Exertional Rhabdomyolysis and Acute Renal Failure Following the Army Physical Fitness Test

Tietjen, David P.; Guzzi, Louis M.

doi:10.1093/milmed/154.1.23

Cited by 27 publications

(11 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 25,000 cases of exercise-associated rhabdomyolysis are reported annually in the USA (Sauret et al, 2002), most of them among military recruits and long-distance runners (Kao et al, 1998; Kuipers, 1994; Nielsen and Mazzone, 1999; Schiff et al, 1978; Tietjen and Guzzi, 1989), and only a few among swimmers (Galvez et al, 2008; Stella and Shariff, 2012). Eccentric contractions produced by muscle tension in activities like downhill running and jumping are more likely to cause muscle damage than concentric contractions.…”

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of the IL-6 -174C Genetic Polymorphism in Long Distance Swimmers

Ben‐Zaken

Meckel

Nemet

et al. 2017

Journal of Human Kinetics

View full text Add to dashboard Cite

The IL-6 -174G/C single nucleotide polymorphism (SNP) functionally affects IL-6 activity, with the G-allele associated with increased IL-6 levels. The C-allele was found to be associated with exercise-induced skeletal muscle damage. The aim of the present study was to examine the association between the IL-6 -174G/C polymorphism and athletic performance among elite swimmers and runners. The study sample included 180 track and field athletes and 80 swimmers. Track and field athletes were assigned to three sub-groups: long-distance runners, middle-distance runners and short-distance runners. Swimmers were assigned to two subgroups: long-distance swimmers and short-distance swimmers. The control group consisted of 123 non-athletic healthy individuals. Genomic DNA was extracted from peripheral blood following a standard protocol. Genotyping was performed using polymerase chain reaction (PCR). The CC genotype and C-allele frequency were significantly higher in the long-distance swimmers (18 and 43%, respectively) compared to the long-distance runners (3 and 14%, respectively, p < 0.001); middle-distance runners (4 and 22%, respectively, p < 0.001); and controls (5 and 19%, respectively, p < 0.001). In addition, the CC genotype and C-allele frequency were significantly higher (p < 0.001) in long-distance swimmers compared to short-distance swimmers (18 versus 5% and 43 versus 29% for the CC genotype and C-allele frequency, respectively). The higher frequency of the C-allele and CC genotype among long-distance swimmers suggests that the rarity of exercise-associated rhabdomyolysis among swimmers is probably related to other sports-specific or water-related protective mechanisms. It is possible that swimming selection in talented endurance athletes who are C-allele carriers represents an example of genetically-dependent sports selection.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Prevalence of the IL-6 -174C Genetic Polymorphism in Long Distance Swimmers

Ben‐Zaken

Meckel

Nemet

et al. 2017

Journal of Human Kinetics

View full text Add to dashboard Cite

show abstract

“…In contrast to high-voltage injuries, rhabdomyolysis is rare in lightning injuries. Rhabdomyolysis, with or without compartment syndrome, can occur after prolonged surgical procedures, such as bariatric surgery [9,[16][17][18][19][20][21][22][23].…”

Section: Traumamentioning

confidence: 99%

“…There are many reported cases of exercise-induced rhabdomyolysis not related to genetic abnormalities, with most being reported among athletes, military recruits and runners [20,[23][24][25][26][27]. Several factors predispose to exercise-induced rhabdomyolysis, such as high humidity, anticholinergic medications, hypokalemia and performance-enhancing drugs.…”

Section: Exercisementioning

confidence: 99%

Rhabdomyolysis: a review, with emphasis on the pediatric population

2010

View full text Add to dashboard Cite

Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA. It can result from a wide variety of disorders, such as trauma, exercise, medications and infection, but in the pediatric population, infection and inherited disorders are the most common causes of rhabdomyolysis. Approximately half of patients with rhabdomyolysis present with the triad of myalgias, weakness and dark urine. The clinical suspicion, especially in the setting of trauma or drugs, is supported by elevated creatinine kinase levels and confirmed by the measurement of myoglobin levels in serum or urine. Muscle biopsy and genetic testing should be performed if rhabdomyolysis is recurrent or metabolic myopathy is suspected. Early recognition is important to prevent AKI through the use of aggressive hydration. Prevention is important in patients with inherited forms, but novel therapies may be developed with the better understanding of the pathophysiology and genetics of rhabdomyolysis.

show abstract

“…These facts lend support to the theor y that physically deconditioned individuals are at greater risk of developing AER following an isolated bout of very strenuous exercise. 3,5,15,17,20,22 It is also possible for normal, healthy individuals who may be ''physically fit'' overall to be at risk of developing AER when performing exercises for which they have not been conditioned. 3,12 Identification of this patient's medical condition by a physical therapist ensured early recognition as well as immediate and appropriate medical management to prevent serious complications (acute renal failure, disseminated intravascular coagulation, or compartment syndrome).…”

mentioning

confidence: 99%