Exercise training modifies gut microbiota in normal and diabetic mice

Lambert, Jessica E.; Myslicki, Jason P.; Bomhof, Marc R.; Belke, Darrell D.; Shearer, Jane; Reimer, Raylene A.

doi:10.1139/apnm-2014-0452

Cited by 169 publications

(154 citation statements)

References 27 publications

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“…It remains to be determined what aspects of metabolic disease, such as obesity, hyperglycemia, or even specific dietary components interact with different modes of exercise to influence the microbiome. This seems worthwhile, since it has already been shown that 6 wk of exercise increased Bifidobacterium in the cecum of control mice but not in hyperglycemic leptin receptor-deficient (db/db) littermate mice (33).…”

Section: Discussionmentioning

confidence: 99%

“…The effect of exercise on the gut microbiota depends on the mode of exercise performed, such as volitional wheel running compared with forced treadmill training (1). A targeted assessment found that low-intensity exercise can influence the cecal microbiome in obese, hyperglycemic mice (33). However, a complicating factor of all of the above studies is that these types of exercise can lower body mass and/or prevent weight gain during obesity, which may not allow microbial changes to be ascribed to exercise vs. obesity or adiposity.…”

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confidence: 99%

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High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity

Denou

Marcinko

Surette

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

207

175

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Diet and exercise underpin the risk of obesity-related metabolic disease. Diet alters the gut microbiota, which contributes to aspects of metabolic disease during obesity. Repeated exercise provides metabolic benefits during obesity. We assessed whether exercise could oppose changes in the taxonomic and predicted metagenomic characteristics of the gut microbiota during diet-induced obesity. We hypothesized that high-intensity interval training (HIIT) would counteract high-fat diet (HFD)-induced changes in the microbiota without altering obesity in mice. Compared with chow-fed mice, an obesity-causing HFD decreased the Bacteroidetes-to-Firmicutes ratio and decreased the genetic capacity in the fecal microbiota for metabolic pathways such as the tricarboxylic acid (TCA) cycle. After HFD-induced obesity was established, a subset of mice were HIIT for 6 wk, which increased host aerobic capacity but did not alter body or adipose tissue mass. The effects of exercise training on the microbiota were gut segment dependent and more extensive in the distal gut. HIIT increased the alpha diversity and Bacteroidetes/Firmicutes ratio of the distal gut and fecal microbiota during diet-induced obesity. Exercise training increased the predicted genetic capacity related to the TCA cycle among other aspects of metabolism. Strikingly, the same microbial metabolism indexes that were increased by exercise were all decreased in HFD-fed vs. chow diet-fed mice. Therefore, exercise training directly opposed some of the obesity-related changes in gut microbiota, including lower metagenomic indexes of metabolism. Some host and microbial pathways appeared similarly affected by exercise. These exercise- and diet-induced microbiota interactions can be captured in feces.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity

Denou

Marcinko

Surette

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

207

175

View full text Add to dashboard Cite

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“…Moreover, an increase in Bifidobacterium spp. level was only observed in exercised non-diabetic mice, suggesting that the presence of diabetes abolished the beneficial effect of exercise [124]. Also in humans with T2D, Qin et al…”

Section: After Normalizing Bmi Diet Age Estaki Et Al Analyzed Fecmentioning

confidence: 96%

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Codella

Luzi

Terruzzi³

2018

Digestive and Liver Disease

128

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Please cite this article as: Codella Roberto, Luzi Livio, Terruzzi Ileana.Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases.Digestive and Liver Disease https://doi.org/10.1016/j.dld. 2017.11.016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractLimited animal and human research findings implied that exercise might have a

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“…Indeed, increased Bacteroidetes phyla along with decreased Firmicutes phyla within the gut have been associated with these metabolic consequences. The results obtained by Denou, et al [33] reinforce this proposition [33][34][35].…”

Section: The Effect Of Physical Exercise On the Gut Microbiotamentioning

confidence: 65%

Exercise, Nutrition and Gut Microbiota: Possible Links and Consequences

Costa¹,

Leite²,

Resende³

et al. 2017

Int J Sports Exerc Med

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Gut microbiota plays an important role in the modulation of physiological processes associated with the digestion of nutrients, immune system and control of energy homeostasis. Changes in gut microbiota composition have been associated notably with obesity, diabetes, and inflammatory diseases. Diet is one of the major factors capable of modulating the intestinal microbiota composition. In addition, the literature has shown that exercise can affect the gut microbiota composition and modulate the balance between the interaction of host and beneficial microbiota. Physical exercise improves the diversity and relative amounts of bacterial species under different nutritional contexts. However, the impact of exercise associated or not with dietary changes on the gastrointestinal environment and consequences for gut health remain poorly understood. Some proposals regarding the biological mechanisms possibly involved highlight the short chain fatty acid production and alteration in intestinal pH as main forms by which exercise may affect gut microbiota composition. Thus, the aim of the present review is to present an overview of the effects of physical exercise associated with diet on the characteristics of the intestinal microbiota.

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Exercise training modifies gut microbiota in normal and diabetic mice

Cited by 169 publications

References 27 publications

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity

High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity

Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases

Exercise, Nutrition and Gut Microbiota: Possible Links and Consequences

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