Exercise with blood flow restriction as a new tool for health improvement in hypertensive elderly women: the role of purinergic enzymes

Effects of physical exercise on the functionality of human nucleotidases: A systematic review

“…After full‐text analysis, five articles were excluded; four did not address the outcome of interest and the other was an expanded abstract. After full‐text evaluation, 13 studies were included in this review (Coppola et al, 2005 ; da Silveira et al, 2018 ; Dorneles et al, 2019 ; Karabulut et al, 2011 ; Kirby et al, 2012 ; Lammers et al, 2020 ; Mânica et al, 2020 ; Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, dos Santos, et al, 2016 ; Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, Farinha, et al, 2016 ; Miron et al, 2019 ; Moritz et al, 2017 ; Moritz et al, 2021 ; Yegutkin et al, 2007 ) (Figure 1 ).…”

“…The main characteristics of the included studies are shown in Table 1 . Among the 13 included studies, eight (61.53%) (Coppola et al, 2005 ; Dorneles et al, 2019 ; Karabulut et al, 2011 ; Kirby et al, 2012 ; Miron et al, 2019 ; Moritz et al, 2017 ; Moritz et al, 2021 ; Yegutkin et al, 2007 ) exclusively studied healthy individuals and five (38.47%) (da Silveira et al, 2018 ; Lammers et al, 2020 ; Mânica et al, 2020 ; Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, dos Santos, et al, 2016 ; Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, Farinha, et al, 2016 ) reported on individuals with a disease. With the regard to the studies with healthy individuals, two studies (15.38%) (Karabulut et al, 2011 ; Moritz et al, 2017 ) included healthy and sedentary subjects, one (7.7%) (Kirby et al, 2012 ) included healthy young and older adults, one (7.7%) (Miron et al, 2019 ) included semi‐professional athletes and four (30.76%) (Coppola et al, 2005 ; Dorneles et al, 2019 ; Moritz et al, 2021 ; Yegutkin et al, 2007 ) studies included healthy sedentary and trained/physically active subjects.…”

“…With the regard to the studies with healthy individuals, two studies (15.38%) (Karabulut et al, 2011 ; Moritz et al, 2017 ) included healthy and sedentary subjects, one (7.7%) (Kirby et al, 2012 ) included healthy young and older adults, one (7.7%) (Miron et al, 2019 ) included semi‐professional athletes and four (30.76%) (Coppola et al, 2005 ; Dorneles et al, 2019 ; Moritz et al, 2021 ; Yegutkin et al, 2007 ) studies included healthy sedentary and trained/physically active subjects. With respect to studies that included unhealthy individuals, two studies (15.38%) (Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, dos Santos, et al, 2016 ; Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, Farinha, et al, 2016 ) included metabolic syndrome patients and healthy individuals, one (7.7%) (da Silveira et al, 2018 ) included chronic kidney disease patients and two (15.38%) (Lammers et al, 2020 ; Mânica et al, 2020 ) included hypertensive patients. A total of 447 subjects were included in this systematic review, 274 (61.30%) male and 173 (38.70%) female subjects, with a mean age of 39.05 years (variation 20.56–67.2 years).…”

“…With respect to studies that included unhealthy individuals, two studies (15.38%) (Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, dos Santos, et al, 2016;Martins, Bagatini, Cardoso, Zanini, Abdalla, Baldissarelli, Dalenogare, Farinha, et al, 2016) included metabolic syndrome patients and healthy individuals, one (7.7%) (da Silveira et al, 2018) included chronic kidney disease patients and two (15.38%) (Lammers et al, 2020;Mânica et al, 2020) included hypertensive patients. A total of 447 subjects were included in this systematic review, 274 (61.30%) male and 173 (38.70%) female subjects, with a mean age of 39.05 years (variation 20.56-67.2 years).…”

“…Additional limitations are present in our study and should be pointed out: (1) only one randomized clinical trial (Mânica et al, 2020) was found in our search; (2) there wre methodological differences in the exercise protocols used in selected studies (since there are a limited number of published studies on this research subject, it was impossible to restrict the exercise method or type);…”