Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Bachi, André Luís Lacerda; Rocha, Gislene A.; Sprandel, Marília Co; Ramos, Luiz Roberto; Gravina, Cláudia F.; Pithon‐Curi, Tania C.; Vaisberg, Mauro; Maranhão, Raul C.

doi:10.1111/jgs.13500

Cited by 15 publications

(10 citation statements)

References 11 publications

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“…Our data indicates the cardiovascular benefits of ASE training; and these benefits are more apparent when systemic inflammation is reduced in addition to increased serum HDL-cholesterol level. What's more, our results are compatible with several other findings which reveal improvements concerning CVD risk factors in elderly subjects post exercise training 32 , 37, 38, 39…”

Section: Discussionsupporting

confidence: 92%

Effects of arm swing exercise training on cardiac autonomic modulation, cardiovascular risk factors, and electrolytes in persons aged 60–80 years with prehypertension: A randomized controlled trial

Prasertsri

Singsanan

Chonanant

et al. 2019

Journal of Exercise Science & Fitness

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Background/ObjectiveThis study aimed to investigate the effect and carry-over effect of arm swing exercise (ASE) training on cardiac autonomic modulation, cardiovascular risk factors, and blood electrolytes in older persons with prehypertension.MethodsSubjects were 50 individuals with prehypertension (aged 66.90 ± 5.50 yr, body mass index 23.84 ± 3.65 kg/m2). They were randomly assigned into ASE group and control group. Subjects in the ASE group underwent an ASE training program for 3 months at a frequency of 30 min/day, 3 days/week. Subjects in the control group maintained their daily routine activities minus regular exercise. Blood pressure, heart rate variability (HRV), cardiovascular risk factors including blood glucose, lipid profile, high-sensitive C-reactive protein (hsCRP), and electrolytes were evaluated on 3 occasions: before and after the 3-month intervention, and 1 month after intervention ended.ResultsFollowing the 3-month intervention, systolic blood pressure (SBP) and serum hsCRP concentration were significantly lower, while serum high-density lipoprotein (HDL)-cholesterol, potassium (K+), magnesium (Mg2+) concentrations, standard deviation of normal R-R intervals (RMSSD) and high frequency (HF) power values were higher in the ASE group when compared with the control group (p < 0.05). At the 1-month follow-up interval, SBP and serum hsCRP concentration remained lower while serum HDL-cholesterol and K+ concentrations remained higher in the ASE group as compared to the control group (p < 0.05).ConclusionASE training decreased SBP and serum hsCRP concentration, increased serum HDL-cholesterol, K+, and Mg2+ concentrations and increased RMSSD and HF power values in older persons with prehypertension. In addition, there were carry-over effects of ASE training i.e. decreased SBP and serum hsCRP concentration as well as increased serum HDL-cholesterol and K+ concentrations.

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Section: Discussionsupporting

confidence: 92%

Effects of arm swing exercise training on cardiac autonomic modulation, cardiovascular risk factors, and electrolytes in persons aged 60–80 years with prehypertension: A randomized controlled trial

Prasertsri

Singsanan

Chonanant

et al. 2019

Journal of Exercise Science & Fitness

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“…Among these functions, HDL is the main lipoprotein to exert cholesterol esterification and reverse cholesterol transport and has also many other protective functions such as antioxidant, promoter of vasodilation, antiapoptotic, and anti-inflammatory [40]. Previously, we have shown that combined aerobic-resistance exercise training performed in aged women increased the transfer of cholesterol to HDL [41]. This effect is presumably beneficial, since patients with cardiovascular disease exhibit low cholesterol transfer values compared to controls without the disease [42, 43].…”

