Exercise-related Potassium and Free Fatty Acid Level Changes in Coronary Artery Disease

MacGowan, Guy A.; Casey, Michael; Stirling, Robert; Brett, Mark; Kinsella, Anthony; Horgan, John

doi:10.1378/chest.103.3.728

Cited by 2 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While this study was in younger subjects, the metabolic re sponses were identical to those in healthy middle-aged subjects [2], We have also pre viously demonstrated identical responses in patients with coronary artery disease un dergoing treadmill exercise [14].…”

Section: Discussionsupporting

confidence: 65%

Fluid Replacements after Squash: An Analysis of the Effects of Several Fluid Regimens on Exercise-Related Metabolic Changes

MacGowan¹,

Ryan²,

O'Donovan³

et al. 1994

Cardiology

View full text Add to dashboard Cite

We studied the effects of several fluid replacements taken after squash on exercise-related metabolic responses. 12 subjects played 5 games and after each game were assigned one of the following, receiving a different one each time: (1) no fluid replacement, or 500 ml of (2) water, (3) electrolyte solution, (4) glucose solution or (5) a glucose/electrolyte ‘sports’ drink. Circulating levels of lactate, free fatty acids, glucose, potassium, sodium and plasma osmolality were measured at rest and at 5,15, 30 and 60 min after games. There were significant changes over time for all measured variables (p < 0.001). The only effect of these drinks was by the glucose-containing drinks, which resulted in significant elevation of blood glucose levels (p < 0.001); no effects on circulating electrolyte levels were demonstrated. In conclusion, while fluid replacements may increase glucose levels, electrolyte levels are not affected by drinks which are commonly used after squash.

show abstract

Section: Discussionsupporting

confidence: 65%

Fluid Replacements after Squash: An Analysis of the Effects of Several Fluid Regimens on Exercise-Related Metabolic Changes

MacGowan¹,

Ryan²,

O'Donovan³

et al. 1994

Cardiology

View full text Add to dashboard Cite

show abstract

Untitled

Wolff

Rotmensch

Stanley

et al. 2002

Heart Failure Reviews

View full text Add to dashboard Cite

This review article discusses pharmacological approaches to optimizing myocardial metabolism during ischemia. Fatty acids are the main fuel for the healthy heart, with a lesser contribution coming from the oxidation of glucose and lactate. Myocardial ischaemia dramatically alters fuel metabolism, causing an accelerated rate of glucose conversion to lactate and a switch from lactate uptake by the heart to lactate production. This causes a dramatic disruption in cell homeostasis (e.g. lactate accumulation and a decrease in pH and ATP). Paradoxically, moderately ischemic tissue (approximately 50% of normal flow) continues to derive most of its energy (50-70%) from the oxidation of fatty acids despite a high rate of lactate production. This ischaemia-induced disruption in cardiac metabolism can be minimized by metabolic agents that reduce fatty acid oxidation and increase the combustion of glucose and lactate, resulting in clinical benefit to the ischemic patient. Agents that inhibit fatty acid beta-oxidation, such as ranolazine and trimetazidine, have proven to be effective in the treatment of stable angina. Treatment of acute myocardial infarction patients with an infusion of the glucose-insulin-potassium, which results in suppression of myocardial fatty acid oxidation and greater glucose combustion, has proven effective in reducing mortality. These metabolic therapies are free of direct hemodynamic or chronotropic effects, and thus are well positioned for use alongside traditional agents such as beta-adrenergic receptor antagonists or calcium channel antagonists.

show abstract

Exercise-related Potassium and Free Fatty Acid Level Changes in Coronary Artery Disease

Cited by 2 publications

References 31 publications

Fluid Replacements after Squash: An Analysis of the Effects of Several Fluid Regimens on Exercise-Related Metabolic Changes

Fluid Replacements after Squash: An Analysis of the Effects of Several Fluid Regimens on Exercise-Related Metabolic Changes

Untitled

Contact Info

Product

Resources

About