Exercise rehabilitation of pediatric patients with cardiovascular disease

Miller, Tracie L.; Horgan, Sara; Lipshultz, Steven E.

doi:10.1016/j.ppedcard.2004.12.002

Cited by 28 publications

(28 citation statements)

References 78 publications

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“…[613][614][615][616] Abnormal exercise responses, including lack of endurance, cardiac rhythm disturbances, and ischemic changes have been reported in 43% of survivors receiving anthracyclines before 1991. 185 Single-site studies 613 and meta-analyses 615 show that survivors of childhood leukemia have an aerobic capacity 13% lower than that of age-and sex-matched control subjects.…”

Section: Exercise Capacity and Physical Activity Interventionsmentioning

confidence: 99%

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

Lipshultz¹,

Adams²,

Colan³

et al. 2013

Circulation

Self Cite

494

436

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Section: Exercise Capacity and Physical Activity Interventionsmentioning

confidence: 99%

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

Lipshultz¹,

Adams²,

Colan³

et al. 2013

Circulation

Self Cite

494

436

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“…Aerobic exercise may also be helpful, although patients should be tested to ensure a stable cardiovascular function before starting a physical activity [108]. A 12 weeks, hospital based physical activity program reduces body fat and improves general clinical conditions.…”

Section: Treatmentmentioning

confidence: 99%

“…A 12 weeks, hospital based physical activity program reduces body fat and improves general clinical conditions. Importantly, physical activity may be beneficial in some cancer survivors but harmful in others [108]. Beside these studies, it is our opinion that aerobic exercise should be more critically evaluated for the early prevention of cardiotoxic complications.…”

Section: Treatmentmentioning

confidence: 99%

Cancer Treatment-Induced Cardiotoxicity: a Cardiac Stem Cell Disease?

Prezioso¹,

Tanzi²,

Galaverna

et al. 2010

CHAMC

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Cardiovascular diseases and cancer represent respectively the first and second cause of death in industrialized countries. These two conditions may become synergistic when cardiovascular complications of anti-cancer therapy are considered. More than 70% of childhood and 50% of adult cancer patients can be cured, however this important success obtained by the biological and medical research is obfuscated by emerging findings of early and late morbidity due to cardiovascular events. Although anthracyclines are effective drugs against cancer a dose-dependent cardiotoxic effects whose mechanism has not been elucidated resulting in failure of therapeutic interventions limit their use. Unexpectedly, tyrosine/kinase inhibitors (TKIs) aimed at molecularly interfering with oncogenic pathways, have been implicated in cardiac side effects. Possible explanations of this phenomenon have been ambiguous, further strengthening the need to deepen our understanding on the mechanism of cardiotoxicity. In addition to a detailed description of anthracyclines and TKIs-related cardiovascular effects, the present review highlights recent observations supporting the hypothesis that the cellular target of anthracyclines and TKIs may include myocardial compartments other than parenchymal cells. The demonstration that the adult mammalian heart possesses a cell turnover regulated by primitive cells suggests that this cell population may be implicated in the onset and development of cardiovascular effects of anti-cancer strategies. The possibility of preventing cardiotoxicity by preservation and/or expansion of the resident stem cell pool responsible for cardiac repair may open new therapeutic options to unravel an unsolved clinical issue.

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“…Compared with age-matched healthy normals, peak exercise capacity is reduced approximately 40-50% in patients with heart failure (Kraus, W., &Keteyian S., 2007) that can isolate them socially and contribute to poorer behavioral adjustment (Miller T., Horgan S., &. Lipshults S., 2005).…”

Section: Resultsmentioning

confidence: 99%

Untitled

2016

JPES

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Abstract. The recommendations of various countries for the treatment of patients with chronic heart failure are analyzed in the article. Because physical training are included in a comprehensive program of rehabilitation for patients with heart failure, it is established the necessity to develop the program of exercise training for children with heart failure in Ukraine that must be included in a comprehensive rehabilitation program. Because physical activity has positive effect not only on functional capacity and physical development of the children but also helps to stabilize and improve mood, better psychosocial functioning, better perception of drug therapy.

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Exercise rehabilitation of pediatric patients with cardiovascular disease

Cited by 28 publications

References 78 publications

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

Long-term Cardiovascular Toxicity in Children, Adolescents, and Young Adults Who Receive Cancer Therapy: Pathophysiology, Course, Monitoring, Management, Prevention, and Research Directions

Cancer Treatment-Induced Cardiotoxicity: a Cardiac Stem Cell Disease?

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