Exercise training attenuates insulin resistance and improves β-cell function in patients with systemic autoimmune myopathies: a pilot study

The effect of a 24-week training focused on activities of daily living, muscle strengthening, and stability in idiopathic inflammatory myopathies: a monocentric controlled study with follow-up

“…However, after applying a modified version of the 2016 ACR/EULAR response criteria [ 35 ] using the remaining three core set measures (MMT-8, HAQ, and CK), we demonstrated a moderate improvement over weeks 0–24 in the IG. In line with our findings of improvement in MMT-8, outcome measures assessing muscle strength improved to a different extent also in other mentioned studies, including MMT-8 in [ 37 , 40 ], voluntary repetition maximum (VRM) in [ 40 , 41 ], peak isometric torque (PIT) in [ 41 , 48 ], leg press and/or leg extension and/or bench press in [ 42 , 43 , 51 ], or dynamometry of both distal and proximal muscles in [ 45 ]. Contrary to our study, no improvement in muscle strength was found according to MMT-8 in [ 39 , 44 , 49 , 51 ], MMT on a scale from 0 to 20 in [ 48 ], or PIT in [ 50 ].…”

“…In line with our findings of improvement in MMT-8, outcome measures assessing muscle strength improved to a different extent also in other mentioned studies, including MMT-8 in [ 37 , 40 ], voluntary repetition maximum (VRM) in [ 40 , 41 ], peak isometric torque (PIT) in [ 41 , 48 ], leg press and/or leg extension and/or bench press in [ 42 , 43 , 51 ], or dynamometry of both distal and proximal muscles in [ 45 ]. Contrary to our study, no improvement in muscle strength was found according to MMT-8 in [ 39 , 44 , 49 , 51 ], MMT on a scale from 0 to 20 in [ 48 ], or PIT in [ 50 ]. Similar to our findings, muscle endurance improved to a varying extent in four studies by Alexanderson et al, assessing FI-2 with improvement only in shoulder flexion in [ 44 ] or FI in [ 38 , 46 , 47 ].…”

“…We employed several traditional primary (MMT-8, FI-2) and secondary (e.g., HAQ, SF-36, systemic measures of disease activity, Borg CR-10) outcomes, included some less frequently used ones (e.g., local measures of inflammation, fatigue, and depression), and investigated three new exploratory parameters derived from our preliminary data (i.e., stability, basal metabolism, and muscle fitness). In contrast to our approach, four [ 39 , 40 , 44 , 51 ] out of 15 above-mentioned studies used the IMACS preliminary definitions of improvement with six core set measures [ 36 ]. Interestingly, three studies have demonstrated improvement according to IMACS response criteria in 6/9 [ 39 ], 7/11 [ 40 ], and 2/9 patients [ 44 ], even though none of these studies demonstrated any significant improvement in individually assessed MMT-8 or HAQ on a group level [ 39 , 40 , 44 ] with the exception of an improvement in MMT-8 in one study [ 40 ].…”

Systematic review of physical exercise for patients with idiopathic inflammatory myopathies

“…Three studies analyzed patients with juvenile DM (JDM; Habers et al, 2016; Omori et al, 2012; Riisager, Mathiesen, Vissing, Preisler, & Ørngreen, 2013), while the others analyzed adults with IIM. Eleven studies examined patients with either PM or DM (Alemo Munters, Dastmalchi, Andgren, et al, 2013; Alemo Munters, Dastmalchi, Katz, et al, 2013; Alexanderson et al, 2014; Alexanderson, Dastmalchi, Esbjörnsson‐Liljedahl, Opava, & Lundberg, 2007; Alexanderson, Stenström, Jenner, & Lundberg, 2000; Alexanderson, Stenström, & Lundberg, 1999; de Oliveira et al, 2019; Mattar, Gualano, Perandini, et al, 2014; Regardt et al, 2014; Wiesinger, Quittan, Aringer, et al, 1998; Wiesinger, Quittan, Graninger, et al, 1998), while six studies examined patients with IBM (Arnardottir, Alexanderson, Lundberg, & Borg, 2003; Johnson et al, 2009; Johnson, Edwards, Walters, Thickbroom, & Mastaglia, 2007; Jørgensen, Aagaard, Frandsen, Boyle, & Diederichsen, 2018; Spector et al, 1997; Wallace et al, 2019), and one study examined patients with PM (Tiffreau et al, 2017). Most study patients were in a chronic or stable disease phase.…”

Treinamento físico aeróbio e prevenção da doença hepática gordurosa não alcoólica: papel da lipogênese e do estresse de retículo no fígado

“…Nos estudos com administração exógena de FGF21, foram observadas melhoras na tolerância à glicose e na sensibilidade à insulina em roedores e macacos diabéticos (COSKUN et al, 2008;XU et al, 2009;WU et al, 2011;FOLTZ et al, 2012) (VAN et al, 2010;DA LUZ et al, 2011;OLIVEIRA et al, 2011;BRADLEY et al, 2018). Além disso, o TFA promove aumento da sensibilidade à insulina e melhora da glicemia em seres humanos (ZIERATH, 2002;FROSIG et al, 2007;DE OLIVEIRA et al, 2019). SRIWIJITKAMOL et al (2006) em Tris-aminometano (50 mM), EDTA (1mM) e DTNB (0,2 mM), pH=8,1.…”