Exercise rescues cognitive deterioration in naturally aged rats via PGC1α/FNDC5/irisin/AMPK signaling pathway to restore redox, endothelial, and neuronal homeostasis
Marwa Muhammad,
Nashwa Ahmed,
Noha El-shaer
Abstract:Background: Aging-associated cognitive impairments become a global phenomenon, especially with the increase in life expectancy and sedentary lifestyle. Thus, the present study aimed to assess the cognitive functions in aged rats and explore the potential involvement of the endogenous exercise-induced myokine irisin in such an effect. Lastly, it was to identify the possible irisin downstream adenosine monophosphate-activated protein kinase (AMPK) signaling pathway to restore hippocampal redox and eNOS/NO/brain-… Show more
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