Exertional heat stroke causes long-term skeletal muscle epigenetic reprogramming, altered gene expression, and impaired satellite cell function in mice
Kevin O. Murray,
Jason O. Brant,
Ray A. Spradlin
et al.
Abstract:The effect of exertional heat stroke (EHS) exposure on skeletal muscles is incompletely understood. Muscle weakness is an early symptom of EHS but is not considered a major target of multiorgan injury. Previously, in a preclinical mouse model of EHS, we observed vulnerability of limb muscles to a second EHS exposure, suggesting hidden processes contributing to declines in muscle resilience. Here, we evaluated possible molecular origins of EHS-induced declines in muscle resilience. Female C57BL/6 mice [total n … Show more
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