Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia

Motiani, Kumail K.; Collado, M. C.; Eskelinen, Jari-Joonas; Virtanen, Kirsi A.; Löyttyniemi, Eliisa; Salminen, Seppo; Nuutila, Pirjo; Kalliokoski, Kari K.; Hannukainen, Jarna C.

doi:10.1249/mss.0000000000002112

Cited by 196 publications

(245 citation statements)

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“…Frequent treatment with antibiotics and/or a regular intake of non-antibiotic drugs have negative effects on the gut microbiota 33–35. Regular exercise and consuming a sport-specific diet are known to be associated with a favourable gut microbiota 36–38. Furthermore, the superdonor should not be a first-degree relative of any of the patients in a trial since the intestinal microbiota is affected by the genetic composition, and a superdonor and recipient with greater genetic similarity may also have greater similarities in their faecal microbiota 39 40.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

El‐Salhy

Hatlebakk

Gilja

et al. 2019

Gut

346

563

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ObjectiveFaecal microbiota transplantation (FMT) from healthy donors to patients with irritable bowel syndrome (IBS) has been attempted in two previous double-blind, placebo-controlled studies. While one of those studies found improvement of the IBS symptoms, the other found no effect. The present study was conducted to clarify these contradictory findings.DesignThis randomised, double-blind, placebo-controlled study randomised 165 patients with IBS to placebo (own faeces), 30 g FMT or 60 g FMT at a ratio of 1:1:1. The material for FMT was obtained from one healthy, well-characterised donor, frozen and administered via gastroscope. The primary outcome was a reduction in the IBS symptoms at 3 months after FMT (response). A response was defined as a decrease of 50 or more points in the total IBS symptom score. The secondary outcome was a reduction in the dysbiosis index (DI) and a change in the intestinal bacterial profile, analysed by 16S rRNA gene sequencing, at 1 month following FMT.ResultsResponses occurred in 23.6%, 76.9% (p<0.0001) and 89.1% (p<00.0001) of the patients who received placebo, 30 g FMT and 60 g FMT, respectively. These were accompanied by significant improvements in fatigue and the quality of life in patients who received FMT. The intestinal bacterial profiles changed also significantly in the groups received FMT. The FMT adverse events were mild self-limiting gastrointestinal symptoms.ConclusionsFMT is an effective treatment for patients with IBS. Utilising a well-defined donor with a normal DI and favourable specific microbial signature is essential for successful FMT. The response to FMT increases with the dose.Trial registrationwww.clinicaltrials.gov (NCT03822299) and www.cristin.no (ID657402).

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Section: Discussionmentioning

confidence: 99%

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

El‐Salhy

Hatlebakk

Gilja

et al. 2019

Gut

346

563

View full text Add to dashboard Cite

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“…There might be numerous changes responsible for the improved metabolic phenotypes in both dams and offspring after maternal exercise. Given the pivotal role of gut microbiota plays in metabolic health and the confirmed link of exercise with the intestinal microbial community (Liu et al, 2020;Motiani et al, 2020), we discussed the potential contributions of gut microbiota to the intergenerational benefits of maternal exercise. Our data demonstrated that maternal exercise significantly modified gut microbiota in dams fed HFD at weaning, including both structure and composition, which was inconsistent with the results of another recent study.…”

Section: Discussionmentioning

confidence: 99%

Maternal Exercise Improves High-Fat Diet-Induced Metabolic Abnormalities and Gut Microbiota Profiles in Mouse Dams and Offspring

Zhou

Xiao

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Red and blue represent significant association determined by ANCOM after FDR correction for multiple comparisons at a significant level adj.P < 0.05. levels in our study. In prediabetes or diabetic humans, Blautia abundance was found to be associated with better whole-body insulin sensitivity and lower glucose uptake in the colon 35 . Additionally, we identified Akkermansia as higher in mice having above-median plasma cholesterol but was not significantly related to plasma glucose.…”

Section: Discussionmentioning

confidence: 98%

Microbial modulation of host body composition and plasma metabolic profile

Huda

Winnike

Crowell

et al. 2020

Sci Rep

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The gut microbiota is a critical mediator of nutrition and disease risk. Like most complex traits, the microbiome is under genetic regulation and differs between inbred strains of mice. We tested the effect of fecal microbiota transplantation (FMT) on obesity, and plasma glucose. For this study, we collected microbiota from 2 inbred strains of mice which differ in adiposity and glucose tolerance, C57BL/6J and WSB/EiJ. C57BL/6J female mice (n = 18) were first treated with antibiotics for 4 weeks to ablate the microbiota. Following ablation, the mice were transplanted with microbiota from a C57BL/6J or a WSB/ EiJ mouse and clinical traits and plasma metabolomic profiles were interrogated at 2-and 4-weeks post-transplantation. Unexpectedly, the mice receiving WSB/EiJ microbiota increased adiposity but decreased plasma glucose. Metabolomic and 16S microbiota profiling indicated broad metabolic changes occurred during and after FMT. Detailed analysis of these interactions demonstrated specific microbiota-host metabolite interactions which may alter disease susceptibility.Bacteria is heavily colonized in the gastrointestinal tract, often referred to as the gut microbiota (hereafter referred to as microbiota), which can modulate nutritional status, health, and diseases of the host 1 . The diversity and composition of the gut bacteria have been intensely studied, as well as the microbiota's impact on the health status of the host 2 . The microbiota has been found to be associated with susceptibility to multiple diseases including: obesity 3 , cardiovascular diseases 4 , renal diseases 5 , and metabolic syndrome (MetSyn) 6 , all of which have impact on major public health. For example, 32% of American adults are obese 7 and nearly 35% have MetSyn 8 and the prevalence of these diseases are increasing. However, there are still critical gaps in our knowledge regarding how alterations of the microbiota (dysbiosis) can alter metabolism and thus disease susceptibility. A better understanding of the effect of host genetic-microbiota interactions on the composition of the microbiota and disease susceptibility is needed. A holistic view of the metabolic status of an individual, including both microbiota and host genetics, may provide new insights into the underlying mechanisms of pathobiology which may allow us to modulate disease onset, prognosis, and survival 9,10 .Metabolomic profiling may provide additional insight into the processes affected by specific bacteria or when the composition of the microbiota is altered 11 . It has been shown that the gut microbiota can have a significant effect on plasma metabolic profile, which can modulate host health 12 . Therefore, pairing metabolomics and microbiota analysis may yield important mechanistic insights. For example, trimethylamine N-oxide (TMAO) was identified as a risk factor for cardiovascular disease through a metaorganismal pathway involving the microbiota and diet 13 .Laboratory mice are often used to investigate both genetic and microbiota to understand the underlying mecha...

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Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia

Cited by 196 publications

References 50 publications

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

Maternal Exercise Improves High-Fat Diet-Induced Metabolic Abnormalities and Gut Microbiota Profiles in Mouse Dams and Offspring

Microbial modulation of host body composition and plasma metabolic profile

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