Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins

Sun, Gwo‐Ching; Lee, Yi‐Ju; Lee, Yi‐Ching; Yu, Hsien-Fu; Wang, Dean-Chuan

doi:10.1016/j.bbr.2021.113444

Cited by 16 publications

(9 citation statements)

References 81 publications

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“…Considering the biased estimation and in ated false caused by the collinearity of phthalates in single pollutant analysis (Pitard and Viel, 1997), the nding that MEHP was associated with cognitive impairment in elders should be interpreted with caution. However, as a typical representative of phthalates, DEHP was reported to disrupt spatial learning and memory abilities, impair blood-brain barriers and decrease synaptic proteins in experimental animals (Ahmadpour et al, 2021;Sun et al, 2021). One possible explanation for this observation is that the concentrations of DEHP used in those experimental animals were much higher than the environmental DEHP exposure of humans in this study.…”

Section: Discussionmentioning

confidence: 64%

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Wang

Dong

et al. 2023

Environ Sci Pollut Res

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Phthalates are a group of neurotoxicants with cognitive-disrupting potentials. Given the structural diversity of phthalates, the corresponding neurotoxicity is dramatically altered. To identify the potential contributions of different phthalates on the process of cognitive impairment, data of 836 elders from the NHANES 2011-2014 cycles were used. Survey-weighted logistic regression and principal component analysis-weighted quantile sum regression (PCA-WQSR) models were applied to estimate the independent and combined associations of 11 urinary phthalate metabolites with cognitive de cit [assessed by 4 tests: Immediate Recall (IR), Delayed Recall (DR), Animal Fluency (AF), and Digit Symbol Substitution test (DSST] and to identify the potential phthalate with high weight. Laboratory mice were further used to examine the effect of phthalates on cognitive function and to explore the potential mechanisms. In logistic regression models, MBzP was the only metabolite positively correlated with four tests, with ORs of 2.53 [quartile 3 (Q3)], 2.26 (Q3), 2.89 (Q4) and 2.45 (Q2), 2.82 (Q4) for IR, DR, AF and DSST respectively. In PCA-WQSR co-exposure models, low-molecular-weight (LMW) phthalates were the only PC positively linked to DSST de cit (OR: 1.93), which was further validated in WQSR analysis (WQS OR 7 − phthalates : 1.56 and WQS OR 8 − phthalates : 1.55); consistent with the results of logistic regression, MBzP was the dominant phthalate. In mice, butyl benzyl phthalate (BBP), the parent phthalate of MBzP, dose-dependently reduced cognitive function and disrupted hippocampal neurons. Additionally, the hippocampal transcriptome analysis identi ed 431 differential expression genes, among which most were involved in inhibiting the neuroactive ligand-receptor interaction pathway and activating the cytokine-cytokine receptor interaction pathway. Our study indicates the critical role of BBP in the association of phthalates and cognitive de cits among elderly individuals, which might be speculated that BBP could disrupt hippocampal neurons, activate neuroin ammation and inhibit neuroactive receptors. Our ndings provide new insight into the cognitive-disrupting potential of BBP.

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Section: Discussionmentioning

confidence: 64%

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Wang

Dong

et al. 2023

Environ Sci Pollut Res

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“…Accordingly, the DDO is also considered an attractive therapeutic target [40]. D-Aspartate as well as D-Serine have been revealed to be involved in learning and/or memory [5,41]. expressed in the brain [40].…”

Section: D-amino Acids In Brainmentioning

confidence: 99%

D-Amino Acids as a Biomarker in Schizophrenia

et al. 2022

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D-amino acids may play key roles for specific physiological functions in different organs including the brain. Importantly, D-amino acids have been detected in several neurological disorders such as schizophrenia, amyotrophic lateral sclerosis, and age-related disorders, reflecting the disease conditions. Relationships between D-amino acids and neurophysiology may involve the significant contribution of D-Serine or D-Aspartate to the synaptic function, including neurotransmission and synaptic plasticity. Gut-microbiota could play important roles in the brain-function, since bacteria in the gut provide a significant contribution to the host pool of D-amino acids. In addition, the alteration of the composition of the gut microbiota might lead to schizophrenia. Furthermore, D-amino acids are known as a physiologically active substance, constituting useful biomarkers of several brain disorders including schizophrenia. In this review, we wish to provide an outline of the roles of D-amino acids in brain health and neuropsychiatric disorders with a focus on schizophrenia, which may shed light on some of the superior diagnoses and/or treatments of schizophrenia.

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“…In the brain, this angiogenesis in regions especially hippocampus which can lead to neurogenesis and brain plasticity along with its effect on adiponectin level, Irisin, lactate, beta-hydroxy-butyric acid. 18 Which physical activity type, is the most effective?…”

Section: Introductionmentioning

confidence: 99%

Underlying mechanisms for physical activity-induced brain plasticity

Moiniafshari¹,

kalantari²,

Nezhad³

2023

AOWMC

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Physical activity is an important component in daily life which become more important when comes to health-related complications. Physical activity regardless the type and intensity, can bring beneficial effect for general health and can improve skills in several aspects including learning tasks and response to stimuli along with other health benefits. By recruiting regular physical activity and exercise, which happened for athletes, some structural and functional changes may occur in some regions of brain including increase in network connection, increase the speed of message transformation, increase in gray matter, synaptic plasticity and brain plasticity. There are several suggested mechanisms for physical activity-induced brain plasticity including increase in gene expression, BDNF, IGF-1, VEGF and activation of cellular cascade. Although the beneficial effects of physical activity on brain flexibility is well known which is reviled in athletes, the most effective type of activity which can affect brain flexibility the most, is not clear yet.

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Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins

Cited by 16 publications

References 81 publications

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

D-Amino Acids as a Biomarker in Schizophrenia

Underlying mechanisms for physical activity-induced brain plasticity

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