Exercise right heart catheterization for pulmonary hypertension identified on screening echocardiography in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort
Abstract:Pulmonary hypertension, determined non-invasively by tricuspid regurgitant jet velocity on Doppler echocardiography, was previously identified in 25% of long-term survivors who received chest-directed radiotherapy. To validate non-invasively defined pulmonary hypertension ten survivors (mean age 48 years), exposed to chest radiotherapy underwent right heart catheterization with planned cardiopulmonary exercise testing during catheterization. Eight participants had an elevated mean pulmonary artery pressure at … Show more
“…
BMI body mass index
BPS Biplane Simpson’s method
BSA body surface area
E mitral inflow velocity
E′ mitral annulus tissue Doppler velocity
LVEF left ventricular ejection fraction
LVOT left ventricular outflow tract
RVFAC right-ventricular fractional area change
SV stroke volume
VTI velocity-time integral (method)
*
participant ID numbers from the prior study (8) are maintained here
…”
Section: Figurementioning
confidence: 99%
“…
CI cardiac index (Fick method)
mPAP mean pulmonary arterial pressure
MvO2 mixed venous oxygen saturation
PAWP pulmonary arterial wedge pressure
PVR pulmonary vascular resistance
RAP right atrial pressure
WU Wood Units
*
participant ID numbers from the prior study (8) are maintained here
†
thermodilution method
…”
Section: Figurementioning
confidence: 99%
“…
HR heart rate
PBV pulmonary blood volume
PTT pulmonary transit time
rPBV pulmonary blood volume relative to stroke volume
TTE-CCL interval between echocardiogram and cardiac catheterization
*
participant ID numbers from the prior study (8) are maintained here
…”
Section: Figurementioning
confidence: 99%
“…The study population consisted of adult survivors of childhood cancer exposed to chest radiation (St Jude Lifetime Cohort) who underwent comprehensive right-heart catheterization at our institution as part of a definitive evaluation for pulmonary hypertension. 8 (1) The study protocol called for those individuals to undergo a standard TTE with echocardiographic contrast on the same day, prior to the catheterization procedure.…”
Section: Study Populationmentioning
confidence: 99%
“…Demographic characteristics, anthropomorphic measurements, and medical history were abstracted from the electronic medical record. For consistency, the participant ID numbers from the prior study 8 are maintained (Tables 1-3).…”
Relative PBV derived from contrast echocardiography correlates with PAWP. If validated in larger studies, rPBV could potentially be used as an alternative to invasively determine left-sided filling pressure.
“…
BMI body mass index
BPS Biplane Simpson’s method
BSA body surface area
E mitral inflow velocity
E′ mitral annulus tissue Doppler velocity
LVEF left ventricular ejection fraction
LVOT left ventricular outflow tract
RVFAC right-ventricular fractional area change
SV stroke volume
VTI velocity-time integral (method)
*
participant ID numbers from the prior study (8) are maintained here
…”
Section: Figurementioning
confidence: 99%
“…
CI cardiac index (Fick method)
mPAP mean pulmonary arterial pressure
MvO2 mixed venous oxygen saturation
PAWP pulmonary arterial wedge pressure
PVR pulmonary vascular resistance
RAP right atrial pressure
WU Wood Units
*
participant ID numbers from the prior study (8) are maintained here
†
thermodilution method
…”
Section: Figurementioning
confidence: 99%
“…
HR heart rate
PBV pulmonary blood volume
PTT pulmonary transit time
rPBV pulmonary blood volume relative to stroke volume
TTE-CCL interval between echocardiogram and cardiac catheterization
*
participant ID numbers from the prior study (8) are maintained here
…”
Section: Figurementioning
confidence: 99%
“…The study population consisted of adult survivors of childhood cancer exposed to chest radiation (St Jude Lifetime Cohort) who underwent comprehensive right-heart catheterization at our institution as part of a definitive evaluation for pulmonary hypertension. 8 (1) The study protocol called for those individuals to undergo a standard TTE with echocardiographic contrast on the same day, prior to the catheterization procedure.…”
Section: Study Populationmentioning
confidence: 99%
“…Demographic characteristics, anthropomorphic measurements, and medical history were abstracted from the electronic medical record. For consistency, the participant ID numbers from the prior study 8 are maintained (Tables 1-3).…”
Relative PBV derived from contrast echocardiography correlates with PAWP. If validated in larger studies, rPBV could potentially be used as an alternative to invasively determine left-sided filling pressure.
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