Exercised-induced increase in lipid peroxidation parameters in amenorrhelc female athletes

Ayres, Stacey A.; Baer, Janine T.; Subbiah, M.T.R.

doi:10.1016/s0015-0282(97)00428-7

Cited by 40 publications

(35 citation statements)

References 32 publications

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“…Studies in animals support the theory that estrogen protects membrane integrity during times of oxidative stress. Antioxidants act as a cooperative network, employing a series of redox reactions [17][18][19][20]. Additive effect of AsA in anti-oxidation may be responsible for increased levels of tissue estrogen.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ascorbic Acid on the Estrogen/Progesteron Levels in the Isolated Rabbit Uterine Muscle

Bostancı¹

2012

J Clin Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

The Effects of Ascorbic Acid on the Estrogen/Progesteron Levels in the Isolated Rabbit Uterine Muscle

Bostancı¹

2012

J Clin Gynecol Obstet

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“…(f) There is a recently confirmed finding that a history of preeclampsia/pregnancy -induced hypertension is associated with a reduced risk of breast cancer (62); although other mechanisms have been suggested to explain this association, such as reduced levels of estrogens and insulin-like growth factor-I (62), the statistically significant higher lipid peroxidation levels found in women suffering from this condition with respect to those associated with a normal pregnancy (63-66) may be responsible, at least in part, for this protection. (g) Physical activity is associated with a decreased risk of breast cancer and has been consistently shown to increase lipid peroxidation in human and animal studies (67)(68)(69)(70). (h) Alcoholic beverages have been consistently shown to increase breast cancer risk and have been found to inhibit lipid peroxidation in several studies (71)(72)(73)(74)(75).…”

Section: Epidemiology Of Breast Cancer: Role Of Lipid Peroxidationmentioning

confidence: 99%

“…Physical exercise has been consistently shown to reduce the risk of breast cancer (143)(144)(145), and it is also a potent inducer of lipid peroxidation (67)(68)(69)(70). Multiple studies have shown markers of lipid peroxidation to be elevated in ultramarathon runners, mountain climbers, and various groups of trained and untrained humans and animals following physical activity (69,70,146).…”

Section: Epidemiology Of Breast Cancer: Role Of Lipid Peroxidationmentioning

confidence: 99%

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

Gago‐Dominguez

Castelao

Pike

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We have recently proposed a common mechanistic pathway by which obesity and hypertension lead to increased renal cell cancer risk. Our hypothesis posits lipid peroxidation, which is a principal mechanism in rodent renal carcinogenesis, as an intermediate step that leads to a final common pathway shared by numerous observed risks (including obesity, hypertension, smoking, oophorectomy/hysterectomy, parity, preeclampsia, diabetes, and analgesics) or protective factors (including oral contraceptive use and alcohol) for renal cell cancer [Cancer Causes Control 2002;13:287 -93]. During this exercise, we have noticed how certain risk factors for renal cell carcinoma are protective for breast cancer and how certain protective factors for renal cell carcinoma increase risk for breast cancer. Parity and oophorectomy, for example, are positively associated with renal cell carcinoma but are negatively associated with breast cancer. Similarly, obesity and hypertension are positively associated with renal cell carcinoma, but obesity is negatively associated with breast cancer in premenopausal women and hypertension during pregnancy is negatively associated with breast cancer. Furthermore, alcohol intake, negatively associated with renal cell carcinoma, is also positively associated with breast cancer. We propose here the possibility that lipid peroxidation may represent a protective mechanism in breast cancer. Although this runs counter to the conventional view that lipid peroxidation is a process that is harmful and carcinogenic, we present here the chemical and biological rationale, based on epidemiologic and biochemical data, which may deserve further consideration and investigation. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2829 -39)

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“…In AM athletes, recent data identifies impaired endothelial function [11], elevated lowdensity and high-density lipoprotein levels [20], reduced metabolites of nitric oxide, (nitrates and nitrites) [21], and increased susceptibility to lipid peroxidation [22] as potential cardiovascular consequences, presumably due to the hypoestrogenism. Although the clinical significance of these consequences remains undetermined, these findings are suggestive of a potentially increased risk of premature cardiovascular disease (CVD).…”

Section: Introductionmentioning

confidence: 99%

The Cardiovascular Effects of Chronic Hypoestrogenism in Amenorrhoeic Athletes

O’Donnell

Souza

2004

Sports Medicine

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In premenopausal women, the most severe menstrual dysfunction is amenorrhea and is associated with chronic hypoestrogenism. In postmenopausal women, the coincident hypoestrogenism observed is associated with a number of clinical sequelae related to cardiovascular health. Due to an observed cardioprotective effect of E2, persistently low E2 levels in amenorrheic (AM) athletes may confer deleterious effects on cardiovascular health.The incidence of amenorrhea among athletes is much greater than that observed among sedentary women. Recent data in AM athletes demonstrate impaired endothelial function, elevated low-and high-density lipoprotein levels, reduced circulating nitrates and nitrites, and increased susceptibility to lipid peroxidation. An improvement in endothelial function has also been reported during the recovery of menstrual cyclicity in a small sample of previously AM athletes. Although no longitudinal studies exist, these findings are suggestive of increased risk of premature cardiovascular disease in AM athletes. These issues are explored and discussed in detail in this comprehensive review paper. Future research should focus on the presentation and progression of these adverse cardiovascular parameters in physically active women and athletes with hypoestrogenism to determine their effect on long-term health outcomes.

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Exercised-induced increase in lipid peroxidation parameters in amenorrhelc female athletes

Cited by 40 publications

References 32 publications

The Effects of Ascorbic Acid on the Estrogen/Progesteron Levels in the Isolated Rabbit Uterine Muscle

The Effects of Ascorbic Acid on the Estrogen/Progesteron Levels in the Isolated Rabbit Uterine Muscle

Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast Cancer

The Cardiovascular Effects of Chronic Hypoestrogenism in Amenorrhoeic Athletes

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