Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis

Bettariga, Francesco; Taaffe, Dennis R.; Galvão, Daniel A.; Lopez, Pedro; Bishop, Chris; Markarian, Anna Maria; Natalucci, Valentina; Kim, Jin-Soo; Newton, Robert U.

doi:10.1016/j.jshs.2024.04.005

Cited by 3 publications

(1 citation statement)

References 104 publications

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“…Studies of exercise have been in animal models or healthy younger volunteers, examined the effects of an acute bout of aerobic or resistance activity or not utilized randomized comparisons. 11 Metformin alters myokine concentrations, such as irisin, by increasing adenosine monophosphate‐activated protein kinase (AMPK) activity in skeletal muscle, sensitizing insulin‐resistant skeletal muscle and promoting muscle protein synthesis. 12 , 13 Collectively, these data suggest that exercise and metformin may have independent effects on myokine concentrations and, when paired, could produce synergistic effects consistent with an improved cancer prognosis.…”

Section: Introductionmentioning

confidence: 99%

Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial

Brown,

Spielmann,

Yang

et al. 2024

J cachexia sarcopenia muscle

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BackgroundPhysical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations.MethodsThis hypothesis‐generating analysis used biospecimens collected from a multi‐centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were quantified using a multiplex panel. Myokine concentrations were log‐transformed, and main effects analyses were conducted using linear mixed‐effects regression models. The type I error rate was controlled with the Holm sequential testing procedure.ResultsRandomization to exercise increased leukaemia inhibitory factor (1.26 pg/mL, 95% confidence interval [CI]: 0.69, 1.84; adjusted P = 0.001) and interleukin‐15 (2.23 pg/mL, 95% CI: 0.87, 3.60; adjusted P = 0.013) compared with randomization to no exercise. Randomization to metformin decreased apelin (−2.69 pg/mL, 95% CI: −4.31, −1.07; adjusted P = 0.014) and interleukin‐15 (−1.74 pg/mL, 95% CI: −2.79, −0.69; adjusted P = 0.013) compared with randomization to no metformin. Metformin decreased myostatin, irisin, oncostatin M, fibroblast growth factor 21 and osteocrin; however, these changes were not statistically significant after correction for multiple comparisons.ConclusionsThis pilot study demonstrates that randomization to exercise and metformin elicit unique effects on myokine concentrations in cancer patients. This hypothesis‐generating observation warrants further basic, translational and clinical investigation and replication.

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Section: Introductionmentioning

confidence: 99%

Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial

Brown,

Spielmann,

Yang

et al. 2024

J cachexia sarcopenia muscle

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Exerkine response to acute exercise: Still much to discover

Valenzuela,

Rivas-Baeza,

Fiuza-Luces

et al. 2024

Journal of Sport and Health Science

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Research on Sports Training Mode of College Athletes Based on Column Generation Algorithm of Recursive Matrix

2024

Applied Mathematics and Nonlinear Sciences

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Athlete training optimization is an important part of sports management, and the scientific management program is of practical significance for athletes to improve their sports level. This paper collects sports training data for cluster analysis, establishes the optimization function of the distance from the data point to the center of the class, solves it, and determines the consistency matrix to judge the data category. Establish the column generation optimization model, get the linear programming model based on the matrix change column generation, in the process of transforming the model to solve the recursive matrix recursive relationship formula and solve the objective function. According to the solution of the optimization function to adjust the athletes’ sports training program. After the test, it was found that the pre-and post-test scores of the three tests of the experimental class were improved by 1.03 seconds, 1.05 meters, and 1.33 meters, respectively, and were significantly ahead of the scores of the control group. According to the satisfaction analysis, 76.67% of students were satisfied with the training effect. It indicates that the new training mode improved by the algorithm has good application effects.

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Exercise training mode effects on myokine expression in healthy adults: A systematic review with meta-analysis

Cited by 3 publications

References 104 publications

Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial

Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial

Exerkine response to acute exercise: Still much to discover

Research on Sports Training Mode of College Athletes Based on Column Generation Algorithm of Recursive Matrix

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