Exercise training improves the antioxidant enzyme activity with no changes of telomere length

Shin, Yun-A; Lee, Jun-Hyoup; Song, Wook; Jun, Tae-Won

doi:10.1016/j.mad.2008.01.001

Cited by 106 publications

(104 citation statements)

References 46 publications

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“…The negative association between physical activity and SOD activity is in agreement with several previous studies [26][27][28], but not with other studies [29,30]. The specific reasons for this inconsistency are still unclear, but could be explained by dynamic response of antioxidants against ROS [31,32].…”

Section: Discussionsupporting

confidence: 87%

Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women

Yang¹,

Jensen²

2015

J Community Med Health Educ

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Objectives: The associations between physical activity and oxidative stress biomarkers are still controversial, and few large human studies have comprehensively investigated the relationship between physical activity and oxidative stress biomarkers. The purpose of this study was to examine the association between physical activity and oxidative stress biomarkers in a large sample of women by measuring biomarkers of both oxidation and antioxidant defense.Design and Methods: We conducted a cross-sectional study among 1,144 generally healthy women ages 43-70 years, who were included in a prospective nested case-control study of coronary heart disease in the Nurses' Health Study. Fluorescent oxidation products (FlOPs) are oxidation markers reflecting global oxidation burden. Antioxidant defense was quantified by the activities of three major antioxidant enzymes in erythrocyte (superoxide dismutase [SOD], glutathione peroxidase [GPx] and catalase [CAT]). Self-reported physical activity was estimated in metabolic equivalents per week.Results: Physical activity was not associated with FlOP levels, or GPx and CAT activities after adjusting for covariates (all Ptrend>0.15). Higher levels of physical activity were associated with decreased SOD activity (Ptrend<0.01). We then conducted subgroup analysis of participants with and without any vigorous physical activity. Greater levels of physical activity were associated with lower SOD activity among participants with any vigorous physical activity (Ptrend=0.02).Conclusions: Greater physical activity was associated with lower SOD activity, but not with higher plasma FlOPs in generally healthy women. Our findings may be important for women to maintain a low level of oxidative stress during exercise because high oxidative stress is related to the development of many chronic diseases

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Section: Discussionsupporting

confidence: 87%

Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women

Yang¹,

Jensen²

2015

J Community Med Health Educ

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“…This trend toward longer telomeres was detected not only in the whole CD4 + and CD8 + T cell compartments but also in their respective CD45RO + /CD45RO neg and CD28 + /CD28 neg subsets, although statistical significance was observed only in the total CD8 + and CD8 + CD28 neg compartments between the IT and NT groups. These data are particularly important because previous studies on telomere length and physical activity showed conflicting results (Cherkas et al 2008;Ludlow et al 2008;Shin et al 2008;Woo et al 2008;Du et al 2012;Laine et al 2015). Comparisons among these studies are limited by differences in study design, including the immunological parameters assessed and the cohorts analyzed, which differed not only in age and gender but also in the type, intensity, and regularity of physical activity.…”

Section: Discussionmentioning

confidence: 95%

“…Telomere shortening has been considered a marker of immunosenescence. The impact of regular exercise on telomere length remains controversial, with studies showing either no effect (Shin et al 2008;Woo et al 2008;Laine et al 2015) or a protective effect (Cherkas et al 2008;Ludlow et al 2008;Du et al 2012). Therefore, we measured and compared telomere length in total T cells [CD3 + ], CD4 + CD45RO + T cells, CD4 + CD45RO neg T cells, CD8 + CD28 + T cells, and CD8 + CD28 neg T cells among the groups.…”

Section: Telomere Lengthmentioning

confidence: 99%

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Silva

Araújo

Fernandes

et al. 2016

AGE

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Studies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4 + /TCD8 + naïve compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA + CCR7 neg ) TCD4 + and TCD8 + cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4 + cells, while IT was associated with higher proportion of effector memory TCD8 + cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28 neg ) TCD8 + cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8 + cells, whereas with MT, a modest increase in telomere length was observed in both TCD8 + and TCD4 + cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT.

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“…It is reported that CP-induced nephrotoxicity may be ameliorated by scavenging agents such as vitamins E and C, losartan, melatonin, selenium, superoxide dismutase, and erythropoietin (10)(11)(12)(13)(14)(15)(16). Researches indicate that exercise activity changes antioxidant content (17)(18)(19), and as an example, it reduces antioxidant levels of erythrocyte GSH-PX (17). Also, moderate regular exercise decreased malondialdehyde (MDA) levels (20).…”

Section: Introductionmentioning

confidence: 99%

“…Also, moderate regular exercise decreased malondialdehyde (MDA) levels (20). Another study showed long-term aerobic exercise increases glutathione erythrocyte peroxidase enzyme (GSH) activity and superoxide dismutase (SOD) activity (18). Physical exercise has been suggested in cancer patients undergoing chemotherapy (21,22) to improve mental and physical activities and rehabilitation, because exercise increases heart-respiratory fitness and muscular strength, and improves body composition.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

et al. 2015

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Background: Cisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs. Objectives: This study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity. Materials and Methods: Thirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation. Results: CP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P < 0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P < 0.05). Conclusions: Aerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.

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Exercise training improves the antioxidant enzyme activity with no changes of telomere length

Cited by 106 publications

References 46 publications

Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women

Physical Activity and Oxidative Stress Biomarkers in Generally Healthy Women

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

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