Exercise mode influences post‐exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex‐dependent manner: A randomized control trial

Abstract

Type 2 diabetes (T2D) risk is lower in females than males. It has been reported that females have greater pancreatic 𝛽cell function than males, which may at least in part contribute to the T2D risk in females. 𝛽cell function is influenced by exercise training; however, previous trials comparing 𝛽cell function between the sexes have not included participants matched for training status. Furthermore, the acute effects of different modes of exercise on 𝛽cell function, and whether sex inherently influences these effects, are largely unexamined. Males and females (12/sex) completed a 120-min oral glucose tolerance test (OGTT) at rest (CON) and following acute bouts of high-intensity interval exercise (HIIE), mod-How to cite this article: Beaudry, K. M., Surdi, J. C., Mari, A., & Devries, M. C. (2022). Exercise mode influences post-exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex-dependent manner: A randomized control trial. Physiological Reports,

Effects of Konjac Glucomannan on indicators of metabolic syndrome in adults with schizophrenia

“…The reduction of 10 mmHg in blood pressure levels resistance in this study may therefore be clinically meaningful, and partly attributable to improvements in central obesity and adipocyte insulin resistance (Zhu, 2018;Wang et al, 2012). After four weeks, the small but statistically significant decrease in GDP (p,0.004) was greater than previously reported (Beaudry et al, 2022;Bullard et al, 2019). Following a 4-week KGM training intervention study.…”

The SmartRX trial: Acute effectS of manipulating stRength eXercise volume on insulin sensitivity in overweight/obese adults: a protocol for a randomized controlled, crossover, clinical trial

“…In case the experimental sessions are scheduled 21 to 28 days apart, participants will be required to perform a familiarization session 2 weeks after the preceding (and 1 to 2 weeks before the following) experimental session to avoid defamiliarization. To avoid the variation in insulin sensitivity across the menstrual cycle [35][36][37][38][39][40][41], in case premenopausal women are included in the sample, they will be assessed in the follicular phase (days 1-14) [16,27,[42][43][44] of their menstrual cycle. Two of the sessions will be performed with strength exercises: high-volume session: 3 sets per exercise; low-volume session: 1 set per exercise; and a control session: no exercise.…”

“…Also, OGTT is considered reliable and consistent for estimating insulin sensitivity over consecutive days [87]. Last, but not the least, the majority of studies that assessed the acute effects of a strength exercise session on insulin sensitivity employed OGTT as the assessment tool [12,16,27,42,[88][89][90][91][92][93][94][95].…”

Type 1 Diabetes and the Menstrual Cycle: Where/How Does Exercise Fit in?

“…Following an acute bout of moderate-intensity exercise, for example, insulin clearance is higher in females than males. Interestingly, in females insulin clearance and glucose sensitivity are greater following high-intensity interval exercise compared to moderate-intensity continuous exercise [96]. As for T1D, however, more research is required to examine these findings, especially with regard to the menstrual cycle and the effects of different cycle phases.…”

“…The combination of aerobic and resistance exercise training has also been suggested to be more effective than either mode alone[94].In addition to insulin sensitivity, exercise can affect insulin clearance and glucose sensitivity. In particular, both exercise mode and sex affect glucose sensitivity and insulin clearance in those without diabetes[96]. Following an acute bout of moderate-intensity exercise, for example, insulin clearance is higher in females than males.…”