the importance of detecting oral involvement of psoriasis

2013

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Recent studies have provided more evidence that psoriasis can give mucosal lesions, especially oral. Nonspecific lesions such as fissured tongue and geographic tongue are relatively frequent in patients suffering from psoriasis. We report a case of a patient presenting an important improvement of his fissured tongue paralleling the improvement of the cutaneous lesions after a 5-month systemic therapy with infliximab. The authors think it would be important to consider possible oral lesions in patients suffering from psoriasis in normal practice and to evaluate them introducing specific clinical scales.

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Exfoliatio areata linguae et mucosae oris: Eine Schleimhautmanifestation der Psoriasis pustulosa?

Cited by 21 publications

References 6 publications

Off-label uses of retinoids in dermatology

Off-label uses of retinoids in dermatology

Étude rétrospective de l’efficacité du Protopic® (tacrolimus) dans le traitement de la langue géographique algique

Fissured tongue responding to biologics during the treatment of psoriasis: the importance of detecting oral involvement of psoriasis

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