Exercise training and cardiac autonomic function in type 2 diabetes mellitus: A systematic review

Bhati, Pooja; Shenoy, Shweta; Hussain, M. Ejaz

doi:10.1016/j.dsx.2017.08.015

Cited by 64 publications

(67 citation statements)

References 53 publications

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“…Recent meta-analysis on the effects of exercise (supervised, or unsupervised and of variable intensities) increased HRV measures in individuals with various cardiovascular diseases and diabetes imply that the postexercise state is associated with increased vagal modulation and decreased sympathetic tone. These findings have also been shown by Pearson et al [ 11 ] and others for heart failure subjects [ 22 , 23 ] and those with diabetes and metabolic syndrome [ 12 , 24 , 25 ]. The beneficial effects of improving HRV in subjects with reduced HRV such as heart failure, diabetes, and the frail elderly has been shown by others [ 12 , 24 – 26 ].…”

Section: Discussionsupporting

confidence: 79%

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

Adams

Patel

López³

et al. 2018

Journal of Sports Medicine

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Background Heart rate variability (HRV) reflects neural balance between sympathetic and parasympathetic autonomic nervous systems (ANS). Reduced HRV occurs in several chronic diseases and physical inactivity. External addition of pulses to the circulation restores HRV. A new method to add pulses to the circulation can be accomplished with a passive simulated jogging device (JD). We hypothesized that application of JD might increase HRV in seated and supine postures in a heterogeneous group of volunteer subjects. Methods Twenty ambulatory persons (age range 31-88) were recruited. The physical activity intervention (JD) moved the feet in a repetitive and alternating manner; upward movement of the pedal is followed by a downward movement of the forefoot tapping against a semirigid bumper to simulate tapping of feet against the ground during jogging. Each subject underwent four, 30 min sessions in seated and supine postures with the active JD and same with Sham. HRV was assessed at baseline (BL), and Recovery (REC) from analysis of an electrocardiogram. Time domain variables were computed, namely, standard deviation of all normal RR intervals (SDNN) and square root of the mean of the sum of the squares of differences between adjacent RR intervals (RMSSD). Frequency domain measures were determined using a standard Fast Fourier spectral analysis, as well as parameters of Poincaré plots. Results Thirty minutes of JD significantly increased time domain measures and Poincaré parameters of HRV in both seated and supine postures. Frequency domain parameters showed no change. The effects of JD on HRV measures were not affected by age, gender, or posture. Conclusion The passive simulated jogging device increased HRV in both seated and supine postures. This intervention that provided effortless physical activity is a novel method to harness the beneficial effects of increasing HRV.

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Section: Discussionsupporting

confidence: 79%

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

Adams

Patel

López³

et al. 2018

Journal of Sports Medicine

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“…Exercise is essential to maintain overall human health. Regular exercise is useful in the management of T2DM by mitigating the risk factors of associated comorbidities, including cardiovascular disease [32,39,121]. More importantly, exercise is a non-pharmacological intervention that can improve the outcome in patients with DCM by regulating cardiac mitochondrial metabolism, alleviating oxidative stress damage, and improving myocardial fibrosis, apoptosis, and vascular disorders [10,11].…”

Section: Resultsmentioning

confidence: 99%

“…If biomarkers or non-invasive imaging modalities could be used for early identification of high-risk patients [48,118], it would be feasible to prescribe personalized exercise program based on risk stratification. Since exercise may not only mitigate cardiac dysfunction but also improve the outcome of T2DM [32,112,[119][120][121], a therapeutic approach with a tailored exercise prescription would positively impact DCM management in the future. To this end, the development of tools for early diagnosis and optimization of risk stratification models would be pivotal, and in conjunction with well-designed clinical trials could provide the evidence to facilitate timely implementation.…”

Section: Clinical Perspective On the Future Use Of Exercise In Dcm Prmentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

Preprint

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Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising from diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include the prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function, and calcium regulation. The present review summarizes the recent findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

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“…Exercise is essential to maintain overall human health. Regular exercise is useful in the management of T2DM by mitigating the risk factors of associated comorbidities, including cardiovascular disease [36,43,143]. More importantly, exercise is a non-pharmacological intervention that can improve the outcome in patients with DCM by regulating cardiac mitochondrial metabolism, alleviating oxidative stress damage, and improving myocardial fibrosis, apoptosis, and vascular disorders [10,11].…”

Section: Discussionmentioning

confidence: 99%

“…If biomarkers or non-invasive imaging modalities could be used for early identification of high-risk patients [46,140], it would be feasible to prescribe personalized exercise programs based on risk stratification. Since exercise may not only mitigate cardiac dysfunction but also improve the outcome of T2DM [36,134,[141][142][143], a therapeutic approach with a tailored exercise prescription would positively impact DCM management in the future. To this end, the development of tools for early diagnosis and optimization of risk stratification models would be pivotal and in conjunction with well-designed clinical trials could provide the evidence to facilitate timely implementation.…”

Section: Exercise Is An Early Diagnostic Tool For Prevention and Bettmentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

IJMS

View full text Add to dashboard Cite

Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

show abstract

Exercise training and cardiac autonomic function in type 2 diabetes mellitus: A systematic review

Cited by 64 publications

References 53 publications

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

The Effects of Passive Simulated Jogging on Short-Term Heart Rate Variability in a Heterogeneous Group of Human Subjects

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

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