Abstract:The physiological changes observed in skeletal muscle following exercise training may be due to epigenetic modifications. Previously, we have shown increased methylation of cytosines (5.0 to 24.4%) in sorbin and SH3 domain containing 3 (SORBS3) in obesity. In another study, we showed decreased methylation (-5.6 to -24.2%) of SORBS3 following weight loss induced by bariatric surgery. The aim of this study was to determine whether an exercise training regimen alters DNA methylation of SORBS3. Skeletal muscle bio… Show more
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