Section: Discussionmentioning

confidence: 99%

Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis

Bachi

Barros

Rocha

et al. 2019

Oxidative Medicine and Cellular Longevity

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Cardiovascular benefits for the general population of combined aerobic-resistance exercise training are well-known, but the impact of this exercise training modality on the plasma lipid, inflammatory, and antioxidant status in elderly women that are exposed to a great risk of developing ischemic cardio- and cerebrovascular diseases has not been well investigated. So, we aimed to evaluate the plasma lipids, oxidative stress, and inflammatory cytokines in 27 elderly women (TRAINED group, 69.1±8.1 yrs) that were performing moderate intensity combined aerobic-resistance exercise training (3 times/week for at least 18 months) and in 27 sedentary elderly women (SED group, 72.0±6.4 yrs), not submitted to exercise training for at least 5 yrs. Our results showed that BMI was lower in the TRAINED group than in the SED group (25.1±3.2 vs. 28.7±5.1, p<0.05). The TRAINED group had lower glycemia (92±3 vs. 118±12, p<0.05), glycated hemoglobin (5.9±0.1 vs. 6.4±0.2, p<0.05), and triglycerides (98 (75-122) vs. 139 (109-214), p<0.01); equal total cholesterol (199 (175-230) vs. 194 (165-220)), LDL-cholesterol (108 (83-133) vs. 109 (98-136)), and non-HDL-cholesterol (54 (30-74) vs. 62 (26-80)); and also higher HDL-cholesterol (64 (52-77) vs. 52 (44-63), p<0.01) and LDL-C/oxLDL ratio (13378±2570 vs. 11639±3113, p<0.05) compared to the SED group. Proinflammatory cytokines as IL-1β (11.31±2.4 vs. 28.01±4.7, p<0.05), IL-6 (26.25±7.4 vs. 49.41±17.8, p<0.05), and TNF-α (25.72±2.8 vs. 51.73±4.2, p<0.05) were lower in the TRAINED group than in the SED group. The TRAINED group had lower total peroxides (26.3±7.4 vs. 49.0±17.8, p<0.05) and oxidized LDL (1551±50.33 vs. 1773±74, p<0.02) and higher total antioxidant capacity (26.25±7.4 vs. 49.41±17.8, p<0.001) compared to the SED group. In conclusion, in TRAINED women, BMI was lower, plasma lipid profile was better, plasma oxidative stress was diminished, and there was less expression of proinflammatory interleukins than in SED, suggesting that combined aerobic-resistance exercise training may promote the protection against the complications of ischemic cardio- and cerebrovascular disease in elderly women.

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“…[6] for review). On the other hand, conditions that are favorable to atherosclerosis prevention, such as physical training, increase the transfers of cholesterol to HDL [29]. Therefore, the results of the previous studies suggest that the presence of cardiovascular disease or other unhealthy conditions are associated with decrease in the transfer of cholesterol to the HDL fraction.…”

Section: Discussionmentioning

confidence: 98%

Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma

et al. 2020

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Background: Androgen deprivation therapy (ADT) is widely used in the treatment of testosterone-dependent prostate carcinomas. ADT often increases plasma LDL and HDL cholesterol and triglycerides. The aim was to test whether ADT changes the transfer of lipids to HDL, an important aspect of this metabolism and HDL protective functions, and related parameters. Methods: Sixteen volunteers with advanced prostate carcinoma submitted to pharmacological ADT or orchiectomy had plasma collected shortly before and after 6 months of ADT. In vitro transfer of lipids to HDL was performed by incubating plasma with donor emulsion containing radioactive lipids by 1 h at 37°C. After chemical precipitation of apolipoprotein B-containing lipoprotein, the radioactivity of HDL fraction was counted. Results: ADT reduced testosterone to nearly undetectable levels and markedly diminished PSA. ADT increased the body weight but glycemia, triglycerides, LDL and HDL cholesterol, HDL lipid composition and CETP concentration were unchanged. However, ADT increased the plasma unesterified cholesterol concentration (48 ± 12 vs 56 ± 12 mg/dL, p = 0.019) and LCAT concentration (7.15 ± 1.81 vs 8.01 ± 1.55μg/mL, p = 0.020). Transfer of unesterified (7.32 ± 1.09 vs 8.18 ± 1.52%, p < 0.05) and esterified cholesterol (6.15 ± 0.69 vs 6.94 ± 1.29%, p < 0.01) and of triglycerides (6.37 ± 0.43 vs 7.18 ± 0.91%, p < 0.001) to HDL were increased after ADT. Phospholipid transfer was unchanged.

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Exercise Training Improves Plasma Lipid and Inflammatory Profiles and Increases Cholesterol Transfer to High‐Density Lipoprotein in Elderly Women

Cited by 15 publications

References 11 publications

Effects of arm swing exercise training on cardiac autonomic modulation, cardiovascular risk factors, and electrolytes in persons aged 60–80 years with prehypertension: A randomized controlled trial

Effects of arm swing exercise training on cardiac autonomic modulation, cardiovascular risk factors, and electrolytes in persons aged 60–80 years with prehypertension: A randomized controlled trial

Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis

Androgen deprivation therapy improves the in vitro capacity of high-density lipoprotein (HDL) to receive cholesterol and other lipids in patients with prostate carcinoma

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