Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p

Lou, Jing; Wu, Jie; Feng, Mengya; Dang, Xue; Wu, Guiling; Yang, Hongyan; Wang, Yan; Li, Jia; Zhao, Yong; Shi, Changhong; Liu, Jiankang; Zhao, Lin; Zhang, Xing; Gao, Feng

doi:10.1016/j.jshs.2021.09.009

Cited by 34 publications

(32 citation statements)

References 50 publications

(62 reference statements)

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“…A distinguished incidence of intussusceptive angiogenesis was also observed in the COVID-19 patients (53). In agreement with this observation, miR-122-5p promotes angiogenesis and is a strong pro-angiogenic factor that actuates vascular endothelial growth factor signaling (54). MiR-122-5p and miR-98-5p target CHST3 which is involved in cell adhesion through synthesizing chondroitin 6-sulfate (55).…”

Section: Discussionsupporting

confidence: 64%

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

Ghobadi

Emamzadeh²,

Teymoori‐Rad³

et al. 2022

Front. Immunol.

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Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) is the causative virus of the pandemic coronavirus disease 2019 (COVID-19). Evaluating the immunological factors and other implicated processes underlying the progression of COVID-19 is essential for the recognition and then the design of efficacious therapies. Therefore, we analyzed RNAseq data obtained from PBMCs of the COVID-19 patients to explore coding and non-coding RNA diagnostic immunological panels. For this purpose, we integrated multiple RNAseq data and analyzed them overall as well as by considering the state of disease including severe and non-severe conditions. Afterward, we utilized a co-expressed-based machine learning procedure comprising weighted-gene co-expression analysis and differential expression gene as filter phase and recursive feature elimination-support vector machine as wrapper phase. This procedure led to the identification of two modules containing 5 and 84 genes which are mostly involved in cell dysregulation and innate immune suppression, respectively. Moreover, the role of vitamin D in regulating some classifiers was highlighted. Further analysis disclosed the role of discriminant miRNAs including miR-197-3p, miR-150-5p, miR-340-5p, miR-122-5p, miR-1307-3p, miR-34a-5p, miR-98-5p and their target genes comprising GAN, VWC2, TNFRSF6B, and CHST3 in the metabolic pathways. These classifiers differentiate the final fate of infection toward severe or non-severe COVID-19. The identified classifier genes and miRNAs may help in the proper design of therapeutic procedures considering their involvement in the immune and metabolic pathways.

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Section: Discussionsupporting

confidence: 64%

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

Ghobadi

Emamzadeh²,

Teymoori‐Rad³

et al. 2022

Front. Immunol.

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“… 100 A recent study reports that exercise-associated microRNA-122-5p (miR-122-5p) is capable of promoting wound healing via increasing capillary density in the perilesional skin tissues of mice. 101 However, the molecular and cellular mechanisms through which exercise stimulates healing require further investigation.…”

Section: Exercise Benefits the Maintenance Of Local Homeostasismentioning

confidence: 99%

Exercise sustains the hallmarks of health

Qiu

Fernández‐García

Lehmann

et al. 2023

Journal of Sport and Health Science

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“… 345 , 346 More recently, liver-derived extracellular vesicle miR-122-5p after treadmill training was reported to promote angiogenesis through shifting substrate preference to fatty acids in endothelial cells by targeting 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT1), increasing capillary density in the quadriceps, and accelerating wound healing in mice. 347 In addition, treadmill exercise training has been also reported to influence the miRNA profiles of bone tissue, such as miR-190a-5p, miR-203-5p, miR-27a-5p, and miR-5118. 348 Importantly, miR-27a-5p is confirmed as a member of miR-23a cluster.…”

Section: Molecular Mechanisms Of Tissue Regeneration Induced By Exercisementioning

confidence: 99%

Molecular mechanisms of exercise contributing to tissue regeneration

Chen

Zhou

et al. 2022

Sig Transduct Target Ther

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Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle. Recent rapid advances in molecular biotechnology have demonstrated that both endurance and resistance exercise training, two traditional types of exercise, trigger a series of physiological responses, unraveling the mechanisms of exercise regulating on the human body. Therefore, exercise has been expected as a candidate approach of alleviating a wide range of diseases, such as metabolic diseases, neurodegenerative disorders, tumors, and cardiovascular diseases. In particular, the capacity of exercise to promote tissue regeneration has attracted the attention of many researchers in recent decades. Since most adult human organs have a weak regenerative capacity, it is currently a key challenge in regenerative medicine to improve the efficiency of tissue regeneration. As research progresses, exercise-induced tissue regeneration seems to provide a novel approach for fighting against injury or senescence, establishing strong theoretical basis for more and more “exercise mimetics.” These drugs are acting as the pharmaceutical alternatives of those individuals who cannot experience the benefits of exercise. Here, we comprehensively provide a description of the benefits of exercise on tissue regeneration in diverse organs, mainly focusing on musculoskeletal system, cardiovascular system, and nervous system. We also discuss the underlying molecular mechanisms associated with the regenerative effects of exercise and emerging therapeutic exercise mimetics for regeneration, as well as the associated opportunities and challenges. We aim to describe an integrated perspective on the current advances of distinct physiological mechanisms associated with exercise-induced tissue regeneration on various organs and facilitate the development of drugs that mimics the benefits of exercise.

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Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p

Cited by 34 publications

References 50 publications

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

Exploration of blood−derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure

Exercise sustains the hallmarks of health

Molecular mechanisms of exercise contributing to tissue regeneration

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