Exercise through a cardiac rehabilitation program attenuates oxidative stress in patients submitted to coronary artery bypass grafting

Zau, José Francisco Taty; Zeferino, Rodrigo C.; Mota, Nádia S.R.S.; Martins, Gerez Fernandes; Serra, Salvador Manoel; Cunha, Therezil Bonates da; Lima, D.; Pereira, Basílio de Bragança; Nascimento, Emília Matos do; Filho, Danilo Wilhelm; Pedrosa, Rozangela Curi; Pedrosa, Roberto Coury

doi:10.1080/13510002.2017.1418191

Cited by 7 publications

(4 citation statements)

References 33 publications

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“…It was shown that lipid and protein oxidation in erythrocyte membrane leads to an increase in their mobility [ 41 ]. The results of our study are consistent with those of Taty Zau et al [ 42 ], which demonstrate a decrease in thiobarbituric acid reactive substances (TBARSs) and carbonyl levels after CCR. It seems that changes in lipid fluidity are rather associated with alterations in protein-lipid interaction.…”

Section: Discussionsupporting

confidence: 93%

“…Generally, CCR attenuates oxidative stress in CAD patients [ 42 ]. It has been established in this study that the rehabilitation training led to a reduction in oxidative stress indicators such as malonyldialdehyde and carbonyl compounds, as well as an increase in total antioxidant capacity including glutathione in patients after CCR [ 42 ]. Additionally, an increase in the enzyme activities of antioxidants such as SOD-1, GSH-Px, and catalase was demonstrated [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

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Alterations in the Properties of Red Blood Cells in Men with Coronary Artery Diseases after Comprehensive Cardiac Rehabilitation

Gwoździński

Pieniążek

Bernasińska-Słomczewska

et al. 2020

Cardiology Research and Practice

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Purpose. Comprehensive cardiac rehabilitation (CCR) is a complex program aimed at improving the health status of patients with coronary artery disease (CAD), especially those who have been subjected to cardiac interventions (PCI and CABG).The aim of this study was to measure the changes in the properties of red blood cells (RBCs) in men with CAD after cardiac intervention and after participation in CCR program. Methods. In this study, we have investigated the influence of the physical training-based CCR program in 12 men with CAD, after PCI or CABG. The characteristics of RBCs including the basic morphology of RBCs, the conformational state of RBC membrane protein and hemoglobin, acetylcholinesterase activity, membrane fluidity, the osmotic fragility, and thiol concentration in membrane and in hemolysate were measured. Ascorbate concentration and reduced glutathione were also determined. The analysis was performed in men, before and after participation in CCR. The properties of RBCs were observed in connection with the exercise test, and parameters were evaluated before, immediately after, and 1 hour after the exercise test. Results. After CCR, a decrease in the mobility of erythrocyte membrane proteins was observed, which was accompanied by a decrease in lipid fluidity. In addition, immediately after the exercise test and 1 hour later, we measured a decrease in thiol level in hemolysate, but not in the plasma membrane. Unexpectedly, an increase in reduced glutathione concentration one hour after the exercise test after completing comprehensive cardiac rehabilitation was observed. Conclusion. CCR in men with CAD after cardiac intervention is connected with decreased membrane fluidity and decreased membrane protein mobility, which indicates that reduction of oxidative changes in these components occurs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Alterations in the Properties of Red Blood Cells in Men with Coronary Artery Diseases after Comprehensive Cardiac Rehabilitation

Gwoździński

Pieniążek

Bernasińska-Słomczewska

et al. 2020

Cardiology Research and Practice

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“…Instead, a higher CVR to an acute bout of exercise could be due to the influence of physical activity and walking on vascular health by reducing oxidative stress and increasing vasomotor reactivity. [28][29][30][31] Previous work reported that an 8-week physical activity intervention during subacute stroke reduced oxidative stress 32 and a 6-month walking intervention in chronic stroke increased the ability of the cerebrovascular system to vasodilate and vasoconstrict. 31 Our previous work has shown that self-reported physical activity at 3 and 6 months poststroke was associated with a greater CVR than those reporting low physical activity levels.…”

