Exercise Training in Women with Heart Disease: Influence of Hormone Replacement Therapy

Abstract

The cardiovascular responses to training in postmenopausal women with CAD appear to be consistent regardless of HRT status and dominated by peripheral adaptations.

Aerobic exercise training in healthy postmenopausal women

“…To highlight this, in the Discussion, under the section entitled 'HT and Exercise Training Influences on Maximal Oxygen Uptake', we have amended our manuscript to read: 'Others have also reported no effect of varying hormonal preparations and dosages of HT on VO2 peak after endurance training. 23,[33][34][35] ' We have also added the following to the Limitations section (p17): 'It is possible our chosen hormone regimen may not have conferred optimal benefit to central and peripheral function. Alternative hormonal preparations, dosages and/or duration of treatment may have impacted our parameters of interest differently.…”

“…18,19 Meanwhile, the administration of HT in women for the relief of menopausal and uro-genital symptoms to avoid fractures and atrophy of connective tissue continues to be advocated. 20 In shown to be independent of HT status in health 22 and disease, 23 no controlled studies have been reported. As such, the purpose of this study was to examine the influence of HT on central and peripheral function before and after 12 weeks of aerobic exercise training using a randomized, placebo control design in healthy PMW.…”

Maximal and submaximal aerobic fitness in postmenopausal women: influence of hormone-replacement therapy

“…No difference in _ V O 2 max related to HRT use has been reported in healthy sedentary women (Johnson et al 2002;McCole et al 2000;Kirwan et al 2004;Moreau et al 2003;Snabes et al 1996) or in endurance-trained women (Green et al 1998;McCole et al 2000;Moreau et al 2002). In contrast, a greater _ V O 2 max in women taking HRT has been observed in sedentary women (Jurca et al 2004;Mercuro et al 2007), in women at risk for coronary artery disease (CAD) (Redberg et al 2000), and in women with CAD (Kirwan et al 2003). A definitive consensus concerning the effect of HRT on aerobic power is confounded by comparisons of samples that differ in age, in levels of physical activity (sedentary or endurance-trained groups), in the presence of disease (healthy or CAD samples), and in the length of HRT use.…”

Efeitos da terapia de reposição estrogênica nas respostas hemodinâmicas e neurais ao exercício físico agudo em mulheres no período pós-menopausa

“…Um dos principais sintomas vasomotores deste período são os fogachos que são caracterizados por intenso calor que se inicia no tórax e aumenta em direção ao pescoço e face 11 . 67 .…”