Exercise Training Reduces Sympathetic Modulation on Cardiovascular System and Cardiac Oxidative Stress in Spontaneously Hypertensive Rats

Bertagnolli, Mariane; Schenkel, Paulo Cavalheiro; Carraro, Cristina Campos; Mostarda, Cristiano Teixeira; Casarini, Dulce Elena; Belló‐Klein, Adriane; Irigoyen, Maria Cláudia; Rigatto, Katya

doi:10.1038/ajh.2008.270

Cited by 77 publications

(55 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is known that regular exercise improves glycemia, lipid profile (8), and insulin sensitivity, promotes weight reduction, and improves muscle glucose uptake. In diabetic and hypertensive rats, physical training has been important in the treatment of metabolic and autonomic disorder by contributing to the improvement in HRV, baroreflex sensitivity, vagal modulation, and blood pressure (4,25,28). Additionally, exercise training can influence metabolic, hemodynamic, and autonomic control even in healthy individuals (12,19).…”

Section: Discussionmentioning

confidence: 99%

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

Moraes‐Silva

Mostarda

Moreira

et al. 2013

Journal of Applied Physiology

View full text Add to dashboard Cite

Moraes-Silva IC, Mostarda C, Moreira ED, Silva KAS, dos Santos F, de Angelis K, Farah VMA V, Irigoyen MC. Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development. J Appl Physiol 114: 786 -791, 2013. First published January 17, 2013 doi:10.1152/japplphysiol.00586.2012.-High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 wk. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index and glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured, whereas heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations compared with all the other groups in insulin resistance (in mg·dl Ϫ1 ·min Ϫ1 : F: 3.4 Ϯ 0.2; C: 4.7 Ϯ 0.2; CT: 5.0 Ϯ 0.5 FT: 4.6 Ϯ 0.4), mean BP (in mmHG: F: 117 Ϯ 2; C: 100 Ϯ 2; CT: 98 Ϯ 2; FT: 105 Ϯ 2), and Lee index (in g/mm: F ϭ 0.31 Ϯ 0.001; C ϭ 0.29 Ϯ 0.001; CT ϭ 0.27 Ϯ 0.002; FT ϭ 0.28 Ϯ 0.002), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an ϳ50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well as in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption.fructose; exercise training; autonomic nervous system SEVERAL STUDIES HAVE SHOWN that poor eating habits and a large increase in fructose consumption in recent years has contributed to the epidemic of metabolic syndrome (2, 5). These unhealthy habits may result in physiological changes that contribute to a higher morbidity and mortality in humans (14). Among these changes, increase of blood pressure, plasma lipids, obesity, glucose intolerance, insulin resistance, and hyperinsulinemia are the most evident. Additionally, studies have shown an association between these factors as hyperinsulinemia and hypertension, in both humans and animals (10, 21, 36), indicating that once these alterations are present, the higher is the incidence of cardiovascular diseases.Autonomic nervous system dysfunction also accompanies these metabolic disturbances. Our research group has ...

show abstract

Section: Discussionmentioning

confidence: 99%

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

Moraes‐Silva

Mostarda

Moreira

et al. 2013

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…KT prigušuje srčanu simpatič-ku modulaciju i srčanu hipertrofi ju, koja je povezana sa smanjenjem oksidativnog stresa i povećanjem bioraspoloživosti dušikova oksida (NO) (Bertagnolli et al, 2008). U studiji utjecaja KT na krvne lipide, krvni tlak i funkciju dimenzije šupljine lijeve klijetke, između nogometaša i nesportaša, razina sistoličkog krvnog tlaka kod nogometaša bila je znatno niži od kontrolne skupine (p < ,05 ), dok su sistolički (LVSP) i dijastolički (LVDP) promjeri lijevog ventrikula nogometaša bili značajno viši naspram kontrolne skupine (Gokhan et al, 2013).…”