Section: Cerebrovascular Responsementioning

confidence: 99%

Secondary Analysis of Walking Activities During the Acute Stroke Hospital Stay and Cerebrovascular Health

Whitaker¹,

Henry²,

Morton³

et al. 2022

Cardiopulm Phys Ther J

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Purpose:Physical activity within the hospital poststroke is recommended for cardiovascular and musculoskeletal health, but no studies have examined cerebrovascular health. We hypothesized that individuals who walked farther distances (FARhigh) during the acute phase of stroke recovery in a hospital setting would have a higher resting middle cerebral artery blood velocity (MCAv) and a greater cerebrovascular response (CVR) to moderate-intensity exercise at 3 months poststroke, compared with individuals who walked shorter distances (FARlow).Methods:At 3 months poststroke, we recorded 90 seconds of resting baseline (BL) MCAv, followed by 6 minutes of moderate-intensity exercise. We calculated CVR as the change in MCAv from BL to steady-state exercise. We retrospectively collected the farthest distance walked within the hospital poststroke from the electronic medical record. Participants were classified as FARhigh or FARlow based on the average farthest walking distance.Results:Twenty participants completed the study, aged 63 (15) years. Baseline MCAv was not different between groups (P = .07). In comparison with FARlow, we report a higher CVR in FARhigh's ipsilesional ( truex¯ = 7.38 [5.42] vs truex¯ = 2.19 [3.53], P = .02)and contralesional hemispheres ( truex¯ = 8.15 [6.37] vs truex¯ = 2.06 [4.76], P = .04).Conclusions:Physical activity during the hospital stay poststroke may support cerebrovascular health after discharge. Prospective studies are needed to support this finding.

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“…Several studies have shown the utility of exercise training and cardiac rehabilitation in the management of HF and coronary artery disease. 63 64 65 Cardiac rehabilitation was designed to formulate exercise training for postmyocardial infarction patients to help with recovery and self-care. 66 The United States Center for Medicare Services recently decided to extend cardiac rehabilitation coverage to HFrEF patients as several studies showed the benefits of exercise training to improve HFrEF clinical outcomes.…”

Section: Managementmentioning

confidence: 99%

Pathophysiology and Management of Heart Failure in the Elderly

et al. 2022

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The population of elderly adults is increasing globally. It has been projected that the population of adults aged 65 years will increase by approximately 80% by 2050 in the United States. Similarly, the elderly population is rising in other countries; a notable example being Japan where approximately 30% of the population are aged above 65 years. The pathophysiology and management of heart failure (HF) in this age group tend to have more intricacies than in younger age groups owing to the presence of multiple comorbidities. The normal aging biology includes progressive disruption at cellular and genetic levels and changes in molecular signaling and mechanical activities that contribute to myocardial abnormalities. Older adults with HF secondary to ischemic or valvular heart disease may benefit from surgical therapy, valve replacement or repair for valvular heart disease and coronary artery bypass grafting for coronary artery disease. While referring these patients for surgery, patient and family expectations and life expectations should be taken into account. In this review, we will cover the pathophysiology and the management of HF in the elderly, specifically discussing important geriatric domains such as frailty, cognitive impairment, delirium, polypharmacy, and multimorbidity.

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Exercise through a cardiac rehabilitation program attenuates oxidative stress in patients submitted to coronary artery bypass grafting

Abstract: The results suggest that regular exercise through a cardiac rehabilitation program can attenuate oxidative stress in chronic coronary artery disease patients submitted to coronary artery bypass grafting.

Cited by 7 publications

References 33 publications

Alterations in the Properties of Red Blood Cells in Men with Coronary Artery Diseases after Comprehensive Cardiac Rehabilitation

Alterations in the Properties of Red Blood Cells in Men with Coronary Artery Diseases after Comprehensive Cardiac Rehabilitation

Secondary Analysis of Walking Activities During the Acute Stroke Hospital Stay and Cerebrovascular Health

Pathophysiology and Management of Heart Failure in the Elderly

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