Exercise Training for Claudication

Stewart, Kerry J.; Hiatt, William R.; Regensteiner, Judith G.; Hirsch, Alan T.

doi:10.1056/nejmra021135

Cited by 456 publications

(290 citation statements)

References 108 publications

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“…12,17,18 Another important factor in patients with PVI is the presence of pain in areas distal to damage caused by ischemia provoked by the pathology itself 19 and, as a result, these patients tend to have lower physical activity levels and impaired walking capacity, all of which results in a general process of loss of fitness, inactivity and worsened quality-of-life. 20 Arterial damage may be exacerbated by the abnormal hemodynamic response, chronic venous insufficiency or heart failure; it was notable that patients with PVI achieved shorter distances in the 6MWT than patients with HF alone. Although the results for quality of life were not different between the groups, it can be observed that in the present study day-to-day activities, represented by the 6MWT, CT and ST, were impaired for patients with HF+PVI.…”

Section: Discussionmentioning

confidence: 99%

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

et al. 2014

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INTRODUCTION: Heart failure (HF) is a complex syndrome in which effort limitation is associated with deterioration of peripheral musculature. Improving survival rates among these patients have led to the appearance of cases in which other pathologies are associated with HF, such as peripheral vascular insufficiency (PVI). The combination of these two pathologies is common, with significant repercussions for affected patients. OBJECTIVE: To compare functional limitations and quality of life between patients with HF in isolation or HF + PVI. METHOD: Twelve patients with HF+PVI were paired to 12 patients with HF in isolation. All had ejection fraction <40%. The following were conducted: 6 minute walk test (6MWT), chair test (CT), step test (ST), one repetition maximum test (1RM) and quality of life questionnaire. RESULTS: The results for the 6MWT (311±27 vs. 447±29), ST (49±3 vs. 81±10) and CT (17±1 vs. 21±1) were lower in the HF+PVI group than in the HF group (p<0.05). The HF+PVI group exhibited a reduction in the number of steps taken from the first to the second minute of the ST, in relation to the HF group. The HF group exhibited better HR recovery than the HF+PVI group (50±4 vs. 26±3; p<0.05). No differences were found in results for the Borg scale, the peripheral muscle strength test (1RM) or the questionnaires (p>0.05). CONCLUSIONS: The study participants who had mixed disease exhibited a greater degree of functional impairment than the group with HF, without reporting worsened quality of life.

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Section: Discussionmentioning

confidence: 99%

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

et al. 2014

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“…14,15,29,30 This scenario of reduced physical capacity due to PAOD, increases the levels of a more sedentary lifestyle, which provokes in end a "progressive disability cycle" of physical function. 31 In this field, scientific literature has been previously documented reduced values of strength, power and endurance in patients when compared with non diseased controls. [7][8][9]16,17,30,[32][33][34] Once muscular strength could be strongly correlated with walking capacity (most accessed measure of fitness capacity) in PAOD patients by Regensteiner et al 34 and Gerdle et al 32 interventions (resistance training) to counteract this condition has been proposed 11,12 and studied with documented positive benefits.…”

Section: Functionalmentioning

confidence: 99%

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

2013

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Creatine (Cr) Supplementation has been efficient and safely used as a therapeutic aid in many health and sickness conditions including muscle weakness, atrophy and metabolic disturbances. In Peripheral arterial obstructive disease (PAOD), chronic ischemia leads to muscle fiber atrophy and denervation, negative muscle metabolism alterations, thus reducing strength and endurance, impairing general physical fitness. Adding the studied benefits of Cr supplementation and the clinical frame of PAOD, it presents Cr Supplementation as a potential therapeutic aid to be considered. Objective: To make a systematic review in scientific literature, searching for studies involving Cr supplementation in PAOD individuals. Method: A search for Portuguese and English written articles, published over the last ten years, including terms related to PAOD and Cr supplementation, was conducted on PubMed SciELO, and LILACS. Results: Only one study evaluated the influence of Cr supplementation in the desired sample (PAOD), describing positive effects in walking distance and blood properties. Due to lack of scientific data, the use Cr supplementation in PAOD population, including metabolic, functional and structural considerations was discussed. Conclusion: Despite the presented discussion for using Cr supplementation in PAOD as a potential therapeutic aid, only one previous study could verify its benefits. Therefore, it still has a gap in scientific literature, leaving several possibilities for future studies researching for possible benefits to counteract the loss of functional fitness and impairments in musculoskeletal structure and metabolism of diseased individuals. Keywords: Creatine, Peripheral Arterial Disease/rehabilitation, Intermittent ClaudicationCreatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation Suplementação de creatina como potencial agente terapêutico na reabilitação da doença arterial obstrutiva periférica RESUMOSuplementação de Creatina (Cr) têm sido utilizada de forma segura e eficaz em diversas condições de saúde e doença, incluindo fraqueza, atrofia e distúrbios metabólicos musculares. Na Doença arterial obstrutiva periférica (DAOP), a isquemia crônica promove atrofia, denervação e prejuízos metabólicos musculares, reduzindo a força e resistência, prejudicando a aptidão física geral. Tomando em conjunto, os benefícios conhecidos da suplementação de Cr e a apresentação clínica da DAOP, apresentam a suplementação de Cr como potencial agente terapêutico a ser considerado. Objetivo: Realizar uma revisão sistemática da literatura científica procurando por estudos envolvendo a suplementação de Cr em portadores de DAOP, publicados nos últimos dez anos. Método: Uma pesquisa por artigos escritos em português e inglês no período descrito, incluindo o cruzamento de termos relacionados a DAOP e a suplementação de Cr foi realizada no PubMed, SciELO, e LILACS. Resultados: Um único estudo avaliou a influência da suplementação de Cr na amostra desejada (DAOP), de...

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“…9) In contrast, in Japan non-fatal stroke was highly prevalent in PAD patients compared to global patients. 10) Prevention of stroke is mandatory in the long-term treatment for the Japanese PAD patients. Improved medical care systems and social environment may account for the differences seen.…”

Section: Regional Differencesmentioning

confidence: 99%

“…Exercise conditioning, especially with supervised, structured regimens, increases pain-free and maximal walking time and distance, with average improvements of 134% to 179% for pain-free walking and 96% to 122% for maximal walking ability. [7][8][9][10] Only cilostazol is recommended for the treatment of PAD by TASC II and ACC/AHA Guidelines. However, drugs available for treatment in Asia are different from U.S. and Europe, and this needs to be taken into consideration in the pharmacotherapy of PAD.…”

Section: Two Goals For the Treatment Of Padmentioning

confidence: 99%

“…In clinical studies, beraprost has been shown to improve PAD with ischaemic ulceration, pain at rest or peripheral coldness and to effectively treat primary pulmonary hypertension. [9][10][11] Medical therapies for PAD aim to improve ischaemic symptoms, to improve patency for vascular reconstruction (including endovascular treatment) and to prevent systemic vascular events. Beraprost is one of the most commonly used of the many drugs currently available in Japan for the treatment of PAD.…”

Section: The Potential Role Of Beraprost Sodium In T2 Dmmentioning

confidence: 99%

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Third Asian PAD Workshop

2012

Annals of Vascular Diseases

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Exercise Training for Claudication

Cited by 456 publications

References 108 publications

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

Third Asian PAD Workshop

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