Section: Tonći Grgurinović Et Al: Differences In Health Indicators unclassified

“…ET attenuates cardiac sympathetic modulation and cardiac hypertrophy, which were associated with reduced oxidative stress and increased nitric oxide (NO) bioavailability (Bertagnolli et al, 2008). In the study of the effects of ET on blood lipids, blood pressure and left ventricular cavity dimensions function between football players and non-athletes, mean systolic blood pressure levels of football players were signifi cantly lower than control group (p<.05).…”

Section: Tonći Grgurinović Et Al: Differences In Health Indicators mentioning

confidence: 99%

Razlike u zdravstvenim pokazateljima kod nogometaša mlađih i starijih od 30 godina / Differences in health indicators in football players younger and older than 30 years

Grgurinović¹,

Sindik

2016

SIZ

View full text Add to dashboard Cite

Numerous studies show that wide range of anthropological characteristics and health indicators significantly affects the success in football. Therefore, constant monitoring of these indicators provides to the coaches the information useful for the planning of the training process, adjusted to concrete athletes. This study explores selected morphological, physiological characteristics and health (MPH) indicators of adult football players of various levels of sporting excellence. The aim of the study was to determine the differences in MPH indicators, as well as their correlation, stratified according to the age group of the athletes. The different profiles of players were identified, in relation to selected MPH indicators. A sample of 813 male players is examined, 362 in the age group 17-30 years (M±SD 21.48±3.51) and 451 aged over 30 years (43.84±9.17), from Zagreb football clubs, included in medical examination at the Clinic for Occupational Health and Sport. Several differences in MPH are found between two age groups, mainly in direction more desirable features in younger age group. The results provide important information for planning training, but also for health prevention measures.

show abstract

“…This mechanism includes the sympathetic and/or parasympathetic activation that changes Heart Rate (HR) to promote BP stabilization 17 . Heart Rate Variability (HRV) has been studied for the last few decades 18 to assess the autonomic modulation of the cardiovascular system 19,20 . Good BP adaptation is an indication of high HRV, whereas lower HRV is frequently an indicator of abnormal and/or insufficient adaptation of cardiac Autonomic Nervous System (ANS) modulation 21 .…”

Section: Introductionmentioning

confidence: 99%

A single dose of dark chocolate increases parasympathetic modulation and heart rate variability in healthy subjects

Duarte

Mostarda

Irigoyen³

et al. 2016

Rev. Nutr.

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the acute effect of a single dose of dark chocolate (70% cocoa) on blood pressure and heart rate variability. Methods: Thirty-one healthy subjects (aged 18-25 years; both sexes) were divided into two groups: 10 subjects in the white chocolate (7.4 g) group and 21 in the dark chocolate (10 g) group; measurements were performed at the university's physiology lab. An electrocardiogram measured the sympathovagal balance by spectral and symbolic analysis. Results: A single dose of dark chocolate significantly reduced systolic blood pressure and heart rate. After consuming 10 g of dark chocolate, significant increases were observed for heart rate variability, standard deviation of RR intervals standard deviation of all NN intervals, square root of the mean squared differences between adjacent normal RR intervals root mean square of successive differences, and an increase in the high frequency component in absolute values, representing the parasympathetic modulation. Conclusion: In conclusion the importance of our results lies in the magnitude of the response provoked by a single dose of cocoa. Just 10 g of cocoa triggered a significant increase in parasympathetic modulation and heart rate variability. These combined effects can potentially increase life expectancy because a reduction in heart rate variability is associated with several cardiovascular diseases and higher mortality.

show abstract

Exercise Training Reduces Sympathetic Modulation on Cardiovascular System and Cardiac Oxidative Stress in Spontaneously Hypertensive Rats

Abstract: ET attenuates cardiac sympathetic modulation and cardiac hypertrophy, which were associated with reduced oxidative stress and increased nitric oxide (NO) bioavailability.

Cited by 77 publications

References 36 publications

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development

Razlike u zdravstvenim pokazateljima kod nogometaša mlađih i starijih od 30 godina / Differences in health indicators in football players younger and older than 30 years

A single dose of dark chocolate increases parasympathetic modulation and heart rate variability in healthy subjects

Contact Info

Product

Resources

About