Exercise training in chronic heart failure: effects on pro-inflammatory markers

Niebauer, Josef; Clark, Andrew L.; Webb-Peploe, Katharine; Coats, Andrew J.S.

doi:10.1016/j.ejheart.2004.07.012

Cited by 60 publications

(67 citation statements)

References 36 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[189][190][191] Plasma sCD14 concentration has also been linked to the pathophysiology of other inflammatory disease states. [192][193][194][195] To our knowledge, only 1 group has examined the effect of exercise training on sCD14. 192 Exercise training did not alter sCD14; however, these researchers employed a modest subject number (n = 18) and only 8 weeks of exercise.…”

Section: Accessory Proteinsmentioning

confidence: 99%

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

Flynn

McFarlin

Markofski³

2007

American Journal of Lifestyle Medicine

108

View full text Add to dashboard Cite

The list of diseases with a known inflammatory etiology is growing. Cardiovascular disease, osteoporosis, diabetes, geriatric cachexia, and Alzheimer's disease have all been shown to be linked to or exacerbated by aberrantly regulated inflammatory processes. Nevertheless, there is mounting evidence that those who are physically active, or who become physically active, have a reduction in biomarkers associated with chronic inflammation. There was strong early consensus that exercise-induced reductions in inflammation were explained by body mass index or body fatness, but recent studies provide support for the contention that exercise has body fatindependent anti-inflammatory effects. With few exceptions, the anti-inflammatory effects of exercise appear to occur regardless of age or the presence of chronic diseases. What remains unclear are the mechanisms by which exercise training induces these anti-inflammatory effects, but there are several intriguing possibilities, including release of endogenous products, such as heat shock proteins; selective reduction of visceral adipose tissue mass or reducing infiltration of adipocytes by macrophages; shift in immune cell phenotype; cross-tolerizing effects; or exerciseinduced shifts in accessory proteins of toll-like receptor signaling. However, future research endeavors are likely to uncover additional potential mechanisms, and it could be some time before functional mechanisms are made clear. In summary, the potential anti-inflammatory influences of exercise training may provide a low-cost, readily available, and effective treatment for low-grade systemic inflammation and could contribute significantly to the positive effects of exercise training on chronic disease. Keywordsanti-inflammatory; exercise training; chronic disease Cardiovascular disease, diabetes, osteoporosis, and several other chronic diseases are now known to be strongly linked to inflammatory processes. [1][2][3][4] Chronic diseases linked to inflammation are known to occur in greater frequency in older and sedentary individuals, 5 but evidence is emerging that exercise has anti-inflammatory effects. [6][7][8][9] For example, there is a substantial reduction in biomarkers of low-grade systemic inflammation in physically active adults or adults who undertake exercise training. [10][11][12][13][14] Address for correspondence: Michael G. Flynn, FACSM, Wastl Human Performance Lab, Department of Health and Kinesiology, Purdue University West Lafayette, IN 47907; mickflyn@purdue.edu. NIH Public Access Author ManuscriptAm J Lifestyle Med. Author manuscript; available in PMC 2014 November 25. NIH-PA Author ManuscriptChronic low-grade inflammation, "persistent but more subtle than the acute phase response," 15 is frequently assessed by measurement of circulating C-reactive protein (CRP) and, somewhat less frequently, serum amyloid A. C-reactive protein concentration is higher in those with high body mass index, 16,17 metabolic syndrome and/or diabetes, 1,18 belownormal high-density lipoprotein choleste...

show abstract

Section: Accessory Proteinsmentioning

confidence: 99%

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

Flynn

McFarlin

Markofski³

2007

American Journal of Lifestyle Medicine

108

View full text Add to dashboard Cite

show abstract

“…In addition to improving functional capacity and survival, other evidence has shown positive results of this therapy, such as an increasing in circulating endothelial progenitor cells 53 , anti-inflammatory effects and effects on the endothelium, and changing in levels of interleukin-1β 54 , -6 54,55 , -10 56 , tumor necrosis factor-α and its receptors 1 and 2 and C-reactive protein 56 , inducible nitric oxide synthase (iNOS) 54 , soluble intracellular adhesion molecule (sICAM) 55 , adiponectin 57,58 , brain natriuretic peptide (BNP) 59 and others (Fig. 2).…”

