Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise

Smith, Joshua R.; Hirai, Daniel M.; Copp, Steven W.; Ferguson, Scott K.; Holdsworth, Clark; Hageman, K. Sue; Poole, David C.; Musch, Timothy I.

doi:10.1016/j.resp.2021.103710

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…CHF refers to any clinical syndrome of ventricular filling or impaired ejection ability caused by the abnormal cardiac structure or function [ 11 ]. Its clinical manifestations are exertional dyspnea, chest tiredness, fatigue, and other symptoms, accompanied by jugular vein anger, pulmonary circulation congestion, systemic circulation congestion, and surrounding tissue edema caused by cardiac structure and function abnormality [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of implantable cardioverter defibrillator/cardiac resynchronization therapy defibrillator (ICD/CRT-D) implantation on adverse events and the readmission rate in patients with chronic heart failure (CHF). Methods. Sixty patients with CHF treated in our hospital from April 2019 to July 2021 were enrolled. The patients were randomly assigned into the control group and study group. The control group received routine intervention, and the study group received remote management with ICD/CRT-D implantation. Results. First of all, we compared the general data of the two groups. There was no significant difference in LVEF, NYHA grade, concomitant disease, and history of arrhythmia ( P > 0.05 ). Secondly, we compared the end-point events. In the study group, 5 cases of heart failure were readmitted, 0 cases died, and 4 cases were admitted to hospital with arrhythmia and ICD events, with a total incidence of 30.0%, while in the control group, 12 cases were rehospitalized with heart failure, 3 cases died, 25 cases were admitted with arrhythmia and ICD events, and the total incidence rate was 56.67% ( P < 0.05 ). In terms of the readmission rate of patients with heart failure in grade NYHAII and grade III, among the patients with grade NYHAII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group ( P < 0.05 ). Among the patients with grade NYHAIII, the number of patients with heart failure less than once in the study group was higher compared to that in the control group and the number of patients with heart failure ≥ once in the study group was lower compared to that in the control group. There exhibited no significant difference in the data ( P > 0.05 ). Considering the occurrence of VT and VF events, the study team reported that 14 patients recorded a total of 276 ventricular arrhythmias: 261 ventricular tachycardia and 15 ventricular fibrillations. Among them, 24 VT (9.2%) and 4 VF (26.7%) were determined to be misrecognition of the equipment. A total of 178 ventricular arrhythmias were recorded in 13 patients in the control group, including 152 ventricular tachycardia and 26 ventricular fibrillations. Among them, 10 VT (6.6%) and 8 VF (30.8%) were determined as misrecognition of the device. In regard to the treatment results of the two groups, after admission to the hospital for radio frequency, ablation, and adjustment of drug treatment to reprogram control, the patients did not reappear to have CRT-D misidentification and misdischarged. Finally, we compared the diagnosis time of VT/VE events. The time from VT/VE events to diagnosis in 14 patients in the study group was 2.55 ± 1.41 days, and that in 13 patients in the control group was 37.32 ± 15.31 days. The discovery of ICD events in the study group was significantly earlier compared to that in the routine follow-up group ( P < 0.05 ). This gives doctors enough time to assess the patient’s condition and determine a further diagnosis and treatment plan. Conclusion. Using ICD/CRT-D implantation to remotely monitor patients with CHF, through remote monitoring of the 24-hour average heart rate and the heart rate at rest and patient activity and other parameters and early intervention, the readmission rate caused by the deterioration of heart failure can be reduced. Compared with routine follow-up, remote monitoring significantly reduced the diagnosis time of VT/VE events.

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Section: Discussionmentioning

confidence: 99%

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Liu

Xing

2022

Computational and Mathematical Methods in Medicine

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Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise

Butenas

Copp

Hageman

et al. 2023

Journal of Applied Physiology

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In rats with type 2 diabetes mellitus (T2DM) compared to non-diabetic healthy controls, muscle blood flow (Q̇m) to primarily glycolytic hindlimb muscles and the diaphragm muscle are elevated during submaximal treadmill running consequent to lower skeletal muscle mass, a finding that held even when muscle mass was normalized to body mass. In rats with heart failure with reduced ejection fraction (HF-rEF) compared to healthy controls, hindlimb Q̇m was lower, while diaphragm Q̇m is elevated during submaximal treadmill running. Importantly, T2DM is the most common co-morbidity present in HF-rEF patients, but the effect of concurrent T2DM and HF-rEF on limb and respiratory Q̇m during exercise is unknown. We hypothesized that during treadmill running (20 m·min-1; 10% incline) hindlimb and diaphragm Q̇m would be higher in T2DM Goto-Kakizaki rats with HF-rEF (i.e., HF-rEF+T2DM) compared to non-diabetic Wistar rats with HF-rEF. Ejection fractions were not different between groups (HF-rEF: 30±5; HF-rEF+T2DM: 28±8 %; P=0.617), whereas blood glucose was higher in HF-rEF+T2DM (209±150 mg/dL) compared with HF-rEF rats (113±28 mg/dL; P=0.040). Hindlimb muscle mass normalized to body mass was lower in rats with HF-rEF+T2DM (36.3±1.6 mg/g) compared to non-diabetic HF-rEF counterparts (40.3±2.7 mg/g; P<0.001). During exercise Q̇m was elevated in rats with HF-rEF+T2DM compared with non-diabetic counterparts to the hindlimb (HF-rEF: 100±28; HF-rEF+T2DM: 139±23 mL·min-1·100g-1; P<0.001) and diaphragm (HF-rEF: 177±66; HF-rEF+T2DM: 215±93 mL·min-1·100g-1; P=0.035). These data suggest that the pathophysiological consequences of T2DM on hindlimb and diaphragm Q̇m during treadmill running in the GK rat persist even in the presence of HF-rEF.

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Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise

Cited by 2 publications

References 34 publications

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Effect of ICD/CRT-D Implantation on Adverse Events and Readmission Rate in Patients with Chronic Heart Failure (CHF)

Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise

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