Background: Knee Osteoarthritis affects the entire joint, causing synovial inflammation, cartilage injury, bone remodeling, and the development of osteophytes. Pain, muscle fatigue, joint dysfunction, brief morning stiffness, crepitus, and functional limitations are the common symptoms of knee osteoarthritis.Pain Neuro Science Education (PNE) produces wonderful effects in altering the pain perception of patients by changing their perspective towards pain and reducing pain catastrophization.Methodology A 61 year old female primarily complaining of pain in her right knee (9 on NPRS) along with crepitus, swelling and painful knee flexionfor which shereceived conventional physiotherapy treatment (Cryotherapy, IFT, Ultrasound, strengthening exercises) along with pain neuroscience education PNE (Neurobiology of pain, Education about the pathology of OA, Audio visual aids 30 min session for 5 days Outcome measures were NPRS for pain, pain catastrophizing scale (PCS).Result: PNE has/was shown an additive effect on overall reducing pain and pain catastrophizing along with the conventional physiotherapy treatment.