Section: Perspectivesmentioning

confidence: 99%

Exercício físico e microRNAs: novas fronteiras na insuficiência cardíaca

Fernandes-Silva¹,

Carvalho²,

Guimarães³

et al. 2012

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

Although the impact of exercise on survival of patients with heart failure has been recently questioned, exercise training improves quality of life, functional capacity, inflammation, endothelial and autonomic function. In recent years, interest has increased regarding a group of small non-protein coding RNAs called microRNAs.Studies have shown that the expression of these molecules changes in several pathological conditions, such as myocardial infarction, myocardial ischemia and heart failure, and when clinical improvement occurs, they seem to normalize. With the potential for practical applicability, markers that may be useful in diagnostic and prognostic assessment of heart failure have been identified, such as miR-423-5p. In addition, results of experimental studies have indicated that there are potential therapeutic effects of microRNAs.MicroRNAs are involved in the regulation of gene expression during fetal development and in adult individuals, increasing or decreasing in the heart in response to physiological stress, injury or hemodynamic overload. Thus, the study of the behavior of these molecules in physical exercise has brought important information about the effects of this therapeutic modality and represents a new era in the understanding of heart failure.This review aims to integrate the evidence on microRNAs in heart failure with greater relevance in the study of physical exercise.

show abstract

“…Similar home-based activity programs have targeted healthy populations as well as a variety of clinical populations such as those with heart failure, cancer, sporadic inclusion body myositis, chronic obstructive pulmonary disorder, and outcomes associated with various inflammatory responses. 12,13,17 To date, there have been no published investigations that incorporate a homebased exercise approach for PLWHA.…”

Section: Introductionmentioning

confidence: 99%

“…4,[7][8][9][10][11][12][13] Many of the physiological benefits of activity are a direct result of metabolic improvements (i.e. improved lipid panel, reduced waist circumference and body fat, etc.)…”

Section: Introductionmentioning

confidence: 99%

Results of a nine month home-based physical activity intervention for people living with HIV

Jaggers¹,

Sneed²,

Lobelo³

et al. 2016

Int J Clin Trials

View full text Add to dashboard Cite

Background: The purpose of this investigation was to test the feasibility of a home-based moderate-intensity physical activity (MPA) program for people living with HIV/AIDS (PLWHA) currently taking antiretroviral therapy (ART).Methods: 68 participants recruited for a 9-month home-based PA intervention aimed to reduce risk factors of cardiovascular disease for PLWHA taking ART. All participants received an educational weight loss workbook and a pedometer for self-monitoring of physical activity. The intervention group received elastic Therabands® for strength training in addition to telephone based behavioural coaching. Clinical assessments were conducted at baseline and each follow-up which also included psychometric questionnaires and PA levels via the SenseWear® armband accelerometer.Results: Of the 57 completing the study, 29 of those were in the intervention group and 28 were in the standard care group. Results show that the home-based PA intervention was not successful in increasing the total amount of MPA for PLWHA. However there was a trend (p=0.08) of decreasing sedentary time. In a secondary analysis those who increased PA by >10% observed decreases in waist circumference and improved functioning at 18 weeks. None of the changes observed were significant after controlling for all potential confounders. Conclusions: A home-based exercise approach with telephone-based coaching may not be a feasible method for increasing MPA among PLWHA. Slight decreases in sedentary time indicate some positive changes in activity habits. A possible strategy to improve studies similar to this is to incorporate a group based social interaction each week similar to that of a support group.

show abstract

Exercise training in chronic heart failure: effects on pro-inflammatory markers

Cited by 60 publications

References 36 publications

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training

Exercício físico e microRNAs: novas fronteiras na insuficiência cardíaca

Results of a nine month home-based physical activity intervention for people living with HIV

Contact Info

Product

Resources

About