Exercise training mitigates anthracycline‐induced chronic cardiotoxicity in a juvenile rat model

Abstract

Exercise training, initiated at the time treatment begins, can protect against delayed-onset anthracycline-induced cardiotoxicity in adult rats that were treated with anthracyclines as juveniles.

Cardiotoxicity of Doxorubicin Treatment and Physical Activity: A Systematic Review

“…Studies by Chicco et al 11 and Hayward et al 7 used fractionated doses of 15mg/kg and 14mg/kg, respectively. The first study 11 used a fractionated dose of 2.5mg/kg three times a week; the results indicated a protection against left ventricular dysfunction and inhibition of the increase in apoptosis signaling.…”

“…Also, no effect of exercise was observed on HSP levels or antioxidant metabolism. 11 The second study 7 used a fractionated dose of 2mg/kg/day for one week. In this study, 7 the exercise was effective in preventing the decrease in cardiac growth curve, body mass and cardiac functions.…”

“…11 The second study 7 used a fractionated dose of 2mg/kg/day for one week. In this study, 7 the exercise was effective in preventing the decrease in cardiac growth curve, body mass and cardiac functions. The study by Marques-Aleixo et al 27 also used a treatment protocol with a fractionated dose of 2mg/kg (one dose per week) for 7 weeks; exercise improved mitochondrial bioenergetics and prevented oxidative stress-induced damage.…”

“…6 Depending on the therapy, users of oncology services may have a 15-fold increased chance of suffering heart failure. 7 In this regard, it is worth mentioning the cardioprotective properties of exercise in the context of cardiovascular diseases, highlighted by previous studies, 8 as an incentive for studies on exercise and cardiotoxic chemotherapy agents. Doxorubicin (DOX) was selected for this review, since it is a chemotherapy drug used in the treatment of a wide range of cancers, with a high evidence level of cardiotoxicity.…”

“…[10][11][12][13][14][15]17,18,20,[22][23][24][25]27 . A study 7 on male rats aimed to determine whether physical exercise had a cardioprotective effect on juvenile rats treated with DOX. Four studies 9,16,19,26 were performed on female animals due to protocol particularities and/or to simulate treatment conditions as similar as possible to human conditions.…”