Exercise training prevents the attenuation of anesthetic pre‐conditioning‐mediated cardioprotection in diet‐induced obese rats

Li, L.; Meng, Fanqing; Li, N.; Zhang, L.; Wang, J.; Wang, H.; Li, D.; Zhang, X.; Dong, Ping; Chen, Y.

doi:10.1111/aas.12414

Cited by 11 publications

(8 citation statements)

References 37 publications

(53 reference statements)

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“…63 Studies have assessed if exercise training restores the attenuated efficacy of classic preconditioning associated with obesity. Regular exercise training in obese rats 64 or obese mice 65 can (partly) restore the attenuated efficacy of Thijssen et al…”

Section: Do Risk Factors For Cvd Impair Exercise Preconditioning?mentioning

confidence: 99%

“…These effects of exercise were related to upregulation of pro-survival signalling pathways, increase in kinase phosphorylation, decreased levels of phosphates and increased resistance of mitochondrial permeability transition pore-opening. [64][65][66] Since no impact of 4-week exercise training was found on glucose, cholesterol, insulin, fat mass or body mass, 66 restoration of preconditioning occur independent of changes in traditional CVD risk factors. Although more work is required, these preliminary studies highlight the ability of exercise training (in obese animals) to restore attenuated cardioprotection afforded by classic ischaemic preconditioning.…”

Section: Exercise Preconditioning To Protect the Heart 2017mentioning

confidence: 99%

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Association of Exercise Preconditioning With Immediate Cardioprotection

et al. 2018

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Section: Do Risk Factors For Cvd Impair Exercise Preconditioning?mentioning

confidence: 99%

Section: Exercise Preconditioning To Protect the Heart 2017mentioning

confidence: 99%

Association of Exercise Preconditioning With Immediate Cardioprotection

et al. 2018

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“…() have demonstrated that exercise training partially restores, while tandem training and caloric limitation completely preserves ischaemic preconditioning in aged rats (Abete et al ., ). Exercise has also been shown to restore cardioprotective signalling and preconditioning in obese mice, independently of associated co‐morbidities (Pons et al ., ; Li et al ., ). Whether these exercise effects involve sarcolemmal modulation is presently unclear.…”

Section: Strategic Manipulation Of Membrane‐dependent Protectionmentioning

confidence: 97%

Sarcolemmal dependence of cardiac protection and stress‐resistance: roles in aged or diseased hearts

Hoe

May

Headrick

et al. 2016

British J Pharmacology

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Disruption of the sarcolemmal membrane is a defining feature of oncotic death in cardiac ischaemia-reperfusion (I-R), and its molecular makeup not only fundamentally governs this process but also affects multiple determinants of both myocardial I-R injury and responsiveness to cardioprotective stimuli. Beyond the influences of membrane lipids on the cytoprotective (and death) receptors intimately embedded within this bilayer, myocardial ionic homeostasis, substrate metabolism, intercellular communication and electrical conduction are all sensitive to sarcolemmal makeup, and critical to outcomes from I-R. As will be outlined in this review, these crucial sarcolemmal dependencies may underlie not only the negative effects of age and common co-morbidities on myocardial ischaemic tolerance but also the on-going challenge of implementing efficacious cardioprotection in patients suffering accidental or surgically induced I-R. We review evidence for the involvement of sarcolemmal makeup changes in the impairment of stress-resistance and cardioprotection observed with ageing and highly prevalent co-morbid conditions including diabetes and hypercholesterolaemia. A greater understanding of membrane changes with age/disease, and the inter-dependences of ischaemic tolerance and cardioprotection on sarcolemmal makeup, can facilitate the development of strategies to preserve membrane integrity and cell viability, and advance the challenging goal of implementing efficacious 'cardioprotection' in clinically relevant patient cohorts. Linked Articles This article is part of a themed section on Molecular Pharmacology of G Protein-Coupled Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.20/issuetoc.

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“…Interestingly, exercise therapy preserves the preconditioning effect of both ischemia and anesthetic administration in senescent and obese animals. 113,122 The relationship between exercise training and preconditioning has led investigators to seek out shared mechanisms of organ protection. For instance - NOS expression and ROS are known to play prominent roles in PC.…”

Section: Therapeutic Applications Targeting Subcellular Energeticsmentioning

confidence: 99%

Subcellular Energetics and Metabolism: Potential Therapeutic Applications

Thiele

2017

Anesthesia &Amp; Analgesia

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Part I of this review discussed the similarities between embryogenesis, mammalian adaptions to hypoxia (primarily driven by Hypoxia Inducible Factor-1 [HIF-1]), ischemia-reperfusion injury (and its relationship with reactive oxygen species), hibernation, diving animals, cancer, and sepsis, and focused on the common characteristics that allow cells and organisms to survive in these states. Part II of this review describes techniques by which researchers gain insight into subcellular energetics and identify potential future tools for clinicians. In particular, P31 nuclear magnetic resonance to measure high energy phosphates, serum lactate measurements, the use of near infrared spectroscopy to measure the oxidation state of cytochrome aa3, and the ability of the protoporphyrin IX-triplet state lifetime technique to measure mitochondrial oxygen tension are discussed. Additionally, this review will discuss novel treatment strategies such as hyperbaric oxygen, preconditioning, exercise training, therapeutic gases, as well as inhibitors of HIF-1, HIF prolyl hydroxylase (PHD), and Peroxisome proliferator-activated receptors (PPARs).

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Exercise training prevents the attenuation of anesthetic pre‐conditioning‐mediated cardioprotection in diet‐induced obese rats

Cited by 11 publications

References 37 publications

Association of Exercise Preconditioning With Immediate Cardioprotection

Association of Exercise Preconditioning With Immediate Cardioprotection

Sarcolemmal dependence of cardiac protection and stress‐resistance: roles in aged or diseased hearts

Subcellular Energetics and Metabolism: Potential Therapeutic Applications

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