Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model

Ferrarini, Eduarda Gomes; Gonçalves, Elaine Cristina Dalazen; Menegasso, Jaíne Ferrareis; Rabelo, Bruna Daniel; Felipetti, Francielly Andressa; Dutra, Rafael Cypriano

doi:10.1016/j.neuroscience.2021.04.017

Cited by 10 publications

(10 citation statements)

References 50 publications

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“…These results are consistent with previous findings in which animals treated with repeated doses of reserpine showed signs of reflexive pain accompanied by signs of nonreflexive pain (e.g., anxiety or depression) [ 7 , 28 , 75 , 76 , 77 ]. Similar to the present work, pregabalin treatment relieved muscle pain [ 78 ] and ameliorated thermal hyperalgesia and/or mechanical allodynia [ 7 , 76 ] in other animal models subjected to reserpine-induced myalgia.…”

Section: Resultssupporting

confidence: 93%

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

Bagó-Mas

Deulofeu

Vela³

et al. 2022

IJMS

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Sigma-1 receptor (s1R) ligands have been shown to be effective at relieving neuropathic and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia. The objective of this study was to evaluate the effect of a s1R antagonist (BD1063) compared to pregabalin. ICR-CD1 female mice were subjected to either six repeated injections of reserpine, to cause reserpine-induced myalgia (RIM6), or acidified saline intramuscular injections (ASI). In these two models, we evaluated the effect of BD1063 and pregabalin on thermal hypersensitivity, anxiety-like and depression-like behaviors, and on spinal cord gliosis. BD1063 exerted an antinociceptive effect on both reflexive (thermal hyperalgesia) and nonreflexive (anxiety- and depression-like) pain behaviors, and reduced spinal astroglial and microglial reactivity, following repeated treatment for 2 weeks. Interestingly, the effects of BD1063 were long-term, lasting several weeks after treatment discontinuation in both fibromyalgia-like models. Similar results were obtained with pregabalin, but the effects on pain behaviors lasted for a shorter length of time, and pregabalin did not significantly modulate spinal glial reactivity. The inhibitory and long-lasting effect of pharmacological blockade of s1Rs on both sensory and affective dimensions of nociplastic-like pain and spinal cord gliosis in two experimental models of fibromyalgia support the application of this therapeutic strategy to treat fibromyalgia.

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Section: Resultssupporting

confidence: 93%

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

Bagó-Mas

Deulofeu

Vela³

et al. 2022

IJMS

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“…All of this suggests that the symptoms of fibromyalgia could be linked to physical inactivity, with exercise being the basic element of treatment, with low cost and high effectiveness. The effect of exercise could be associated with changes in body composition [31], so Salm et al (2019) [20] analyzed biochemical markers in the patients. The combination of exercise with changes in body temperature attributable to complementary techniques [32,33] could also modify body composition.…”

Section: Discussionmentioning

confidence: 99%

Aquatic Exercise in Physical Therapy Treatment for Fibromyalgia: Systematic Review

Rodríguez-Huguet,

Ayala-Martínez,

Góngora-Rodríguez

et al. 2024

Healthcare

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Fibromyalgia is a chronic condition characterized by musculoskeletal pain. The aim of this study was to synthesize scientific evidence on the effects of aquatic exercise programs on pain and quality of life in individuals with fibromyalgia. This review was carried out using the following databases in January 2024: Cochrane Library, PEDro, PubMed, SCOPUS, and Web of Science. Four clinical trials focusing on aquatic exercise as a treatment for patients with fibromyalgia were selected. These trials were published in English between 2019 and 2024. Pain recorded using the Visual Analog Scale (VAS) and quality of life with the Short Form-36 Health Survey (SF-36) or Fibromyalgia Impact on Quality of Life (FIQ) were the most commonly analyzed variables. This review was carried out according to the PRISMA statement and was registered in PROSPERO (CRD42024510219). The results in terms of pain and quality of life were positive. In conclusion, these findings support the incorporation of aquatic exercise into fibromyalgia physical therapy treatment. However, the benefits could be equivalent to those of other exercise modalities, underscoring the need for individualized adaptation to each patient’s needs.

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“…Recent evidence suggest that voluntary exercise could be sufficient to prevent the full expression of mechanical hypersensitivity and depression-like behaviors in rodents ( Grace et al, 2016 ; Eldomiaty et al, 2017 ; Pagliusi et al, 2020 ; Ferrarini et al, 2021 ) and humans ( Marshall et al, 2017 ; Izquierdo-Alventosa et al, 2020 ). However, we could not differentiate between the contribution of increased exercise and the cognitive challenges through sensory stimulation in our ExEE housing protocol.…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment promotes resilience to neuropathic pain-induced depression and correlates with decreased excitability of the anterior cingulate cortex

Falkowska

Ntamati

Nevian

et al. 2023

Front. Behav. Neurosci.

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Depression is a common comorbidity of chronic pain with many patients being affected. However, efficient pharmacological treatment strategies are still lacking. Therefore, it is desirable to find additional alternative approaches. Environmental enrichment has been suggested as a method to alleviate pain-induced depression. However, the neuronal mechanisms of its beneficial effects are still elusive. The anterior cingulate cortex (ACC) plays a central role in processing pain-related negative affect and chronic pain-induced plasticity in this region correlates with depressive symptoms. We studied the consequences of different durations of environmental enrichment on pain sensitivity and chronic pain-induced depression-like behaviors in a mouse model of neuropathic pain. Furthermore, we correlated the behavioral outcomes to the activity levels of pyramidal neurons in the ACC by analyzing their electrophysiological properties ex vivo. We found that early exposure to an enriched environment alone was not sufficient to cause resilience against pain-induced depression-like symptoms. However, extending the enrichment after the injury prevented the development of depression and reduced mechanical hypersensitivity. On the cellular level, increased neuronal excitability was associated with the depressive phenotype that was reversed by the enrichment. Therefore, neuronal excitability in the ACC was inversely correlated to the extended enrichment-induced resilience to depression. These results suggest that the improvement of environmental factors enhanced the resilience to developing chronic pain-related depression. Additionally, we confirmed the association between increased neuronal excitability in the ACC and depression-like states. Therefore, this non-pharmacological intervention could serve as a potential treatment strategy for comorbid symptoms of chronic pain.

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Exercise Reduces Pain and Deleterious Histological Effects in Fibromyalgia-like Model

Cited by 10 publications

References 50 publications

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models

Aquatic Exercise in Physical Therapy Treatment for Fibromyalgia: Systematic Review

Environmental enrichment promotes resilience to neuropathic pain-induced depression and correlates with decreased excitability of the anterior cingulate cortex

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