Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats

Cheng, Shiu-Min; Ho, Tsung‐Jung; Yang, Ai‐Lun; Chen, I-Ju; Kao, Chung-Lan; Wu, Fan-Ni; Lin, James A.; Kuo, Chia‐Hua; Ou, Hsiu‐Chung; Huang, Chih‐Yang; Lee, Shin-Da

doi:10.1016/j.ijcard.2012.01.031

Cited by 72 publications

(68 citation statements)

References 36 publications

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“…Furthermore, we also found that appropriate exercise training can enhance the PI3K-Akt pathway (Lee et al 2008;Huang et al 2012;Cheng et al 2013;Lee et al 2013). In FOXO3, the three sites phosphorylated by Akt are Thr32, Ser253, and Ser315.…”

Section: Introductionmentioning

confidence: 60%

“…These data suggest that exercise training, resveratrol treatment, and exercise training combined with resveratrol treatment can all be cardioprotective. Our previous report revealed an antihypertrophic effect in rat hearts from exercise training (Lee et al 2008;Huang et al 2012;Cheng et al 2013;Lee et al 2013). Indeed, the collagen accumulation in the exercise training rat hearts was not as severe as that in the control group (Figs.…”

Section: Discussionmentioning

confidence: 79%

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Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Lin

Wei³

et al. 2014

AGE

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Exercise training is considered a benefit to heart function, but the benefit in aging hearts remains unknown. Activation of the PI3K-Akt survival pathway and suppression of Fas/FADD/caspase-8 apoptotic signaling by exercise training in hearts from young subjects have been described in our previous studies. However, the mechanisms are still unclear and need to be explored in aging hearts. Thus, 18-month-old rats were used as a model and underwent swimming exercise training, resveratrol treatment (15 mg/kg/day), or exercise training with resveratrol treatment for 1 month. The results showed that heart function in each group improved. AGE (2014) 36:9705

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Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 79%

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Lin

Wei³

et al. 2014

AGE

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“…Bax to Bcl-2 and increasing the activity of caspase-3 (Cardin et al 2003;Cheng et al 2013;Sheng et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Telmisartan reduces atrial arrhythmia susceptibility through the regulation of RAS–ERK and PI3K–Akt–eNOS pathways in spontaneously hypertensive rats

Wang

Zhang

Chen

et al. 2015

Can. J. Physiol. Pharmacol.

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Telmisartan is an angiotensin II receptor blocker that displays unique PPAR-γ modulating activity. PPAR-γ agonists have been shown to decrease susceptibility to atrial fibrillation through their antioxidant and antiapoptotic effects. The aim of this study was to determine whether telmisartan would have a greater effect on susceptibility to atrial arrhythmia in a hypertensive rat model than valsartan, which is a traditional angiotensin II receptor blocker. In this study, spontaneously hypertensive rats were treated with 10 mg·(kg body mass)(-1)·d(-1) telmisartan (TEL group), 10 mg·(kg body mass)(-1)·d(-1) valsartan (VAL group), or vehicle (saline; SHR group) for 4 weeks. Age-matched Wistar-Kyoto rats (WKY) were used as normotensive controls. After 4 weeks of treatment, we performed echocardiographic assessment, electrophysiological analysis, histological evaluation, and Western blot analysis. Telmisartan decreased systolic blood pressure to a similar extent as valsartan. Relative to the WKY controls, atrial arrhythmia susceptibility was significantly increased in the SHR group, and was significantly decreased by both telmisartan and valsartan, albeit to a greater extent with telmisartan. Arrhythmogenic atrial remodeling, including enlargement of the left atrium, myocyte hypertrophy, interstitial fibrosis, and myocyte apoptosis, was observed in the SHR group, and was accompanied by activated RAS-ERK signaling and suppressed PI3K-Akt-eNOS signaling. The results suggest that telmisartan reduced susceptibility to atrial arrhythmia to a greater extent than valsartan, ameliorated atrial remodeling, and reversed imbalances in the RAS-ERK and PI3K-Akt-eNOS pathways.

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“…It is adjusted by the interaction between survival and apoptotic pathways, with change the balance between the two pathways determining cell fate [35]. The apoptotic pathway exhibits increased levels with a reduced survival pathway in heart disease [36]. Jiang et al [37] demonstrated that the numbers of apoptotic cells increased in the rats that were fed a high-fat diet for 12 and 16 weeks and fatty acids cause changess in death and survival pathways and eventually apoptosis [38,39]; EPA and DHA reduce the risk of breast cancer and modulates breast carcinogenesis through regulation of the apoptotic pathway prevention of breast cancer development [40].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer’s Diseased Mice Hearts

et al. 2018

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To investigate a high cholesterol diet in Alzheimer’s disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty acid profiles of clams by gas chromatography (GC). The results showed that treatment with clams for three months reduced Fas/L and Caspase-3 in the Meretrix lusoria and Geloina eros groups, but Fas-associated death domain (FADD) and Caspase-8 were strongly reduced in the Geloina eros group. For the mitochondria-dependent apoptotic pathway, the reduction of apoptosis proteins were observed in the hearts of clams-treated AD mice. BAK and Caspase-9 was reduced in the Meretrix lusoria group, but Caspase-3 and Cytochrome-c were reduced in Geloina eros group. Enhancement of survival proteins p-AKT, p-IGF1R, p-PI3K, Bcl-XL, Bcl2, and the longevity SIRT1 signaling proteins, p-AMPK-α, SIRT1, PGC1-α, p-FOXO3 were observed in clams-treated mice and even more strongly enhanced in the Meretrix lusoria, Geloina eros and Corbicula fluminea groups. This study observed that the ingestion of clams caused a reduction of apoptosis proteins and enhancement of survival and SIRT1 signaling proteins in the hearts.

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Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats

Cited by 72 publications

References 36 publications

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts

Telmisartan reduces atrial arrhythmia susceptibility through the regulation of RAS–ERK and PI3K–Akt–eNOS pathways in spontaneously hypertensive rats

The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer’s Diseased Mice Hearts

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