Exercise training improves hypertension-induced autonomic dysfunction without influencing properties of peripheral cardiac vagus nerve

Neto, Octávio Barbosa; Sordi, Carla Cristina de; Mota, Gustavo Ribeiro da; Marocolo, Moacir; Chriguer, Rosângela Soares; Silva, Valdo José Dias da

doi:10.1016/j.autneu.2017.09.012

Cited by 13 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, our findings are supported by other evidence in the literature showing that sodium‐induced dysfunctions in the neurochemistry of brain autonomic nuclei that control BP could contribute to changes in sympathetic drive as well (Adams et al., 2007, 2008; Huang et al., 1998, 2004; Huysse et al., 2012; Kawano et al., 1992; Ribeiro et al., 2020; Toney et al., 2003). Swimming exercise training restored the hexamethonium‐induced hypotension of HS rats, which supports the idea that autonomic adaptations to swimming training largely contribute to its anti‐hypertensive effects (Barbosa Neto et al., 2013; Cox et al., 1985; Lemos et al., 2018; Neto et al., 2017). Other studies further corroborate the hypothesis that the reduction in the BP levels due to regular exercise training could be sympathetically mediated since Wistar rats fed 8% NaCl diet and exercise‐trained on a treadmill showed BP restored to the basal levels and attenuation of sympathoexcitation (Li et al., 2018).…”

Section: Discussionsupporting

confidence: 68%

Swimming training improves cardiovascular autonomic dysfunctions and prevents renal damage in rats fed a high‐sodium diet from weaning

Souza

Becker

Batista

et al. 2020

Experimental Physiology

View full text Add to dashboard Cite

High sodium intake is an important factor associated with hypertension. High-sodium intake with exercise training can modify homeostatic hydro-electrolytic balance, but the effects of this association are mostly unknown. In this study, we sought to investigate the effects of swimming training (ST) on cerebrospinal fluid (CSF) Na + concentration, sympathetic drive, blood pressure (BP) and renal function of rats fed a 0.9% Na + (equivalent to 2% NaCl) diet with free access to water for 22 weeks after weaning. Male Wistar rats were assigned to two cohorts: (1) fed standard diet (SD) and (2) fed high-sodium (HS) diet. Each cohort was further divided into trained and sedentary groups. ST normalised BP levels of HS rats as well as the higher sympathetically related pressor activity assessed by pharmacological blockade of ganglionic transmission (hexamethonium). ST preserved the renal function and attenuated the glomerular shrinkage elicited by HS. No change in blood volume was found among the groups. CSF [Na + ] levels were higher in sedentary HS rats but were reduced by ST. Our findings showed that ST effectively normalised BP of HS rats, independent of its effects on hydro-electrolytic balance, which might involve neurogenic mechanisms regulated by Na + levels in the CSF as well as renal protection.

show abstract

Section: Discussionsupporting

confidence: 68%

Swimming training improves cardiovascular autonomic dysfunctions and prevents renal damage in rats fed a high‐sodium diet from weaning

Souza

Becker

Batista

et al. 2020

Experimental Physiology

View full text Add to dashboard Cite

show abstract

“…Our results also concur with previous studies showing that exercise increased the vagal cardiovascular tone (Bonaz et al, 2017; Carnevali and Sgoifo, 2014; Ulloa et al, 1998). But, other study reported that exercise modulates cardiovascular but not through the vagus nerve (Neto et al, 2017). Thus, the effects of exercise on vagal activity are controversial depending on the physical activity.…”

Section: Discussionmentioning

confidence: 99%

Exercise activates vagal induction of dopamine and attenuates systemic inflammation

Shimojo

Joseph

Shah

et al. 2019

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Physical exercise is one of the most important factors improving quality of life, but it is not feasible for patients with morbidity or limited mobility. Most previous studies focused on high-intensity or long-term exercise that causes metabolic stress or physiological adaption, respectively. Here, we studied how moderate-intensity swimming affects systemic inflammation in 6–8 week old C57BL/6J male mice during endotoxemia. One-hour swimming prevented hypokalemia, hypocalcemia, attenuated serum levels of inflammatory cytokines, increased anti-inflammatory cytokines but affected neither IL6 nor glycemia before or after the endotoxic challenge. Exercise attenuated serum TNF levels by inhibiting its production in the spleen through a mechanism mediated by the subdiaphragmatic vagus nerve but independent of the splenic nerve. Exercise increased serum levels of dopamine, and adrenalectomy prevented the potential of exercise to induce dopamine and to attenuate serum TNF levels. Dopaminergic agonist type-1, fenoldopam, inhibited TNF production in splenocytes. Conversely, dopaminergic antagonist type-1, butaclamol, attenuated exercise control of serum TNF levels. These results suggest that vagal induction of dopamine may contribute to the anti-inflammatory potential of physical exercise.

show abstract

“…68,69,71,72 Modulation of the autonomic nervous system with diminished sympathetic tone, increased vagal activity, and augmented baroreflex sensitivity in response to exercise training was identified as an underlying mechanism in animals and patients. 73,74 Restoration of autonomic balance in combination with improved peripheral endothelial function and decreased blood pressure reduces cardiac afterload and improves left ventricular diastolic function. 42,75,76 Exercise training was shown to induce reverse cardiac remodeling in patients with heart failure with reduced left ventricular ejection fraction.…”

Section: Adaptation Of the Heart And The Vasculature In Response To Ementioning

confidence: 99%

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Winzer

Woitek

Linke

2018

JAHA

155

100

View full text Add to dashboard Cite

Exercise training improves hypertension-induced autonomic dysfunction without influencing properties of peripheral cardiac vagus nerve

Cited by 13 publications

References 41 publications

Swimming training improves cardiovascular autonomic dysfunctions and prevents renal damage in rats fed a high‐sodium diet from weaning

Swimming training improves cardiovascular autonomic dysfunctions and prevents renal damage in rats fed a high‐sodium diet from weaning

Exercise activates vagal induction of dopamine and attenuates systemic inflammation

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Contact Info

Product

Resources

About