Exercise Testing in Individuals with Morbid Obesity

Fornitano, Luis Domingos; Godoy, Moacir Fernandes de

doi:10.1007/s11695-008-9692-7

Cited by 15 publications

(5 citation statements)

References 38 publications

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“…Finally, previous reports indicate that measurements of VO 2 max among individuals with extreme obesity (BMI>40) are less precise due to distinct hemodynamic parameters in this population (Fornitano and Godoy, 2010). Thus, we elected to exclude from our study individuals with such extreme obesity levels.…”

Section: Discussionmentioning

confidence: 87%

Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning

Kimhy

Vakhrusheva

Bartels

et al. 2014

Psychiatry Research

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Previous reports indicate that among healthy individuals low Aerobic Fitness (AF) and high Body-Mass Index (BMI) predict poor neurocognition and daily-functioning. It is unknown whether these associations extend to disorders characterized by poor neurocognition, such as schizophrenia. Therefore, we compared AF and BMI in individuals with schizophrenia and non-clinical controls, and then within the schizophrenia group we examined the links between AF, BMI, neurocognition and daily-functioning. Thirty-two individuals with schizophrenia and 64 gender- and age-matched controls completed assessments of AF (indexed by VO2max) and BMI. The former also completed measures of neurocognition, daily-functioning and physical activity. The schizophrenia group displayed significantly lower AF and higher BMI. In the schizophrenia group, AF was significantly correlated with overall neurocognition (r=0.57), along with executive functioning, working memory, social cognition, and processing speed. A hierarchical regression analysis indicated that AF accounted for 22% of the neurocognition variance. Furthermore, AF was significantly correlated with overall daily-functioning (r=0.46). In contrast, BMI displayed significant inverse correlations with neurocognition, but no associations to daily-functioning. AF was significantly correlated physical activity. The authors discuss the potential use of AF-enhancing interventions to improve neurocognitive and daily-functioning in schizophrenia, along with putative neurobiological mechanisms underlying these links, including Brain-Derived Neurotrophic Factor.

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Section: Discussionmentioning

confidence: 87%

Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning

Kimhy

Vakhrusheva

Bartels

et al. 2014

Psychiatry Research

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“…It is also possible that the surrogate measures of insulin resistance used (fasting insulin and HOMA2) may not have been sensitive enough to assess insulin resistance in the small groups and more sensitive measures, such as hyperinsulinemic‐euglycemic clamp or insulin tolerance tests may have been more informative. Alternatively, the presence of obesity may have influenced the performance of the treadmill test 44,45 and the higher BMI in both the control and PCOS groups may have suppressed any differences that were observed in previous studies at a lower BMI 22 . Further research investigating lean women with PCOS may assist in clarifying the effect of obesity.…”

Section: Discussionmentioning

confidence: 96%

Comparison of aerobic exercise capacity and muscle strength in overweight women with and without polycystic ovary syndrome

Thomson

Buckley

Moran

et al. 2009

BJOG

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Objective To assess maximal aerobic capacity ( _ VO 2max ) and muscle strength in overweight and obese women with polycystic ovary syndrome (PCOS) and determine their relationship with metabolic and hormonal factors.Design Cross-sectional study.Setting Clinical Research Unit.Population Overweight and obese women with PCOS (n = 10) and age-and weight-matched healthy controls (n = 16).Methods _ VO 2max was measured during an incremental treadmill test and maximal isometric (ImS) and isokinetic knee extensor strength (IkS) (120°/second) were assessed by isokinetic dynamometry.Main outcome measures _ VO 2max , ImS, IkS, waist circumference, blood lipids, glucose, insulin, insulin resistance (homeostatic model assessment [HOMA2]), C-reactive protein (CRP), hormonal profile.Results PCOS women had higher levels of testosterone and free testosterone (P £ 0.05), but there were no significant differences in any cardiovascular disease (CVD) risk markers between the groups. _ VO 2max was similar in women with PCOS and healthy controls (PCOS 26.0 ± 4.1 ml/kg/minute, controls 25.7 ± 3.8 ml/ kg/minute; P = 0.90), as was ImS (PCOS 1.50 ± 0.54 Nm/kg, controls 1.50 ± 0.47 Nm/kg; P = 0.96) and IkS (PCOS 1.04 ± 0.32 Nm/kg, controls 1.16 ± 0.23 Nm/kg; P = 0.32). _ VO 2max was inversely related to waist circumference, insulin, HOMA2 and CRP. Waist circumference was inversely associated with ImS and IkS. No significant associations between exercise parameters and hormonal variables were identified.Conclusions Compared to age-and weight-matched healthy overweight and obese women with similar insulin resistance and CVD risk profiles, women with PCOS had similar aerobic capacity and muscle strength. This suggests PCOS, at least in the absence of an adverse metabolic profile is unlikely to limit physical function. Larger studies examining the effects of PCOS on exercise tolerance in a diverse range of PCOS phenotypes is required.

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“…Gondoni et al 19 compared the HR response to progressive exercise in obese and lean individuals and reported that obese subjects had a blunted HR response and a reduced associated exercise tolerance. Fornitano et al 20 noted differing clinical, electrocardiographic and hemodynamic responses to conventional exercise testing in morbidly obese individuals versus their overweight counterparts, reinforcing the notion that body composition should be considered when evaluating exercise performance.…”

Section: Discussionmentioning

confidence: 99%

Influence of central obesity in estimating maximal oxygen uptake

Silva

Franklin

Araújo

2016

Clinics

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OBJECTIVE:To assess the influence of central obesity on the magnitude of the error of estimate of maximal oxygen uptake in maximal cycling exercise testing.METHOD:A total of 1,715 adults (68% men) between 18-91 years of age underwent cardiopulmonary exercise testing using a progressive protocol to volitional fatigue. Subjects were stratified by central obesity into three quartile ranges: Q1, Q2-3 and Q4. Maximal oxygen uptake [mL.(kg.min)-1] was estimated by the attained maximal workload and body weight using gender- and population-specific equations. The error of estimate [mL.(kg.min)-1] and percent error between measured and estimated maximal oxygen uptake values were compared among obesity quartile ranges.RESULTS:The error of estimate and percent error differed (mean ± SD) for men (Q1=1.3±3.7 and 2.0±10.4; Q2-3=0.5±3.1 and -0.5±13.0; and Q4=-0.3±2.8 and -4.5±15.8 (p<0.05)) and for women (Q1=1.6±3.3 and 3.6±10.2; Q2-3=0.4±2.7 and -0.4±11.8; and Q4=-0.9±2.3 and -10.0±22.7 (p<0.05)).CONCLUSION:Central obesity directly influences the magnitude of the error of estimate of maximal oxygen uptake and should be considered when direct expired gas analysis is unavailable.

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Exercise Testing in Individuals with Morbid Obesity

Cited by 15 publications

References 38 publications

Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning

Aerobic fitness and body mass index in individuals with schizophrenia: Implications for neurocognition and daily functioning

Comparison of aerobic exercise capacity and muscle strength in overweight women with and without polycystic ovary syndrome

Influence of central obesity in estimating maximal oxygen uptake

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