Exercise Is Medicine…and the Dose Matters

Langan, Sean P.; Grosicki, Gregory J.

doi:10.3389/fphys.2021.660818

Cited by 11 publications

(16 citation statements)

References 43 publications

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“…It is well documented that HIIT provides a robust stimulus for central cardiovascular adaptations and metabolic stress [28], while MICT mainly triggers peripheral adaptations contributing to muscular oxygen extraction and metabolic efficiency [29][30][31]. HIIT is known to elicit higher enjoyment than MICT, as reported by original research [32] and meta-analysis [33], making the interval training model a practical and enjoyable exercise mode for the general population.…”

Section: Interval Trainingmentioning

confidence: 99%

Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective

Atakan

Koşar

et al. 2021

IJERPH

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Engaging in regular exercise results in a range of physiological adaptations offering benefits for exercise capacity and health, independent of age, gender or the presence of chronic diseases. Accumulating evidence shows that lack of time is a major impediment to exercise, causing physical inactivity worldwide. This issue has resulted in momentum for interval training models known to elicit higher enjoyment and induce adaptations similar to or greater than moderate-intensity continuous training, despite a lower total exercise volume. Although there is no universal definition, high-intensity interval exercise is characterized by repeated short bursts of intense activity, performed with a “near maximal” or “all-out” effort corresponding to ≥90% of maximal oxygen uptake or >75% of maximal power, with periods of rest or low-intensity exercise. Research has indicated that high-intensity interval training induces numerous physiological adaptations that improve exercise capacity (maximal oxygen uptake, aerobic endurance, anaerobic capacity etc.) and metabolic health in both clinical and healthy (athletes, active and inactive individuals without any apparent disease or disorder) populations. In this paper, a brief history of high-intensity interval training is presented, based on the novel findings of some selected studies on exercise capacity and health, starting from the early 1920s to date. Further, an overview of the mechanisms underlying the physiological adaptations in response to high-intensity interval training is provided.

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Section: Interval Trainingmentioning

confidence: 99%

Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective

Atakan

Koşar

et al. 2021

IJERPH

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“…Finally, it is not as though there are no data concerning scientific wellness and thus proven long-term strategies for generally improving and/or maintaining health and wellness. These can be as simple (and financially relatively reasonable) as a balanced diet emphasizing moderation, regular reasonably vigorous exercise, continuous learning, a personally satisfying level of interpersonal/community interactions, and an effective means of de-stressing [50,[61][62][63][64]. These are not "sexy" and do not involve the latest technological wonder devices or "brought-back-from-the-end-of-the-world" botanical compound, but they are tried and tested.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, there are even data indicating that members of the general population become somewhat complacent about their health when they receive what are interpreted to be "negative" genetic reports, believing that genes are fate and that they need not bother with their health as "there is nothing to be done anyway". Such a broad lack of appropriate education on these matters, prior to receiving testing and its results, is, at best, negligent, as genes are not fate; research continuously establishes that, even in the case of many monogenic disorders, lifestyle can have the most substantial impact on phenotype and disease progression [47][48][49][50][51]. The majority of scientific wellness ventures are thus admirably geared towards preventing diseases and promoting health by changing lifestyles.…”

Section: Lessons Learnedmentioning

confidence: 99%

Profit versus Quality: The Enigma of Scientific Wellness

Carbonara

MacNeil

O’Leary

et al. 2022

JPM

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The “best of both worlds” is not often the case when it comes to implementing new health models, particularly in community settings. It is often a struggle between choosing or balancing between two components: depth of research or financial profit. This has become even more apparent with the recent shift to move away from a traditionally reactive model of medicine toward a predictive/preventative one. This has given rise to many new concepts and approaches with a variety of often overlapping aims. The purpose of this perspective is to highlight the pros and cons of the numerous ventures already implementing new concepts, to varying degrees, in community settings of quite differing scales—some successful and some falling short. Scientific wellness is a complex, multifaceted concept that requires integrated experimental/analytical designs that demand both high-quality research/healthcare and significant funding. We currently see the more likely long-term success of those ventures in which any profit is largely reinvested into research efforts and health/healthspan is the primary focus.

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“…This assumption is supported in humans by the findings of a study 25 , which observed no improvements in time to exhaustion during cycling at 90% of maximal oxygen uptake using capsaicin (1.2 mg) 45 min before exercise. Therefore, because higher doses of capsaicin ingestion are not well tolerated and may elicit aside effects 26 , the use of 12 mg of capsaiate supplementation seems to be safe and also improve muscle performance and fatigability.…”

Section: Discussionmentioning

confidence: 99%

Effects of Capsiate Supplementation on Maximal Voluntary Contraction in Healthy Men

et al. 2021

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This study aimed to investigate the effects of acute capsaicin analog (Capsiate - CAP) supplementation on maximal voluntary isometric contraction (MVIC) performance in healthy young men. Thirteen subjects (25.2±3.2 yrs) participated in the present study. In two different days separated by one week, the subjects ingested capsiate (12 mg) or placebo (starch: 12 mg) 45 minutes before a MVIC test. The MVIC test consisted of five 10-second knee extension maximal isometric contractions with 45 seconds of recovery between efforts. The peak force, mean force, minimum force, fatigue index, and area under the curve of each contraction were calculated. Main condition effect was found, with higher values of peak force (+4.83%, F=6.867, p=0.02), fatigue index (+8.96%, F=5.228, p=0.041), and area under the curve (+4.19%, F=4.774, p=0.04) for CAP compared to placebo, however, no interaction effect was found for any variable (F=0.090 to 1.356, p≥0.276). In summary, healthy young men produced higher maximal isometric force and delayed fatigue in the CAP condition compared to placebo condition (condition effect) but without significant difference between each effort.

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Exercise Is Medicine…and the Dose Matters

Cited by 11 publications

References 43 publications

Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective

Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective

Profit versus Quality: The Enigma of Scientific Wellness

Effects of Capsiate Supplementation on Maximal Voluntary Contraction in Healthy Men

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