Exercise Prescription: Pioneering the “Third Pole” for Clinical Health Management

Luo, Zhiwen; Zhang, Ting; Chen, Shiyi

doi:10.34133/research.0284

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Following a comprehensive study of the biological mechanisms by which exercise improves KOA, the focus has now shifted towards the clinical efficacy of exercise therapy in treating KOA. Physicians specializing in sports medicine and qualified exercise rehabilitation therapists are capable of formulating such exercise prescriptions, ensuring that recipients, including elderly individuals with KOA, receive the most appropriate exercise guidance ( 74 ). This section specifically analyzes the impact of exercise training on KOA patients, highlighting key aspects such as physical function, quality of life, and pain alleviation, which are crucial for patients’ daily living and overall health.…”

Section: Resultsmentioning

confidence: 99%

“…While some studies indicate higher adherence to traditional Chinese exercises due to its holistic approach and community support, others suggest that the simplicity and flexibility of general exercises foster greater adherence. Strategies to increase adherence could include personalized exercise programs, regular follow-ups, and integrating exercises into daily routines ( 74 ). These contents have been summarized in Table 2 .…”

Section: Comparative Analysis Of General Exercise Training and Tradit...mentioning

confidence: 99%

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What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Du,

Fan,

Kong

2024

Front. Med.

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BackgroundKnee osteoarthritis (KOA) is a disease that significantly affects the quality of life of patients, with a complex pathophysiology that includes degeneration of cartilage and subchondral bone, synovitis, and associations with mechanical load, inflammation, metabolic factors, hormonal changes, and aging.ObjectiveThis article aims to comprehensively review the biological mechanisms and clinical effects of general exercise training and traditional Chinese exercises (such as Tai Chi and Qigong) on the treatment of KOA, providing references for the development of clinical exercise prescriptions.MethodsA systematic search of databases including PubMed, Web of Science, Google Scholar, and China National Knowledge Infrastructure (CNKI) was conducted, reviewing studies including randomized controlled trials (RCTs), observational studies, systematic reviews, and meta-analyses. Keywords included “knee osteoarthritis,” “exercise therapy,” “physical activity,” and “traditional Chinese exercise.”Results and conclusionGeneral exercise training positively affects KOA by mechanisms such as promoting blood circulation, improving the metabolism of inflammatory factors, enhancing the expression of anti-inflammatory cytokines, and reducing cartilage cell aging. Traditional Chinese exercises, like Tai Chi and Qigong, benefit the improvement of KOA symptoms and tissue repair by regulating immune function and alleviating joint inflammation. Clinical studies have shown that both types of exercise can improve physical function, quality of life, and pain relief in patients with KOA. Both general exercise training and traditional Chinese exercises are non-pharmacological treatment options for KOA that can effectively improve patients’ physiological function and quality of life. Future research should further explore the long-term effects and biological mechanisms of these exercise interventions and develop personalized exercise programs based on the specific needs of patients.

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Section: Resultsmentioning

confidence: 99%

Section: Comparative Analysis Of General Exercise Training and Tradit...mentioning

confidence: 99%

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Du,

Fan,

Kong

2024

Front. Med.

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Translational studies of exosomes in sports medicine – a mini-review

Huang,

Chen,

Feng

et al. 2024

Front. Immunol.

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This review in sports medicine focuses on the critical role of exosomes in managing chronic conditions and enhancing athletic performance. Exosomes, small vesicles produced by various cells, are essential for cellular communication and transporting molecules like proteins and nucleic acids. Originating from the endoplasmic reticulum, they play a vital role in modulating inflammation and tissue repair. Their significance in sports medicine is increasingly recognized, particularly in healing athletic injuries, improving articular cartilage lesions, and osteoarthritic conditions by modulating cellular behavior and aiding tissue regeneration. Investigations also highlight their potential in boosting athletic performance, especially through myocytes-derived exosomes that may enhance adaptability to physical training. Emphasizing a multidisciplinary approach, this review underlines the need to thoroughly understand exosome biology, including their pathways and classifications, to fully exploit their therapeutic potential. It outlines future directions in sports medicine, focusing on personalized treatments, clinical evaluations, and embracing technological advancements. This research represents a frontier in using exosomes to improve athletes’ health and performance capabilities.

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Exercise-downregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer

Luo,

Zhu,

et al. 2024

Front. Immunol.

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BackgroundBreast cancer ranks as one of the most prevalent malignancies among women globally, with increasing incidence rates. Physical activity, particularly exercise, has emerged as a potentially significant modifier of cancer prognosis, influencing tumor biology and patient outcomes.MethodsUsing a murine breast cancer model, we established a control and an exercise group, where the latter was subjected to 21 days of voluntary running. RNA Sequencing, bioinformatics analysis, pan-cancer analysis, and cell experiments were performed to validate the underlying mechanisms.ResultsWe observed that exercise significantly reduced tumor size and weight, without notable changes in body weight, suggesting that physical activity can modulate tumor dynamics. mRNA sequencing post-exercise revealed substantial downregulation of CD300E in the exercise group, accompanied by alterations in critical pathways such as MicroRNAs in cancers and the Calcium signaling pathway. Expanding our analysis to a broader cancer spectrum, CD300E demonstrated significant expression variability across multiple cancer types, with pronounced upregulation in myeloma, ovarian, lung, and colorectal cancers. This upregulation was correlated with poorer prognostic outcomes, emphasizing CD300E’s potential role as a prognostic marker and therapeutic target. Moreover, CD300E expression was associated with cancer cell proliferation and apoptosis.ConclusionThe study highlights the dual role of exercise in modulating gene expression relevant to tumor growth and the potential of CD300E as a target in cancer therapeutics. Further research is encouraged to explore the mechanisms by which exercise and CD300E influence cancer progression and to develop targeted strategies that could enhance patient outcomes in clinical settings.

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Exercise Prescription: Pioneering the “Third Pole” for Clinical Health Management

Cited by 7 publications

References 15 publications

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

What improvements do general exercise training and traditional Chinese exercises have on knee osteoarthritis? A narrative review based on biological mechanisms and clinical efficacy

Translational studies of exosomes in sports medicine – a mini-review

Exercise-downregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer

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